标签归档：synonyms

Ilexhainanoside D(Synonyms: 海南冬青苷D)

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Ilexhainanoside D (Synonyms: 海南冬青苷D)

Ilexhainanoside D 是从 Ilex hainanensis Merr. 中提取的主要三萜皂苷，Ilexhainanoside D 和 Ilexsaponin A1 联合使用后具有抗炎的作用。

Ilexhainanoside D(Synonyms: 海南冬青苷D)

Ilexhainanoside D Chemical Structure

CAS No. : 1137648-52-2

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生物活性

Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect[1].

体内研究
(In Vivo)

The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240 mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes/Bacteroidetes, reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia. The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

664.82

Formula

C36H56O11
CAS 号

1137648-52-2
中文名称

海南冬青苷D
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhao W, et al. The combination of Ilexhainanoside D and ilexsaponin A1 reduces liver inflammation and improves intestinal barrier function in mice with high-fat diet-induced non-alcoholic fatty liver disease. Phytomedicine. 2019 Jul 26;63:153039.

Edpetiline(Synonyms: 西贝母碱苷)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Edpetiline;(Synonyms: 西贝母碱苷)

Edpetiline 是一种来自 P. eduardi 的主要生物碱。Edpetiline 具有明显的抗炎作用。

Edpetiline(Synonyms: 西贝母碱苷)

Edpetiline Chemical Structure

CAS No. : 32685-93-1

规格 价格 是否有货
5 mg ￥2020 询问价格 货期
10 mg ￥3430 询问价格 货期

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生物活性

Edpetiline is a principal alkaloid from P. eduardi. Edpetiline has significant antiinflammatory effects[1].

分子量

591.78

Formula

C33H53NO8
CAS 号

32685-93-1
中文名称

西贝母碱苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Shakirova, et al. Accumulation Dynamics of Alkaloids in Petilium eduardi. Chemistry of Natural Compounds, 2003, 39(6), 603–604.

Brassicasterol(Synonyms: 油菜甾醇)

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Brassicasterol (Synonyms: 油菜甾醇)

Brassicasterol 是 Ergosterol 的一种代谢物，通过雄激素信号传导抑制膀胱癌的发生。Brassicasterol 对 HSV-1(IC50=1.2 µM) 和 结核分枝杆菌及心血管保护作用。 Brassicasterol 通过双重靶向 AKT 和雄激素受体信号通路在前列腺癌中发挥抗癌作用。

Brassicasterol(Synonyms: 油菜甾醇)

Brassicasterol Chemical Structure

CAS No. : 474-67-9

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生物活性

Brassicasterol, a metabolite of Ergosterol, plays a role in the inhibitory effect on bladder carcinogenesis promotion via androgen signaling[1]. Brassicasterol shows dual anti-infective properties against HSV-1 (IC50=1.2 µM) and Mycobacterium tuberculosis, and cardiovascular protective effect[2]. Brassicasterol exerts an anti-cancer effect by dual-targeting AKT and androgen receptor signaling in prostate cancer[3].

分子量

398.66

Formula

C28H46O
CAS 号

474-67-9
中文名称

油菜甾醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yasuharu Yazawa, et al. Inhibitory effect of ergosterol on bladder carcinogenesis is due to androgen signaling inhibition by brassicasterol, a metabolite of ergosterol. J Nat Med. 2020 Sep;74(4):680-688.

    [2]. Sherif T S Hassan. Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments. Biomedicines. 2020 May 24;8(5):132.

    [3]. Yinzhu Xu, et al. Brassicasterol from Edible Aquacultural Hippocampus abdominalis Exerts an Anti-Cancer Effect by Dual-Targeting AKT and AR Signaling in Prostate Cancer. Biomedicines. 2020 Sep 22;8(9):370.

