Apelin-17(human, bovine)

发表于由

Apelin-17(human, bovine); 纯度: 98.86%

Apelin-17(human, bovine) 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-17(human, bovine) 与在 HEK 293 细胞中表达的人 APJ 受体结合 (pIC50=9.02)。Apelin-17(human, bovine) 阻断 HIV-1 和 HIV-2 毒株进入表达 APJ 的 NP-2/CD4 细胞。

Apelin-17(human, bovine)amp;;

Apelin-17(human, bovine) Chemical Structure

CAS No. : 217082-57-0

规格 价格 是否有货 数量
1 mg ￥700 In-stock
5 mg ￥2100 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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Apelin-17(human, bovine) 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

IC50 Target[3]

HIV-1

;

HIV-2

;

分子量

2138.55

Formula

C96H156N34O20S
CAS 号

217082-57-0
Sequence

Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

KFRRQRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

    [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

    [3]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.