Cortagine

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Cortagine;

Cortagine 是一种选择性的促肾上腺皮质激素释放因子受体亚型 1 (CRF1) 激动剂，对 rCRF1 的 IC50 为 2.6 nM。Cortagine 在小鼠模型中具有抗焦虑和抗抑郁作用。

Cortagineamp;;

Cortagine Chemical Structure

规格 价格 是否有货
1 mg ￥4200 询问价格 货期
5 mg ￥9500 询问价格 货期
10 mg ￥15000 询问价格 货期

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生物活性

Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model[1].

IC50 Target

IC50: 2.6 nM (rCRF1)[1]
体外研究
(In Vitro)

Cortagine inhibits rCRF1 (EC50=0.18 nM) and mCRF2β (EC50=16 nM) in transfected HEK-293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4442.06

Formula

C192H323N55O63S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hossein Tezval, et al. Cortagine, a Specific Agonist of Corticotropin-Releasing Factor Receptor Subtype 1, Is Anxiogenic and Antidepressive in the Mouse Model. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9468-73.