5,6,7,4′-Tetrahydroxyflavonol 3-O-rutinoside(Synonyms: 6-Hydroxykaempferol 3-β-rutinoside)

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天然产物 糖类和糖苷 Saccharides and Glycosides

5,6,7,4′-Tetrahydroxyflavonol 3-O-rutinoside;(Synonyms: 6-Hydroxykaempferol 3-β-rutinoside)

5,6,7,4′-Tetrahydroxyflavonol 3-O-rutinoside 是具有抗氧化活性的天然糖苷。

5,6,7,4

5,6,7,4′-Tetrahydroxyflavonol 3-O-rutinoside Chemical Structure

CAS No. : 205527-00-0

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生物活性

5,6,7,4′-Tetrahydroxyflavonol 3-O-rutinoside is a natural antioxidant flavonoid glycoside[1].

分子量

610.52

Formula

C27H30O16
CAS 号

205527-00-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. E J Gamez, et al. Antioxidant flavonoid glycosides from Daphniphyllum calycinum. J Nat Prod. 1998 May;61(5):706-8.

Eupalinilide B(Synonyms: 林泽兰内酯B)

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Eupalinilide B (Synonyms: 林泽兰内酯B)

Eupalinilide B 是一种愈创木酚型倍半萜内酯，存在于 Eupatorium lindleyanum 中。Eupalinilide B 对 P-388 和 A-549 肿瘤细胞系显示出有效的细胞毒性。

Eupalinilide B(Synonyms: 林泽兰内酯B)

Eupalinilide B Chemical Structure

CAS No. : 757202-08-7

规格 价格 是否有货
1 mg ￥1900 询问价格 & 货期
5 mg ￥5710 询问价格 & 货期

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生物活性

Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines[1].

体外研究
(In Vitro)

Eupalinilide B (0.1-10 μM) shows potent cytotoxicity against A-549, BGC-823, SMMC-7721 and HL-60 tumour cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

360.40

Formula

C20H24O6
CAS 号

757202-08-7
中文名称

林泽兰内酯B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Huo J, et, al. Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum. J Nat Prod. 2004 Sep;67(9):1470-5.

Ganoderenic acid E(Synonyms: 灵芝烯酸 E)

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Ganoderenic acid E (Synonyms: 灵芝烯酸 E)

Ganoderenic acid E 是一种三萜类化合物。

Ganoderenic acid E(Synonyms: 灵芝烯酸 E)

Ganoderenic acid E Chemical Structure

CAS No. : 110241-23-1

规格 价格 是否有货
1 mg ￥3050 询问价格 & 货期
5 mg ￥9140 询问价格 & 货期

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生物活性

Ganoderenic acid E is a lanostane-type triterpene.

分子量

528.63

Formula

C30H40O8
CAS 号

110241-23-1
中文名称

灵芝烯酸 E
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Waltonitone(Synonyms: 长梗秦艽酮)

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Waltonitone (Synonyms: 长梗秦艽酮)

Waltonitone 是一种从植物天竺葵中提取的乌斯烷型五环三萜。Waltonitone 在体外和体内均显着抑制肝癌细胞的生长并诱导细胞凋亡。

Waltonitone(Synonyms: 长梗秦艽酮)

Waltonitone Chemical Structure

CAS No. : 1252676-55-3

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生物活性

Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo[1].

体外研究
(In Vitro)

waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells[1].
Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis[1].
Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

440.70

Formula

C30H48O2
CAS 号

1252676-55-3
中文名称

长梗秦艽酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Z, et al. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.Cancer Lett. 2009 Dec 28;286(2):223-31.

Neophytadiene(Synonyms: 新植二烯)

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Neophytadiene (Synonyms: 新植二烯)

Neophytadiene 是一种二萜，能从 Turbinaria ornate 中提取到，具有抗炎、抗氧化和心脏保护作用。

Neophytadiene(Synonyms: 新植二烯)

Neophytadiene Chemical Structure

CAS No. : 504-96-1

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生物活性

Neophytadiene is a diterpene found in Turbinaria ornate, with anti-inflammatory antioxidant and cardioprotective properties[1].

