KLD-12

发表于2024年7月27日由Whatman官网

KLD-12;

KLD-12 是一种 12 个残基的自组装肽，可以增强骨髓基质细胞 (BMSC) 的软骨分化。 KLD-12 水凝胶可以原位填充全层骨软骨缺损，改善软骨修复。

KLD-12 Chemical Structure

CAS No. : 800379-47-9

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生物活性

KLD-12 is a 12-residue self-assembling peptide that can enhance chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair^[1]^[2].

分子量

1467.79

Formula

C₆₈H₁₂₂N₁₆O₁₉

CAS 号

800379-47-9

Sequence Shortening

Ac-Lys-LDLKLDLKLDL-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Tripathi JK, et, al. Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103.

[2]. Kisiday J, et, al. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001.

LCMV GP (61-80)

发表于2024年7月27日由Whatman官网

LCMV GP (61-80);

LCMV GP (61-80) 是衍生自淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 糖蛋白 (GP) 的多肽片段，对应于 61-80 氨基酸序列。LCMV GP (61-80) 是一种特异性抗原决定簇，可以诱导 CD4⁺ T 细胞反应。

LCMV GP (61-80) Chemical Structure

CAS No. : 232598-19-5

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生物活性

LCMV GP (61-80) is a peptide fragment derived from lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), and corresponds to amino acids 61-80. LCMV GP (61-80) is a specific epitope which can induce CD4⁺ T-cell response^[1]^[2]^[3].

分子量

2290.60

Formula

C₁₀₈H₁₆₀N₂₄O₃₁

CAS 号

232598-19-5

Sequence

Gly-Leu-Lys-Gly-Pro-Asp-Ile-Tyr-Lys-Gly-Val-Tyr-Gln-Phe-Lys-Ser-Val-Glu-Phe-Asp

Sequence Shortening

GLKGPDIYKGVYQFKSVEFD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Rodriguez F, et, al. CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting. J Virol. 2001 Nov; 75(21): 10421-30.

[2]. Andargachew R, et, al. CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection. J Immunol. 2018 Jul 1; 201(1):19-30.

[3]. Homann D, et, al. Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II. Virology. 2007 Jun 20; 363(1): 113-23.

Cecropin P1, porcine

发表于2024年7月27日由Whatman官网

Cecropin P1, porcine;

Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.

Cecropin P1, porcine Chemical Structure

CAS No. : 125667-96-1

规格	价格	是否有货
1 mg	￥2900	询问价格货期
5 mg	￥6500	询问价格货期

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生物活性	Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.
分子量	3338.86
Formula	C₁₄₇H₂₅₃N₄₅O₄₃
CAS 号	125667-96-1
Sequence	Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg
Sequence Shortening	SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.

Ac-IEVDIDV TFA

发表于2024年7月26日由Whatman官网

Ac-IEVDIDV TFA;

Ac-IEVDIDV TFA 是一个短肽序列，末端是 Ac。

Ac-IEVDIDV TFA Chemical Structure

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生物活性	Ac-IEVDIDV TFA is a short peptide sequence with Ac at the end.
分子量	957.94
Formula	C₃₉H₆₂F₃N₇O₁₇
Sequence	Ac-Ile-Glu-Val-Asp-Ile-Asp-Val
Sequence Shortening	Ac-IEVDIDV
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.

Human Papillomavirus (HPV) E7 protein (49-57)

发表于2024年7月26日由Whatman官网

Human Papillomavirus (HPV) E7 protein (49-57);

Human Papillomavirus (HPV) E7 protein (49-57) 是 H-2^d 限制性人乳头瘤病毒 (HPV) E7_49-57 表位（即在 E7 蛋白中跨越 49 到 57 个氨基酸残基的短肽）。

Human Papillomavirus (HPV) E7 protein (49-57) Chemical Structure

CAS No. : 151812-18-9

规格		是否有货
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生物活性	Human Papillomavirus (HPV) E7 protein (49-57) is the H-2^d-restricted human papillomavirus (HPV) E7_49-57 epitope (short peptide spanning the 49th to 57th amino acid residues in the E7 protein)^[1].
分子量	1120.26
Formula	C₅₂H₇₇N₁₅O₁₃
CAS 号	151812-18-9
Sequence	Arg-Ala-His-Tyr-Asn-Ile-Val-Thr-Phe
Sequence Shortening	RAHYNIVTF
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Ding Z, et al. Cytolytic activity of the human papillomavirus type 16 E711-20 epitope-specific cytotoxic T lymphocyte is enhanced by heat shock protein 110 in HLA-A*0201 transgenic mice. Clin Vaccine Immunol. 2013 Jul;20(7):1027-33.

CEF7, Influenza Virus NP (380-388)

发表于2024年7月26日由Whatman官网

CEF7, Influenza Virus NP (380-388);

CEF7, Influenza Virus NP (380-388) 是一种 HLA-B^*08 限制性流感病毒核蛋白表位。Influenza virus NP 在病毒和宿主细胞过程中起着关键的衔接分子的作用。

CEF7, Influenza Virus NP (380-388) Chemical Structure

CAS No. : 147100-46-7

规格		是否有货
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生物活性	CEF7, Influenza Virus NP (380-388) is a HLA-B^*08 restricted influenza virus nucleoprotein epitope. Influenza virus NP functions as a key adapter molecule between virus and host cell processes^[1]^[2].
分子量	1193.35
Formula	C₅₅H₈₄N₁₆O₁₄
CAS 号	147100-46-7
Sequence Shortening	ELRSRYWAI
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Portela A, et al. The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication. J Gen Virol. 2002 Apr;83(Pt 4):723-34. [2]. Boon AC, et al. The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype. J Virol. 2002 Jan;76(2):582-90.

