Ceratotoxin B(Synonyms: 角朊毒素B)

发表于2024年8月4日由Whatman官网

Ceratotoxin B;(Synonyms: 角朊毒素B)

Ceratotoxin B 是一种是一种由性成熟的雌性地中海实蝇 (Ceratitis capitata) 产生的抗菌肽，有溶解性和抗菌活性。

Ceratotoxin B Chemical Structure

CAS No. : 150671-05-9

规格		是否有货
5 mg		询价
10 mg		询价
25 mg		询价

* Please select Quantity before adding items.

生物活性	Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity ^[1].
IC₅₀ Target	Bacterial^[1]
分子量	2860.53
Formula	C₁₃₅H₂₃₅N₃₅O₃₂
CAS 号	150671-05-9
Sequence	Ser-Ile-Gly-Ser-Ala-Phe-Lys-Lys-Ala-Leu-Pro-Val-Ala-Lys-Lys-Ile-Gly-Lys-Ala-Ala-Leu-Pro-Ile-Ala-Lys-Ala-Ala-Leu-Pro
Sequence Shortening	SIGSAFKKALPVAKKIGKAALPIAKAALP
中文名称	角朊毒素B
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Marchini D, et al. Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata (Insecta:Diptera). Insect Biochem Mol Biol. 1993 Jul;23(5):591-8.

Angiopeptin(Synonyms: 血管抑肽)

发表于2024年8月1日由Whatman官网

Angiopeptin;(Synonyms: 血管抑肽)

Angiopeptin 是生长抑素的环状八肽类似物，是一种 sst₂/sst₅ 受体部分激动剂，IC₅₀ 值分别为 0.26 nM 和 6.92 nM。Angiopeptin 可以抑制生长激素释放和胰岛素样生长因子-1 (IGF-1) 产生。Angiopeptin 抑制腺苷酸环化酶或刺激细胞外酸化。Angiopeptin 具有用于冠状动脉粥样硬化研究的潜力。

Angiopeptin Chemical Structure

CAS No. : 113294-82-9

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Angiopeptin 的其他形式现货产品:

Angiopeptin TFA

生物活性	Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research^[1]^[2].
IC₅₀ Target	IC50: 0.26 nM (sst2) and 6.92 nM (sst5)^[1]^[2]
体外研究 (In Vitro)	Angiopeptin (0.1 nM- 10 μM; for 1 h) acts as a partial agonist (pEC₅₀=6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst₂ cells^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Angiopeptin (20 and 50μg/kg; i.h.) significantly inhibits neointimal formation^[1]. Angiopeptin (20 μg/kg; per day) significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1098.34
Formula	C₅₄H₇₁N₁₁O₁₀S₂
CAS 号	113294-82-9
Sequence Shortening	{Nal}CYWKVCT-NH2
中文名称	血管抑肽
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lundergan CF, et al. Peptide inhibition of myointimal proliferation by angiopeptin, a somatostatin analogue. J Am Coll Cardiol. 1991;17(6 Suppl B):132B-136B. [2]. Alderton F, et al. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001;132(3):760-766.

Catestatin(Synonyms: 酪蛋白)

发表于2024年7月27日由Whatman官网

Catestatin;(Synonyms: 酪蛋白)

Catestatin 是一种含 21 个氨基酸残基的，阳离子的疏水肽。Catestatin 是一种内源肽，可调节心脏功能和血压。Catestatin 是一种非竞争性的烟碱类拮抗剂，可通过烟碱型乙酰胆碱受体 (nAChRs) 抑制儿茶酚胺的释放。

Catestatin Chemical Structure

CAS No. : 142211-96-9

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Catestatin 的其他形式现货产品:

Catestatin TFA

生物活性

Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. Catestatin is an endogenous peptide that regulates cardiac function and blood pressure^[1]. Catestatin is a non-competitive nicotinic antagonist acting through nicotinic acetylcholine receptors (nAChRs) to inhibit catecholamine release^[2].

分子量

2425.82

Formula

C₁₀₇H₁₇₃N₃₇O₂₆S

CAS 号

142211-96-9

Sequence

Arg-Ser-Met-Arg-Leu-Ser-Phe-Arg-Ala-Arg-Gly-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Leu-Gln-Leu

Sequence Shortening

RSMRLSFRARGYGFRGPGLQL

中文名称

酪蛋白

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Nitish R Mahapatra. Catestatin Is a Novel Endogenous Peptide That Regulates Cardiac Function and Blood Pressure. Cardiovasc Res. 2008 Dec 1;80(3):330-8.

