分类目录归档：多肽产品

Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Spiraeoside;(Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside 是具有口服活性的天然产物，具有抗氧化活性，抑制活性氧和丙二醛的生成。Spiraeoside 具有抗过敏、抗炎、抗肿瘤活性。

Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside Chemical Structure

CAS No. : 20229-56-5

规格 价格 是否有货
5 mg ￥5700 询问价格 货期
10 mg ￥9500 询问价格 货期

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生物活性

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].

体外研究
(In Vitro)

Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002)[1].
Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis[1].
Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG[1].
Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: AC16 cells.
Concentration: 1, 5, 10, or 20 μM.
Incubation Time: 0, 24, or 48 hours.
Result: Inhibited AC16 cells viability (20 μM).

体内研究
(In Vivo)

Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (6-8 weeks old)[2].
Dosage: 50 mg/kg.
Administration: Oral gavage an hour before inducing the lesions.
Result: Decreased severity of the formed lesions.

分子量

464.38

Formula

C21H20O12
CAS 号

20229-56-5
中文名称

螺旋藻苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22548.

    [2]. Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.

Gluten Exorphin C

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Gluten Exorphin C; 纯度: 98.97%

Gluten exorphin C 是一种源自谷朊粉的阿片肽。在 GPI 和 MVD 检测中，抑制 μ opioid 和 δ opioid 活性，IC50 值分别为 40 μM 和13.5 μM。

Gluten Exorphin Camp;;

Gluten Exorphin C Chemical Structure

CAS No. : 142479-62-7

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1 mg ￥1100 In-stock
5 mg ￥1900 In-stock
10 mg ￥2900 In-stock
25 mg ￥5900 In-stock
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生物活性

Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

IC50 Target

IC50: 40 μM (μ opioid), 13.5 μM (δ opioid)[1]
体外研究
(In Vitro)

Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC50s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

591.70

Formula

C29H45N5O8
CAS 号

142479-62-7
Sequence

Tyr-Pro-Ile-Ser-Leu
Sequence Shortening

YPISL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (169.00 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6900 mL 8.4502 mL 16.9005 mL
5 mM 0.3380 mL 1.6900 mL 3.3801 mL
10 mM 0.1690 mL 0.8450 mL 1.6900 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fukudome S, et al. Gluten exorphin C. A novel opioid peptide derived from wheat gluten. FEBS Lett. 1993 Jan 18;316(1):17-9.

Dipsanoside B(Synonyms: 续断苷 B)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Dipsanoside B;(Synonyms: 续断苷 B)

Dipsanoside B 是一种来自川续断 (Dipsacus asper) 的新型四环苷类葡萄糖苷。川续断是一种在中国广泛存在的多年生植物，被用于传统中药中已有数百年，可以作为补品，作为骨质细胞的分裂促进剂，以及胚胎安全剂等。

Dipsanoside B(Synonyms: 续断苷 B)

Dipsanoside B Chemical Structure

CAS No. : 889678-64-2

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生物活性

Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc[1].

分子量

1475.40

Formula

C66H90O37
CAS 号

889678-64-2
中文名称

续断苷 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tian, X.-Y. et al. Two Novel Tetrairidoid Glucosides from Dipsacus asper. Organic Letters, 2006,8(10), 2179–2182.

TRV120056

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TRV120056;

TRV120056 是一种偏向 Gq 的激动剂，在 AT1R-Gq 融合蛋白上的分子效率是 AT1R-βarr2 融合蛋白的 10 倍。

TRV120056amp;;

TRV120056 Chemical Structure

CAS No. : 40678-47-5

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1 mg ￥500 In-stock
5 mg ￥900 In-stock
10 mg ￥1500 In-stock
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TRV120056 相关产品

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生物活性

TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].

分子量

956.06

Formula

C43H65N13O12
CAS 号

40678-47-5
Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Gly
Sequence Shortening

DRVYIHPG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 33.33 mg/mL (34.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0460 mL 5.2298 mL 10.4596 mL
5 mM 0.2092 mL 1.0460 mL 2.0919 mL
10 mM 0.1046 mL 0.5230 mL 1.0460 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77.

    [2]. Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24.

OJV-VI

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天然产物 糖类和糖苷 Saccharides and Glycosides

OJV-VI;

OJV-VI 是存在于麦冬属植物中的天然产物。

OJV-VI

OJV-VI Chemical Structure

CAS No. : 125150-67-6

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生物活性

OJV-VI is found in ophiopogonis[1].

