Myostatin-IN-1;
Myostatin-IN-1 是一种有效的肌肉生成抑制素 (myostatin) 抑制剂 (myostatin、GDF-11、activin A 和 TGF-β1 的IC50 分别为 0.19 μM、0.63 μM、0.89 μM 和 1.6 μM)。Myostatin-IN-1 能增加小鼠胫骨前肌质量。Myostatin-IN-1 可用于研究骨骼肌中肌生成抑制素的长期失活。
Myostatin-IN-1 Chemical Structure
CAS No. : 2757831-08-4
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| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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| 生物活性 |
Myostatin-IN-1 is a potent myostatin inhibitor (IC50 of 0.19, 0.63, 0.89 and 1.6 μM for myostatin, GDF-11, activin A and TGF-β1, respectively). Myostatin-IN-1 increases the tibialis anterior muscle mass in mice. