[1]. Yongfen Ma, et al. Anti-inflammatory Activities of Coumarins Isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 Cells. J Food Sci Nutr Vol 14, p 179~187 (2009).
(E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate), found in several plants, such as green onion (Allium cepa) or noni (Morinda citrifolia L.) leaves. (E)-Methyl 4-coumarate cooperates with Carnosic Acid in inducing apoptosis and killing acute myeloid leukemia cells, but not normal peripheral blood mononuclear cells. Antioxidant and antimicrobial activity.
分子量
178.18
Formula
C10H10O3
CAS 号
19367-38-5
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Trachtenberg A, et al. Synergistic Cytotoxicity of Methyl 4-Hydroxycinnamate and Carnosic Acid to Acute Myeloid Leukemia Cells via Calcium-Dependent Apoptosis Induction. Front Pharmacol. 2019 May 9;10:507.
[1]. Liu Jiasen, et al. STUDIES ON THE ACTIVE PRINCIPLES OF SCHISANDRA SPHENANTHERA REHD. ET WILS. THE STRUCTURES OF SCHISANTHERIN A, B, C, D, E, AND THE RELATED COMPOUNDS. Science China Mathematics, 1978, (4)
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3].
分子量
192.17
Formula
C10H8O4
CAS 号
2107-77-9
中文名称
4-甲基瑞香素
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21.
[2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74.
[3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4.
Salvianolic acid D 是从Salvia miltiorrhiza 中分离得到的,是潜在抗血小板活性的化合物。
Salvianolic acid D Chemical Structure
CAS No. : 142998-47-8
规格
价格
是否有货
数量
1 mg
¥2860
In-stock
5 mg
¥8570
In-stock
10 mg
询价
50 mg
询价
* Please select Quantity before adding items.
生物活性
Salvianolic acid D, isolated from Salvia miltiorrhiza, is a potential antiplatelet activity compound[1][2].
分子量
418.35
Formula
C20H18O10
CAS 号
142998-47-8
中文名称
丹酚酸 D
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
参考文献
[1]. Ai CB, et al. Salvianolic Acids D and E: Two New Depsides from Salvia miltiorrhiza. Planta Med. 1992 Apr;58(2):197-9.
[2]. Chen Y, et al. A Platelet/CMC coupled with offline UPLC-QTOF-MS/MS for screening antiplatelet activity components from aqueous extract of Danshen. J Pharm Biomed Anal. 2016 Jan 5;117:178-83.
[1]. Eva Tavčar Benković, et al. Identification, in vitro and in vivo Antioxidant Activity, and Gastrointestinal Stability of Lignans from Silver Fir (Abies alba) Wood Extract. Journal of Wood Chemistry and Technology. 2017 Jan, 467-477.
Magnolioside, isolated from Angelica gigas Nakai (Umbelliferae), exhibits significant neuroprotective activities against glutamate-induced toxicity[1].
分子量
354.31
Formula
C16H18O9
CAS 号
20186-29-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献
[1]. Kang SY, et al. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Arch Pharm Res. 2007 Nov;30(11):1368-73.
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献
[1]. Zhang XM, et al. Blocking effects of heteroclitin D and gomisin J on L-type calcium channels in ventricular cells of guinea pig. Acta Pharmacol Sin. 2000 Apr;21(4):373-6.
Dimethylfraxetin 是一种 Carbonic anhydrase 抑制剂,其 Ki 值为 0.0097 μM。
Dimethylfraxetin Chemical Structure
CAS No. : 6035-49-0
规格
价格
是否有货
数量
10 mM * 1 mL in DMSO
¥1430
In-stock
5 mg
¥1300
In-stock
10 mg
¥2300
In-stock
25 mg
¥4600
In-stock
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
Dimethylfraxetin 相关产品
•相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Natural Product Library
Anti-Cancer Compound Library
Traditional Chinese Medicine Monomer Library
Targeted Diversity Library
生物活性
Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM.
IC50 & Target
Ki: 0.0097 μM (Carbonic anhydrase)[1]
体外研究 (In Vitro)
At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
236.22
Formula
C12H12O5
CAS 号
6035-49-0
中文名称
二甲基白蜡树亭;白蜡树素;涔皮素
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 125 mg/mL (529.17 mM; Need ultrasonic and warming)
[1]. Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15;21(6):1539-43.
Kinase Assay [1]
Inhibitor (including Dimethylfraxetin) and enzyme solutions are preincubated together for 6 h at room temperature prior to assay, in order to allow for the formation of the enzyme-inhibitor complex[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15;21(6):1539-43.
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].
体外研究 (In Vitro)
Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
308.33
Formula
C16H20O6
CAS 号
483-90-9
中文名称
毛两面针素
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Yu B, et al. Inhibition of PAI-1 Activity by Toddalolactone as a Mechanism for Promoting Blood Circulation and Removing Stasis by Chinese Herb Zanthoxylum nitidum var. tomentosum. Front Pharmacol. 2017 Jul 21;8:489.