标签归档：peptide

EGFRvIII peptide (PEPvIII)

发表于由
回复

EGFRvIII peptide (PEPvIII);

EGFRvIII peptide (PEPvIII) 是一种肿瘤特异性突变，广泛表达于多形性胶质母细胞瘤 (GBM) 和其他肿瘤中，其表达增强了肿瘤发生率。EGFRvIII peptide (PEPvIII) 是抗肿瘤免疫的一个真正的特异性靶点。

EGFRvIII peptide (PEPvIII)amp;;

EGFRvIII peptide (PEPvIII) Chemical Structure

CAS No. : 129112-17-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

EGFRvIII peptide (PEPvIII) is a tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms and its expression enhances tumorigenicity. EGFRvIII peptide represents a truly tumor-specific target for antitumor immunotherapy[1].

分子量

1634.81

Formula

C70H111N19O24S
CAS 号

129112-17-0
Sequence Shortening

LEEKKGNYVVTDHC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Schmittling RJ, et al. Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines. J Immunol Methods. 2008 Nov 30;339(1):74-81.

Competence-Stimulating Peptide-2 (CSP-2)

发表于由
回复

Competence-Stimulating Peptide-2 (CSP-2);

Competence-Stimulating Peptide-2 (CSP-2) 是肺炎链球菌产生的群体感应信号肽。ComD2 是 Competence-Stimulating Peptide-2 (CSP-2) 的兼容受体，EC50 值为 50.7 nM。

Competence-Stimulating Peptide-2 (CSP-2)amp;;

Competence-Stimulating Peptide-2 (CSP-2) Chemical Structure

CAS No. : 1174553-84-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Competence-Stimulating Peptide-2 (CSP-2) is a quorum sensing signal peptide produced by Streptococcus pneumoniae. ComD2 is a compatible receptor of Competence-Stimulating Peptide-2 (CSP-2) with an EC50 value of 50.7 nM[1].

分子量

2178.69

Formula

C101H172N28O23S
CAS 号

1174553-84-4
Sequence Shortening

EMRISRIILDFLFLRKK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Yifang Yang, et al. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumonia. Biochemistry. 2018 Sep 11;57(36):5359-5369.

MARCKS Peptide(151-175), Phosphorylated

发表于由
回复

MARCKS Peptide(151-175), Phosphorylated;

MARCKS Peptide(151-175), Phosphorylated 是一种由豆蔻酰化富丙氨酸 C 激酶底物蛋白 (MARCKS) 基本效应域片段组成的磷酸化多肽，MARCKS Peptide (151-175) 的磷酸化逆转了它对磷脂酶 C (PLC) 催化磷脂酰肌醇 -4,5- 二磷酸 (PIP2) 水解的抑制作用。

MARCKS Peptide(151-175), Phosphorylatedamp;;

MARCKS Peptide(151-175), Phosphorylated Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

MARCKS Peptide(151-175), Phosphorylated is a phosphorylated peptide corresponding to the basic effector domain of myristoylated alanine-rich protein kinase C substrate protein (MARCKS). Phosphorylation of MARCKS Peptide (151-175) reverses its inhibition of phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2)[1].

分子量

3320.80

Formula

C147H246N41O40P3
Sequence

Lys-Lys-Lys-Lys-Lys-Arg-Phe-{pSer}-Phe-Lys-Lys-{pSer}-Phe-Lys-Leu-Ser-Gly-Phe-{pSer}-Phe-Lys-Lys-Asn-Lys-Lys
Sequence Shortening

KKKKKRF-{pSer}-FKK-{pSer}-FKLSGF-{pSer}-FKKNKK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Glaser M, et al. Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains..J Biol Chem. 1996 Oct 18;271(42):26187-93.

OVA G4 peptide

发表于由
回复

OVA G4 peptide;

OVA G4 peptide 是激动剂卵白蛋白肽 SIINFEKL (OVA) (257-264) 的变体。SIINFEKL 通常用于刺激卵白蛋白特异性T细胞，并测试新的疫苗助剂是否能形成稳定的水凝胶。

OVA G4 peptideamp;;

OVA G4 peptide Chemical Structure

CAS No. : 148274-82-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

OVA G4 peptide 的其他形式现货产品:

OVA G4 peptide TFA

生物活性

OVA G4 peptide is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel[1][2].

分子量

906.08

Formula

C43H71N9O12
CAS 号

148274-82-2
Sequence

Ser-Ile-Ile-Gly-Phe-Glu-Lys-Leu
Sequence Shortening

SIIGFEKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. François P, et al. Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E888-97.

    [2]. Kamalov M,et al. Ovalbumin Epitope SIINFEKL Self-Assembles into a Supramolecular Hydrogel. Sci Rep. 2019 Feb 25;9(1):2696.

OVA-E1 peptide TFA

发表于由

OVA-E1 peptide TFA;

OVA-E1 peptide TFA 是SIINFEKL [OVA (257-264)拮抗突变体。OVA-E1 peptide在突变型和野生型胸腺细胞中激活 p38 和 JNK 级联。

OVA-E1 peptide TFAamp;;

OVA-E1 peptide TFA Chemical Structure

CAS No. : 1262750-80-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes[1].

分子量

1119.19

Formula

C49H77F3N10O16
CAS 号

1262750-80-0
Sequence

Glu-Ile-Ile-Asn-Phe-Glu-Lys-Leu
Sequence Shortening

EIINFEKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Leandro J Carreño, et al. The Half-Life of the T-cell receptor/peptide-major Histocompatibility Complex Interaction Can Modulate T-cell Activation in Response to Bacterial Challenge. Immunology. 2007 Jun;121(2):227-37.