[2]. Sebastian Kraszewski, et al. A Molecular Dynamics Study of Catestatin Docked on Nicotinic Acetylcholine Receptors to Identify Amino Acids Potentially Involved in the Binding of Chromogranin A Fragments. Phys Chem Chem Phys. 2015 Jul 14;17(26):17454-60.

Pramlintide(Synonyms: 普兰林肽)

发表于2024年7月25日由Whatman官网

Pramlintide;(Synonyms: 普兰林肽)

Pramlintide 是一种人胰淀粉样多肽类似物。Pramlintide 是一种抗糖尿病剂，也可用于肠癌的研究。

Pramlintide Chemical Structure

CAS No. : 151126-32-8

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Pramlintide 的其他形式现货产品:

Pramlintide acetate

生物活性

Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer^[1].

体外研究
(In Vitro)

Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC₅₀s of 48.67 and 9.10 μg/mL, respectively)^[1].
The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

3951.46

Formula

C₁₇₁H₂₆₉N₅₁O₅₃S₂

CAS 号

151126-32-8

Sequence

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-NH2 (Disulfide bridge:Cys2-Cys7)

Sequence Shortening

KCNTATCATQRLANFLVHSSNNFGPILPPTNVGSNTY-NH2 (Disulfide bridge:Cys2-Cys7)

中文名称

普兰林肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29.

Phytochelatin 5(Synonyms: PC 5)

发表于2024年7月15日由Whatman官网

Phytochelatin 5;(Synonyms: PC 5)

Phytochelatin 5 是植物产生的金属结合化合物。Phytochelatin 5 可能会降低膳食有毒金属 (如镉) 的生物利用度。

Phytochelatin 5 Chemical Structure

CAS No. : 99465-97-1

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Phytochelatin 5 is metal-binding compound produced by plants. Phytochelatin 5 may reduce bioavailability of dietary toxic metals such as cadmium^[1].
分子量	1236.35
Formula	C₄₂H₆₅N₁₁O₂₂S₅
CAS 号	99465-97-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Dennis KK, et al. Distribution of phytochelatins, metal-binding compounds, in plant foods: A survey of commonly consumed fruits, vegetables, grains and legumes. Food Chem. 2021;339:128051.

Phytochelatin 6(Synonyms: PC 6)

发表于2024年7月14日由Whatman官网

Phytochelatin 6;(Synonyms: PC 6)

Phytochelatin 6 是植物产生的金属结合化合物。Phytochelatin 6 可能会降低膳食有毒金属 (如镉) 的生物利用度。

Phytochelatin 6 Chemical Structure

CAS No. : 99478-30-5

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性	Phytochelatin 6 is metal-binding compound produced by plants. Phytochelatin 6 may reduce bioavailability of dietary toxic metals such as cadmium^[1].
分子量	1468.61
Formula	C₅₀H₇₇N₁₃O₂₆S₆
CAS 号	99478-30-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Dennis KK, et al. Distribution of phytochelatins, metal-binding compounds, in plant foods: A survey of commonly consumed fruits, vegetables, grains and legumes. Food Chem. 2021;339:128051.

Gly6(Synonyms: Hexaglycine)

发表于2024年7月3日由Whatman官网

Gly6;(Synonyms: Hexaglycine)

Gly6 (Hexaglycine) 是一种具有六个甘氨酸的线性甘氨酸寡肽。

Gly6 Chemical Structure

CAS No. : 3887-13-6

规格	价格	是否有货
5 mg	￥1200	询问价格货期

* Please select Quantity before adding items.

生物活性

Gly6 (Hexaglycine) is a linear glycine oligopeptide with six glycines^[1]^[2].

体外研究
(In Vitro)

The mode of action of zoocin A against sensitive streptococci is lytic, that lysis occurs as a direct result of the interaction of zoocin A with the cell, and that zoocin A and lysostaphin are both capable of cleaving the peptide substrate Gly6 (Hexaglycine)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

360.32

Formula

C₁₂H₂₀N₆O₇

CAS 号

3887-13-6

Sequence

Gly-Gly-Gly-Gly-Gly-Gly

Sequence Shortening

GGGGGG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. R S Simmonds, et al. Mode of Action of a Lysostaphin-Like Bacteriolytic Agent Produced by Streptococcus Zooepidemicus 4881. Appl Environ Microbiol. 1996 Dec;62(12):4536-41.

[2]. S A Adibi, et al. The Number of Glycine Residues Which Limits Intact Absorption of Glycine Oligopeptides in Human Jejunum. J Clin Invest. 1977 Nov;60(5):1008-16.