Secretoneurin, rat

发表于2024年7月26日由Whatman官网

Secretoneurin, rat;

Secretoneurin, rat 是由分泌粒蛋白 II (SgII) 的蛋白水解过程产生的一种 33 个氨基酸多肽。Secretoneurin, rat 在体内和体外诱导大鼠纹状体多巴胺释放，对单核细胞和嗜酸性粒细胞有很强的趋化作用，而对粒细胞则没有。

Secretoneurin, rat Chemical Structure

CAS No. : 149146-12-3

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生物活性	Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat induces dopamine release in the rat striatum in vivo and in vitro, and it exerts a very strong chemotactic effect on monocytes and eosinophils but not on granulocytes^[1].
分子量	3651.95
Formula	C₁₅₉H₂₅₂N₄₀O₅₈
CAS 号	149146-12-3
Sequence	Thr-Asn-Glu-Ile-Val-Glu-Glu-Gln-Tyr-Thr-Pro-Gln-Ser-Leu-Ala-Thr-Leu-Glu-Ser-Val-Phe-Gln-Glu-Leu-Gly-Lys-Leu-Thr-Gly-Pro-Ser-Asn-Gln
Sequence Shortening	TNEIVEEQYTPQSLATLESVFQELGKLTGPSNQ
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Troger J, et al. Secretoneurin in the peripheral ocular innervation. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):647-54.

CKLF1-C27

发表于2024年7月26日由Whatman官网

CKLF1-C27;

CKLF1-C27 是 CKLF1 的 C 末端肽，与 CCR4 受体结合并激活 ERK1/2 通路。CKLF1-C27 可以通过竞争 CCR4 受体来消除 CKLF1 对细胞的影响。CKLF1-C27对促进HUVECs增殖有很大的作用。CKLF1-C27 具有用于银屑病研究的潜力。

CKLF1-C27 Chemical Structure

CAS No. : 891861-48-6

规格		是否有货
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生物活性

CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research^[1].

IC₅₀ Target^[1]

CCR4

;

ERK1

;

ERK2

;

分子量

3196.78

Formula

C₁₅₁H₂₄₃N₃₉O₃₇

CAS 号

891861-48-6

Sequence Shortening

ALIYRKLLFNPSGPYQKKPVHEKKEVL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Yaqi Tan, et al. Chemokine-like factor 1-derived C-terminal peptides induce the proliferation of dermal microvascular endothelial cells in psoriasis. PLoS One. 2015 Apr 27;10(4):e0125073.

Tyroserleutide hydrochloride(Synonyms: 酪丝亮肽盐酸盐)

发表于2024年7月26日由Whatman官网

Tyroserleutide hydrochloride;(Synonyms: 酪丝亮肽盐酸盐) 纯度: 99.47%

Tyroserleutide hydrochloride 可从猪脾脏的降解产物中分离得到，是一种小分子三肽，在体内外均可抑制肿瘤生长。

Tyroserleutide hydrochlorideamp;;(Synonyms: 酪丝亮肽盐酸盐)

Tyroserleutide hydrochloride Chemical Structure

CAS No. : 852982-42-4

规格	价格	是否有货	数量
1 mg	￥1100	In-stock
5 mg	￥2300	In-stock
10 mg	￥4000	In-stock
25 mg	￥7500	In-stock
50 mg	￥11500	In-stock
100 mg	￥19500	In-stock
200 mg	;	询价	;
500 mg	;	询价	;

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Tyroserleutide hydrochloride 相关产品

bull;相关化合物库:

Drug Repurposing Compound Library Plus
Clinical Compound Library Plus
Bioactive Compound Library Plus
Peptide Library

生物活性

Tyroserleutide hydrochloride, isolated from the degradation products of porcine spleen^[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo^[2].

IC₅₀ Target

Antitumor tripeptide^[1]^[2]

体外研究
(In Vitro)

Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells^[1].
Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression^[2].
Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells^[2].
Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model^[1]
Dosage:	10, 20, 40, and 80 μg/kg
Administration:	Injection (i.p.) one time every day until mice were dead.
Result:	Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively.

Clinical Trial

分子量

417.88

Formula

C₁₈H₂₈ClN₃O₆

CAS 号

852982-42-4

中文名称

酪丝亮肽盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:;

DMSO : 250 mg/mL (598.26 mM; Need ultrasonic)

H₂O : 2 mg/mL (4.79 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3930 mL	11.9652 mL	23.9303 mL
5 mM	0.4786 mL	2.3930 mL	4.7861 mL
10 mM	0.2393 mL	1.1965 mL	2.3930 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.98 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.98 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.98 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Wang C, et al. Studies on the large scale synthesis and anti-tumor activity of YSL. Prep Biochem Biotechnol. 2003 Aug;33(3):189-95.

[2]. Liang P, et al. pH-Triggered Conformational Change of Antp-Based Drug Delivery Platform for Tumor Treatment with Combined Photothermal Therapy and Chemotherapy. Adv Healthc Mater. 2019 Aug;8(15):e1900306.

β-Amyloid (1-34)

发表于2024年7月26日由Whatman官网

β-Amyloid (1-34);

β-Amyloid (1-34) 是 β 淀粉样蛋白的多肽，由 34 个氨基酸组成。

β-Amyloid (1-34) Chemical Structure

CAS No. : 186359-65-9

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

β-Amyloid (1-34) is a β-Amyloid peptide consists of 34 amino acid.

分子量

3787.20

Formula

C₁₇₀H₂₅₃N₄₇O₅₂

CAS 号

186359-65-9

Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu

Sequence Shortening

DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Fluhrer R, et al. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. J Biol Chem. 2003 Feb 21;278(8):5531-8.

Cytiva思拓凡-Whatman滤纸滤膜滤器

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