Osthenol(Synonyms: Ostenol)

天然产物 天然产物苯丙素类 Phenylpropanoids

Osthenol (Synonyms: Ostenol) 纯度: 98.91%

Osthenol (Ostenol) 是从独活干根中分离得到的一种前酰化香豆素,是一种可逆的,选择性的竞争性人单胺氧化酶-A (hMAO-A) 抑制剂 (Ki=0.26 µM)。Osthenol 对重组 hMAO-A 具有潜在的选择性抑制作用,IC50为 0.74 µM,对hMAO-A和hMAO-B表现出较高的选择性指数。

Osthenol(Synonyms: Ostenol)

Osthenol Chemical Structure

CAS No. : 484-14-0

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生物活性

Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1].

IC50 & Target[1]

hMAO-A

0.26 μM (Ki)

hMAO-A

0.74 μM (IC50)

分子量

230.26

Formula

C14H14O3

CAS 号

484-14-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843.

    [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003.