T-peptide

T-peptide;

T-peptide 是一种 Tuftsin 类似物,可用于研究人类免疫缺陷病毒 (HIV) 感染。T-peptide 可防止细胞免疫抑制并提高败血症小鼠的存活率。T-peptide 还可以抑制手术切除后残留肿瘤细胞的生长。

T-peptideamp;;

T-peptide Chemical Structure

CAS No. : 2022956-62-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

T-peptide, a Tuftsin analog, can be used for the research of human immunodeficiency virus (HIV) infection. T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. T-peptide also can inhibit the growth of residual tumor cells after surgical resection[1][2].

分子量

2195.66

Formula

C2H5IKNOV2Y

CAS 号

2022956-62-1

Sequence Shortening

Ac-VQIVYKRRRRRRRRR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Simpson DM, et, al. Peptide T in the treatment of painful distal neuropathy associated with AIDS: results of a placebo-controlled trial. The Peptide T Neuropathy Study Group. Neurology. 1996 Nov;47(5):1254-9.

    [2]. Gao YL, et, al. Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Sci Rep. 2015 Nov 18;5:16725.

Peptide YY (PYY) (3-36), Human

Peptide YY (PYY) (3-36), Human;

Peptide YY (PYY) (3-36), Human 是一种内源性食欲抑制肽。Peptide YY (PYY) (3-36), Human,一种神经肽 Y (NPY) Y2 receptor 激动剂,是一种强效的肠道分泌抑制剂。

Peptide YY (PYY) (3-36), Humanamp;;

Peptide YY (PYY) (3-36), Human Chemical Structure

CAS No. : 123583-37-9

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion[1].

分子量

643.66

Formula

C34H34FN5O7

CAS 号

123583-37-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Moriya R, et al. NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice. Peptides. 2010;31(4):671-675.

Peptide C105Y

Peptide C105Y;

Peptide C105Y,基于 α1-抗胰蛋白酶 359-374 残基氨基酸序列合成的细胞穿透性肽,能增强 DNA 纳米粒的基因表达。

Peptide C105Yamp;;

Peptide C105Y Chemical Structure

CAS No. : 247572-63-0

规格 价格 是否有货
5 mg ¥4000 询问价格 货期
10 mg ¥6800 询问价格 货期

* Please select Quantity before adding items.

生物活性

Peptide C105Y, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles[1].

体外研究
(In Vitro)

When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1994.40

Formula

C97H148N20O23S

CAS 号

247572-63-0

Sequence

Cys-Ser-Ile-Pro-Pro-Glu-Val-Lys-Phe-Asn-Lys-Pro-Phe-Val-Tyr-Leu-Ile

Sequence Shortening

CSIPPEVKFNKPFVYLI

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Rhee M, et al. Mechanism of uptake of C105Y, a novel cell-penetrating peptide. J Biol Chem. 2006 Jan 13;281(2):1233-40.

α2β1 Integrin Ligand Peptide

α2β1 Integrin Ligand Peptide;

α2β1 Integrin Ligand Peptide在细胞膜表面与 α2β1 整合素受体相互作用,进入细胞介导细胞外信号。α2β1 Integrin Ligand Peptide是一种潜在的胶原受体拮抗剂。

α2β1 Integrin Ligand Peptideamp;;

α2β1 Integrin Ligand Peptide Chemical Structure

CAS No. : 134580-64-6

规格 价格 是否有货
1 mg ¥1200 询问价格 货期
5 mg ¥3500 询问价格 货期
10 mg ¥5500 询问价格 货期

* Please select Quantity before adding items.

alpha;2beta;1 Integrin Ligand Peptide 的其他形式现货产品:

alpha;2beta;1 Integrin Ligand Peptide TFA

生物活性

α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors[1].

分子量

390.35

Formula

C14H22N4O9

CAS 号

134580-64-6

Sequence

Asp-Gly-Glu-Ala

Sequence Shortening

DGEA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Graham KL, et al. Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha2beta1 and alphaxbeta2 integrin ligand sequences. J Virol. 2004 Nov;78(21):11786-97.

C-Peptide 2, rat

C-Peptide 2, rat;

C-Peptide 2, rat 是一种由 31 个氨基酸残基构成的多肽,是胰岛素原的一种组分。C-Peptide 2, rat 可抑制葡萄糖诱导的胰岛素分泌。

C-Peptide 2, ratamp;;

C-Peptide 2, rat Chemical Structure

CAS No. : 41594-08-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

C-Peptide 2, rat, 31-amino-acid peptide, is a component of proinsulin. C-Peptide 2, rat can inhibit glucose-induced insulin secretion[1][2].

分子量

3161.43

Formula

C135H222N38O49

CAS 号

41594-08-5

Sequence Shortening

EVEDPQVAQLELGGGPGAGDLQTLALEVARQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Toyota T, et, al. Inhibitory action of rat insulin and synthetic rat C-peptide on insulin secretion in the perfused rat pancreas. Acta Diabetol Lat. Sep-Dec 1977; 14(5-6): 250-6.