体外研究
(In Vitro)

Neophytadiene has cytotoxic on RAW 264.7 cells with an IC50 of 50 μM[1].
Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulates inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells[1].
Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Neophytadiene (50 mg/kg; p.o.; daily; for 7 days) shows dose-dependent reduction in the alanine aminotransferase (ALT) level[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased IL-6 and 1L-10 levels and in heart tissue[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased PGE2 mRNA expression in heart tissue[1].
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley rats (6-8 weeks)[1]
Dosage: 12 mg/kg, 25 mg/kg, 50 mg/kg
Administration: Oral administration, daily, for 7 days
Result: Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats.

分子量

278.52

Formula

C20H38
CAS 号

504-96-1
中文名称

新植二烯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Meenakshi Bhardwaj, et al. Neophytadiene from Turbinaria ornata Suppresses LPS-Induced Inflammatory Response in RAW 264.7 Macrophages and Sprague Dawley Rats. Inflammation. 2020 Jun;43(3):937-950.

Prosaikogenin D(Synonyms: 柴胡次皂苷D)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Prosaikogenin D;(Synonyms: 柴胡次皂苷D)

Prosaikogenin D 是从柴胡的根中分离出的，具有抗癌活性。

Prosaikogenin D(Synonyms: 柴胡次皂苷D)

Prosaikogenin D Chemical Structure

CAS No. : 103629-72-7

规格 价格 是否有货
1 mg ￥1600 询问价格 货期

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生物活性

Prosaikogenin D, isolated from the roots of Buleurum bicaule Helm (Apiaceae), has anti-cancer activity[1][2].

体外研究
(In Vitro)

Prosaikogenin D (20, 40, 60 μg/mL) suppresses the proliferation of A549 cells with an IC50 of 57.2 μg/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

618.84

Formula

C36H58O8
CAS 号

103629-72-7
中文名称

柴胡次皂苷D
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nan Xu, et al. A new saikogenin from the roots of Bupleurum bicaule. Chin J Nat Med. 2014 Apr;12(4):305-8.

    [2]. Lu Shi, et al. A Potential Anti-cancer Compound Separated from the Chloroform Extract of the Chinese Medicine Formula Shenqi San. Curr Med Sci. 2020 Feb;40(1):138-144.

Pam3CSK4(Synonyms: Pam3Cys-Ser-(Lys)4)

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Pam3CSK4;(Synonyms: Pam3Cys-Ser-(Lys)4)

Pam3CSK4 是一种 Toll 样受体 1/2 (TLR1/2) 激动剂，对人 TLR1/2 的 EC50 为 0.47 ng/mL。

Pam3CSK4amp;;(Synonyms: Pam3Cys-Ser-(Lys)4)

Pam3CSK4 Chemical Structure

CAS No. : 112208-00-1

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250 mg ; 询价 ;
500 mg ; 询价 ;

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Pam3CSK4 的其他形式现货产品:

Pam3CSK4 TFA

生物活性

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].

体外研究
(In Vitro)

Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides[1].
Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant Staphylococcus aureus[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2tm1Kir/J (TLR2 -deficient) mice[3]
Dosage: 5 mg/kg
Administration: Intraperitoneally (i.p.); once a day for 9 days
Result: After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12.

分子量

1510.23

Formula

C81H156N10O13S
CAS 号

112208-00-1
Sequence

{Pam3Cys}-Ser-Lys-Lys-Lys-Lys
Sequence Shortening

Pam3C-SKKKK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Irvine KL, et al. The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. Vet Res. 2013 Jul 4;44:50.

    [2]. Chen Y, et al. TLR2 agonist Pam3CSK4 enhances the antibacterial functions of GM-CSF induced neutrophils to methicillin-resistant Staphylococcus aureus. Microb Pathog. 2019 May;130:204-212.

    [3]. Du X, et al. Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One. 2011 May 6;6(5):e19583.