Thioredoxin reductase peptide

发表于由

Thioredoxin reductase peptide;

Thioredoxin reductase peptide 是硫氧还蛋白还原酶的 53–67 残基对应的多肽，用于硫氧还蛋白还原酶研究。硫氧还蛋白还原酶作为含二硫化物蛋白质的还原剂，在细胞抗氧化防御中起着重要作用。

Thioredoxin reductase peptideamp;;

Thioredoxin reductase peptide Chemical Structure

CAS No. : 950890-23-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Thioredoxin reductase peptide 的其他形式现货产品:

Thioredoxin reductase peptide TFA

生物活性

Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research. Thioredoxin reductase acts as a reductant of disulfide-containing proteins and plays crucial role in cellular antioxidant defense[1][2].

分子量

1503.79

Formula

C66H106N18O18S2
CAS 号

950890-23-0
Sequence

Trp-Gly-Leu-Gly-Gly-Thr-Cys-Val-Asn-Val-Gly-Cys-Ile-Pro-Lys
Sequence Shortening

WGLGGTCVNVGCIPK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jan YH, et al. Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine(methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling. Chem Res Toxicol. 2014 Jan 21;27(1):61-75.

    [2]. Valette O, et al. Biochemical Function, Molecular Structure and Evolution of an Atypical Thioredoxin Reductase from Desulfovibrio vulgaris. Front Microbiol. 2017 Sep 29;8:1855.

RAGE antagonist peptide

发表于由

RAGE antagonist peptide;

RAGE antagonist peptide 是一种晚期糖基化终产物 (RAGE) 拮抗剂。RAGE antagonist peptide (RAP) 可阻断 RAGE 和几个重要配体 HMGB-1、S100P、S100A4 的结合。RAGE antagonist peptide (RAP) 具有抗肿瘤和抗炎活性。

RAGE antagonist peptideamp;;

RAGE antagonist peptide Chemical Structure

CAS No. : 1092460-91-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

RAGE antagonist peptide 的其他形式现货产品:

RAGE antagonist peptide TFA

生物活性

RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].

体外研究
(In Vitro)

RAGE antagonist peptide (RAP) reduces the ability of the ligands to stimulate RAGE activation of NFκB in cancer cells in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

RAGE antagonist peptide (RAP, 100 µg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo[1].
RAGE antagonist peptide (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth[1].
In mice bearing asthma, RAGE antagonist peptide (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide also reduces total, cytoplasmic and nuclear levels of β-catenin, enhanced β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cancer cells expressing the NFκB-luc reporter implanted into immune-deficient mice[1].
Dosage: 100 µg.
Administration: Intratumoral delivery (or intraperitoneally).
Result: Systemic administration caused a substantial reduction (p<0.05) in the NFκB signal 5 h after injection.

分子量

1272.56

Formula

C57H101N13O17S
CAS 号

1092460-91-7
Sequence Shortening

Ac-ELKVLMEKEL-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64.

    [2]. Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13.

Thymus peptide C

发表于由

Thymus peptide C; 纯度: ge;98.0%

Thymus peptide C 是一种激素药物，来源于牛犊胸腺，它可以替代胸腺的生理功能。

Thymus peptide Camp;;

Thymus peptide C Chemical Structure

CAS No. : 316791-23-8

规格 价格 是否有货 数量
5 mg ￥3500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Thymus peptide C 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Thymus peptide C is a hormonal drug derived from the thymus glands of young calves, which works as a substitute for the physiological functions of the thymus.

体外研究
(In Vitro)

Thymus Peptide C antagonizes the adrenocortical hormones’ effect on the lymphatic system. Thymus Peptide C works as a substitute for the physiological functions of the thymus. With T-cell deficiency, Thymus Peptide C recruits immature system cells in the bone marrow and stimulates their maturation to the fully active T-cell phase in the lymphatic system. Thymus Peptide C increases granulopoiesis and erythropoiesis by acting on the bone marrow. The preparation can be used for all diseases with primary and secondary immune system disturbances involving T-cells which are thymus dependent and for a wide range of symptoms such as chronic viral, bacterial and fungal infections; allergic and auto-immune reactions; and certain lymphoproliferative syndromes.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号

316791-23-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 25 mg/mL (Need ultrasonic and warming)

HA Peptide HA肽 品牌：FUJIFILM Wako

发表于由

HA Peptide

HA肽

品牌：FUJIFILM Wako
CAS No.：92000-76-5
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

084-09163

 for Genetic Research 25 mg –

HA Peptide HA肽 品牌：FUJIFILM Wako

 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

DAPK Substrate Peptide

发表于由

DAPK Substrate Peptide;

DAPK Substrate Peptide 是一种合成的死亡相关蛋白激酶 (DAPK) 的肽底物， Km 为 9 μM。

DAPK Substrate Peptideamp;;

DAPK Substrate Peptide Chemical Structure

CAS No. : 386769-53-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

DAPK Substrate Peptide 的其他形式现货产品:

DAPK Substrate Peptide TFA

生物活性

DAPK Substrate Peptide is a synthetic peptide substrate for death associated protein kinase (DAPK), with a Km of 9 μM[1].

分子量

1578.82

Formula

FK2NPSVY
CAS 号

386769-53-5
Sequence

Lys-Lys-Arg-Pro-Gln-Arg-Arg-Tyr-Ser-Asn-Val-Phe
Sequence Shortening

KKRPQRRYSNVF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Velentza AV. A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates. J Biol Chem. 2001;276(42):38956-38965.