分子量

855.02

Formula

C44H70O16
CAS 号

125150-67-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Asano T, Murayama T, Hirai Y, Shoji J. Comparative studies on the constituents of ophiopogonis tuber and its congeners. VIII. Studies on the glycosides of the subterranean part of Ophiopogon japonicus Ker-Gawler cv. Nanus. Chem Pharm Bull (Tokyo). 1993;41

Arg-Gly-Asp-Cys TFA

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Arg-Gly-Asp-Cys TFA;

Arg-Gly-Asp-Cys TFA 是纤维粘连蛋白与细胞粘附分子的结合基序，能够抑制血小板凝集以及纤维蛋白原结合。

Arg-Gly-Asp-Cys TFAamp;;

Arg-Gly-Asp-Cys TFA Chemical Structure

CAS No. : 2171504-22-4

规格 价格 是否有货 数量
5 mg ￥770 In-stock
10 mg ￥1250 In-stock
25 mg ￥2500 In-stock
50 mg ; 询价 ;
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Arg-Gly-Asp-Cys TFA 相关产品

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生物活性

Arg-Gly-Asp-Cys TFA is the binding motif of fibronectin to cell adhesion molecules. Arg-Gly-Asp-Cys TFA can inhibit platelet aggregation and fibrinogen binding[1].

体外研究
(In Vitro)

Arg-Gly-Asp-Cys-functionalized chitosan (0.25-1 mg/mL; 2-7 days) favors cell growth and an increase in cellular proliferation compared to the control cells (viability >140%)[1].
Arg-Gly-Asp-Cys-functionalizes chitosan derivatives exhibit in vitro wound healing properties by enhancing fibroblast proliferation and adhesion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

563.51

Formula

C17H28F3N7O9S
CAS 号

2171504-22-4
Sequence Shortening

RGDC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light, stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:;

H2O : 250 mg/mL (443.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7746 mL 8.8730 mL 17.7459 mL
5 mM 0.3549 mL 1.7746 mL 3.5492 mL
10 mM 0.1775 mL 0.8873 mL 1.7746 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Patrulea V, et, al. Peptide-decorated chitosan derivatives enhance fibroblast adhesion and proliferation in wound healing. Carbohydr Polym. 2016 May 20;142:114-23.

Fructo-​oligosaccharide DP7/GF6(Synonyms: 蔗果七糖)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Fructo-​oligosaccharide DP7/GF6;(Synonyms: 蔗果七糖)

Fructo-oligosaccharide DP7/GF6 属于聚果糖，聚合度 (DP=7)。Fructo-oligosaccharides (FOS) 由 6 个果糖单元通过 (2→1)-β-糖苷键连接，并在非还原性末端具有 1 个 D-葡萄糖单元。

Fructo-​oligosaccharide DP7/GF6(Synonyms: 蔗果七糖)

Fructo-​oligosaccharide DP7/GF6 Chemical Structure

CAS No. : 62512-20-3

规格 价格 是否有货 数量
5 mg ￥3030 In-stock
10 mg ￥5140 In-stock
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Fructo-​oligosaccharide DP7/GF6 相关产品

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生物活性

Fructo-oligosaccharide DP7/GF6 belongs to fructooligosaccharides (FOS) with degree of polymerization (DP=7). Fructo-oligosaccharides (FOS) are composed of 6 fructose units linked by (2→1)-β-glycosidic bonds and having a single D-glucosyl unit at the non-reducing end[1].

分子量

1153.00

Formula

C42H72O36
CAS 号

62512-20-3
中文名称

蔗果七糖
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Martins GN, et al. Technological Aspects of the Production of Fructo and Galacto-Oligosaccharides. EnzymaticSynthesis and Hydrolysis. Front Nutr. 2019 May 31;6:78.

LRGILS-NH2 TFA

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LRGILS-NH2 TFA; 纯度: 98.15%

LRGILS-NH2 TFA 是一个反向序列蛋白酶激活受体-2 (PAR-2) 不活跃的，阴性对照。SLIGRL-NH2 则是 PAR-2 激活肽。

LRGILS-NH2 TFAamp;;

LRGILS-NH2 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥600 In-stock
5 mg ￥1800 In-stock
10 mg ￥2900 In-stock
50 mg ; 询价 ;
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生物活性

LRGILS-NH2 TFA is a reverse-sequence protease-activated receptor-2 (PAR-2)-inactive, negative control, and SLIGRL-NH2 is a PAR-2-activating peptide[1].

分子量

770.84

Formula

C31H57F3N10O9
Sequence Shortening

LRGILS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : ≥ 100 mg/mL (129.73 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2973 mL 6.4864 mL 12.9729 mL
5 mM 0.2595 mL 1.2973 mL 2.5946 mL
10 mM 0.1297 mL 0.6486 mL 1.2973 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.24 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Nishikawa H, Kawai K, Tanaka M, et al. Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms. J Pharmacol Exp Ther. 2005;312(1):324-331.

