(Cys47)-HIV-1 tat Protein (47-57)

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(Cys47)-HIV-1 tat Protein (47-57);

(Cys47)-HIV-1 tat Protein (47-57) 具有膜移位功能，可用于衍生磁性药物的表面，并促进其被吸收到靶细胞中。

(Cys47)-HIV-1 tat Protein (47-57)amp;;

(Cys47)-HIV-1 tat Protein (47-57) Chemical Structure

CAS No. : 627079-23-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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生物活性

(Cys47)-HIV-1 tat Protein (47-57) has membrane translocation function and can be used to derivatize the surface of magnetic pharmaceuticals and substantially facilitated their uptake into target cells[1][2].

分子量

1499.80

Formula

C58H114N32O13S
CAS 号

627079-23-6
Sequence

Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
Sequence Shortening

CGRKKRRQRRR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Chumki Dalal, et al. Multivalency Effect of TAT-Peptide-Functionalized Nanoparticle in Cellular Endocytosis and Subcellular Trafficking. J Phys Chem B. 2017 Apr 13;121(14):2942-2951.

    [2]. Ming Zhao, et al. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. Jul-Aug 2002;13(4):840-4.