    [2]. Wójcikowski C, et, al. Effects of synthetic rat C-peptide in normal and diabetic rats. Diabetologia. 1983 Sep;25(3):288-90.

Glucagon-Like Peptide (GLP) II, human

Glucagon-Like Peptide (GLP) II, human;

Glucagon-Like Peptide (GLP) II, human 是由原胰高血糖素 C 端衍生的33 氨基酸肽,主要由肠道L细胞产生。Glucagon-Like Peptide (GLP) II 可刺激肠粘膜生长,减少肠细胞的凋亡。

Glucagon-Like Peptide (GLP) II, humanamp;;

Glucagon-Like Peptide (GLP) II, human Chemical Structure

CAS No. : 89750-15-2

规格 价格 是否有货
5 mg ¥3500 询问价格 货期
10 mg ¥5500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes [1].

IC50 Target[1]

Human Endogenous Metabolite

;

分子量

3766.20

Formula

C165H254N44O55S

CAS 号

89750-15-2

Sequence

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp

Sequence Shortening

HADGSFSDEMNTILDNLAARDFINWLIQTKITD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Drucker DJ, et al. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7911-6.

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled;

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled 是三种哺乳动物利尿钠肽 (NPs) 之一,具有内分泌作用,可以调节体内液体稳态和血压。Atrial Natriuretic Peptide 具有用于心血管疾病研究的潜力。

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeledamp;;

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled Chemical Structure

CAS No. : 1815618-06-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, one of three mammalian natriuretic peptides (NPs), has endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide has the potential for cardiovascular diseases research[1][2].

分子量

3308.80

Formula

C137H217N47O41S4

CAS 号

1815618-06-4

Sequence

Biotin-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)

Sequence Shortening

Biotin-SLRRSSCFGGRMDRIGAQSGLGCNSFRY (Disulfide bridge: Cys7-Cys23)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. S Vink, et al. Natriuretic peptide drug leads from snake venom. . 2012 Mar 15;59(4):434-45.

    [2]. Verónica Sosa, et al. Participation of glucose transporters on atrial natriuretic peptide-induced glucose uptake by adult and neonatal cardiomyocytes under oxygenation and hypoxia. Eur J Pharmacol. 2007 Jul 30;568(1-3):83-8.

G-Protein antagonist peptide

G-Protein antagonist peptide;

G-Protein antagonist peptide 是一种 substance P 相关肽,可抑制 G 蛋白与其受体的结合。G-Protein antagonist peptide 竞争性和可逆性地抑制毒蕈碱型乙酰胆碱受体 M2 (M2 muscarinic receptor) 对 Gi 或 Go 的激活,并通过 β-肾上腺素受体抑制 Gs 的激活。

G-Protein antagonist peptideamp;;

G-Protein antagonist peptide Chemical Structure

CAS No. : 143675-79-0

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.

分子量

1093.26

Formula

C5H7FN2O2W3

CAS 号

143675-79-0

Sequence

{Glp}-Gln-Trp-Phe-Trp-Trp-Met-NH2

Sequence Shortening

{Glp}QWFWWM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mukai H, et al. G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J Biol Chem. 1992;267(23):16237-16243.

Proinsulin C-Peptide (31-63), porcine

Proinsulin C-Peptide (31-63), porcine;

Proinsulin C-Peptide (31-63), porcine 是猪胰岛素原裂解产物的多肽片段。

Proinsulin C-Peptide (31-63), porcineamp;;

Proinsulin C-Peptide (31-63), porcine Chemical Structure

CAS No. : 28152-90-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Proinsulin C-Peptide (31-63), porcine is a peptide fragment of the cleavage product porcine proinsulin[1].

分子量

3340.70

Formula

C142H239N47O46

CAS 号

28152-90-1

Sequence Shortening

RREAENPQAGAVELGGGLGGLQALALEGPPQKR

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Chance RE, et, al. Porcine proinsulin: characterization and amino acid sequence. Science. 1968 Jul 12; 161(3837): 165-7.

Uty HY Peptide (246-254)

Uty HY Peptide (246-254);

Uty HY Peptide (246-254),一种 H-Y 表位 H-YDb,来源于 UTY 蛋白,可作为男性特异性移植抗原 H-Y。

Uty HY Peptide (246-254)amp;;

Uty HY Peptide (246-254) Chemical Structure

CAS No. : 261172-28-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Uty HY Peptide (246-254) 的其他形式现货产品:

Uty HY Peptide (246-254) (TFA)

生物活性

Uty HY Peptide (246-254), derived from the ubiquitously transcribed tetratricopeptide repeat gene on the Y chromosome (UTY) protein as an H-Y epitope, H-YDb, is a male-specific transplantation antigen H-Y[1].

分子量

1196.40

Formula

C53H77N15O13S2

CAS 号

261172-28-5

Sequence

Trp-Met-His-His-Asn-Met-Asp-Leu-Ile

Sequence Shortening

WMHHNMDLI

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Greenfield A, et al. An H-YDb epitope is encoded by a novel mouse Y chromosome gene. Nat Genet. 1996 Dec;14(4):474-8.