Apamin(Synonyms: Apamine)

发表于2024年7月2日由Whatman官网

Apamin;(Synonyms: Apamine)

Apamin (Apamine) 是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素，是一种 Ca²⁺ 激活的 K⁺ (SK) 通道的特异性和选择性的阻断剂，具有抗炎和抗纤维化的作用。

Apamin Chemical Structure

CAS No. : 24345-16-2

规格	价格	是否有货
500 μg	￥1500	询问价格货期
1 mg	￥2500	询问价格货期

* Please select Quantity before adding items.

Apamin 的其他形式现货产品:

Apamin TFA

生物活性

Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca²⁺-activated K⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity^[1].

IC₅₀ Target

K⁺ channel^[1]

体外研究
(In Vitro)

Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HSC-T6 cells
Concentration:	0.5 µg/mL, 1 µg/mL and 2 µg/mL
Incubation Time:	24 hours
Result:	Markedly reduced the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Abrogated the activation of p-Smad2/3 and Smad4 induced by TGF-β1.

体内研究
(In Vivo)

Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-week-old C57BL/6 male mice (20-25 g) with DDC feeding^[1]
Dosage:	0.1 mg/kg
Administration:	Intraperitoneal injection; twice a week; for 4 weeks
Result:	Resulted in decreased liver injury and proinflammatory cytokine levels. Suppressed the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the DDC-fed mice.

分子量

2027.34

Formula

C₇₉H₁₃₁N₃₁O₂₄S₄

CAS 号

24345-16-2

Sequence

Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15)

Sequence Shortening

CNCKAPETALCARRCQQH-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15)

中文名称

蜂毒明肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kim JY, et al. Apamin suppresses biliary fibrosis and activation of hepatic stellate cells. Int J Mol Med. 2017 May;39(5):1188-1194.

Histatin 5(Synonyms: 富组蛋白5)

发表于2024年7月1日由Whatman官网

Histatin 5;(Synonyms: 富组蛋白5)

Histatin 5 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性，IC₅₀ 分别为 0.57 和 0.25 μM。

Histatin 5 Chemical Structure

CAS No. : 115966-68-2

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

Histatin 5 的其他形式现货产品:

Histatin 5 TFA

生物活性

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.

IC₅₀ Target

IC50: 0.57 μM (MMP-2), 0.25 μM (MMP-9)^[1]

体外研究
(In Vitro)

Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC₅₀, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the K_m with a K_i of 15 μM^[1]. Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 μM inhibits state 2 respiration^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3036.29

Formula

C₁₃₃H₁₉₅N₅₁O₃₃

CAS 号

115966-68-2

Sequence

Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr

Sequence Shortening

DSHAKRHHGYKRKFHEKHHSHRGY

中文名称

富组蛋白5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Gusman H, et al. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontaldisease. Infect Immun. 2001 Mar;69(3):1402-8.

[2]. Helmerhorst EJ, et al. The human salivary peptide histatin 5 exerts its antifungal activity through the formation ofreactive oxygen species. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42.

Bradykinin (1-7)(Synonyms: Bradykinin Fragment 1-7)

发表于2024年6月27日由Whatman官网

Bradykinin (1-7);(Synonyms: Bradykinin Fragment 1-7)

Bradykinin (1-7) 是一种氨基截短的激肽肽。Bradykinin (1-7) 是由内肽酶切割形成的一种 Bradykinin 代谢物。

Bradykinin (1-7)amp;;(Synonyms: Bradykinin Fragment 1-7)

Bradykinin (1-7) Chemical Structure

CAS No. : 23815-87-4

规格	价格	是否有货
5 mg	￥1500	询问价格货期
10 mg	￥2400	询问价格货期

* Please select Quantity before adding items.

生物活性	Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.
体外研究 (In Vitro)	The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	756.85
Formula	C₃₅H₅₂N₁₀O₉
CAS 号	23815-87-4
Sequence	Arg-Pro-Pro-Gly-Phe-Ser-Pro
Sequence Shortening	RPPGFSP
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Cytiva思拓凡-Whatman滤纸滤膜滤器

沃特曼官网代理商|Whatman滤纸滤膜中国官网代理商

标签归档：synonyms

Ceratotoxin B(Synonyms: 角朊毒素B)

Angiopeptin(Synonyms: 血管抑肽)

Catestatin(Synonyms: 酪蛋白)

Pramlintide(Synonyms: 普兰林肽)

Phytochelatin 5(Synonyms: PC 5)

Phytochelatin 6(Synonyms: PC 6)

Gly6(Synonyms: Hexaglycine)

Apamin(Synonyms: Apamine)

Histatin 5(Synonyms: 富组蛋白5)

Bradykinin (1-7)(Synonyms: Bradykinin Fragment 1-7)

2024年 9月
一	二	三	四	五	六	日
						1
2	3	4	5	6	7	8
9	10	11	12	13	14	15
16	17	18	19	20	21	22
23	24	25	26	27	28	29
30