Gentianose

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天然产物 糖类和糖苷 Saccharides and Glycosides

Gentianose;

Gentianose 是多年生黄龙胆贮藏根中主要的碳水化合储备物。

Gentianose

Gentianose Chemical Structure

CAS No. : 25954-44-3

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生物活性

Gentianose is a predominant carbohydrate reserve found in the storage roots of perennial Gentiana lutea[1].

分子量

504.44

Formula

C18H32O16
CAS 号

25954-44-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Imperio D, et al. Gentianose: Purification and structural determination of an unknown oligosaccharide in grape seeds. Food Chem. 2021;344:128588.

Vapreotide acetate(Synonyms: RC-160 acetate BMY-41606 acetate)

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Vapreotide acetate;(Synonyms: RC-160 acetate; BMY-41606 acetate) 纯度: 99.67%

Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) 是 神经激肽-1 (NK1) 受体拮抗剂，其 IC50 值为 330 nM。

Vapreotide acetateamp;;(Synonyms: RC-160 acetate; BMY-41606 acetate)

Vapreotide acetate Chemical Structure

CAS No. : 849479-74-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
5 mg ￥2000 In-stock
10 mg ￥2800 In-stock
25 mg ￥5000 In-stock
50 mg ￥9000 In-stock
100 mg ￥13000 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.

体外研究
(In Vitro)

Vapreotide attenuates the Substance P (SP)-triggered intracellular calcium increases and NF-κB activation in a dose-dependent manner. Vapreotide also inhibits SP-induced IL-8 and MCP-1 production in HEK293-NK1R and U373MG cell lines. Vapreotide inhibits HIV-1 infection of human MDM in vitro, an effect that is reversible by SP pretreatment[1]. Vapreotide significantly inhibits GH-, PRL, and/or alpha-subunit release by human GH-secreting pituitary adenoma cells in concentrations as low as 10-12-10-14 M. Vapreotide inhibits GH release with an IC50 of 0.1 pM[2]. Vapreotide exhibits moderate-to-high affinities for SSTR2, -3, and -5 (IC50=0.17, 0.1 and 21 nM, respectively) and low affinity for SSTR1 and -4 (IC50=200 and 620 nM, respectively). RC-160 inhibits serum-induced proliferation of CHO cells expressing SSTR2 and SSTR5 (EC50=53 and 150 pM, respectively)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In cirrhosis, bleeding by rupture of oesophagogastric varices is a severe complication of portal hypertension. The acute administration of vapreotide to rats decreases collateral circulation blood flow while chronic administration attenuated its development[4]. Tumor volumes and weights are reduced by about 40% by RC-160 by s.c. injections at doses of 100 μg/day/animal. Vapreotide can inhibit the growth of androgen-independent prostate cancer when the therapy is started at an early stage of tumor development[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

1191.39

Formula

C57H70N12O9S2.xC2H4O2
CAS 号

849479-74-9
中文名称

醋酸伐普肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 14.29 mg/mL (11.99 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8394 mL 4.1968 mL 8.3936 mL
5 mM 0.1679 mL 0.8394 mL 1.6787 mL
10 mM 0.0839 mL 0.4197 mL 0.8394 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Spitsin S, et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55.

    [2]. Hofland LJ, et al. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on theinhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Endocrinology. 1994 Jan;134(1):301-6.

    [3]. Buscail L, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1580-4.

    [4]. Veal N, et al. Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis. Dig Dis Sci. 2003 Jan;48(1):154-61.

    [5]. Pinski J, et al. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.
Cell Assay
[3]

CHO cells are cultured in aMEM containing 10% FCS. After overnight attachment, the medium is changed to a MEM containing either 10% FCS or insulin with and without vapreotide. Cell growth is measured after 24 h by counting cells with a Coulter counter model ZM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4][5]

Rats: Acute effects are evaluated at baseline and 30 min after placebo or vapreotide (8 μg/kg/hr) infusions in DMNA rats. Chronic hemodynamic effects are evaluated using subcutaneous implants for five weeks in anesthetized DMNA rats and in sham rats. Hemodynamic measurements include splenorenal shunt blood flow by the transit time ultrasound method and cardiac output by the combined dilution–TTU method[4].

Mice: Nude mice bearing xenografts of the androgen-independent human prostate-cancer cell line PC-3 are treated for 4 weeks with somatostatin analog vapreotide (20 μg/day/animal), bombesin/gastrin-releasing peptide (GRP) antagonist, or the combination of both peptides. Tumor volumes and weights are measured[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Spitsin S, et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55.

    [2]. Hofland LJ, et al. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on theinhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Endocrinology. 1994 Jan;134(1):301-6.

    [3]. Buscail L, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1580-4.

    [4]. Veal N, et al. Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis. Dig Dis Sci. 2003 Jan;48(1):154-61.

    [5]. Pinski J, et al. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.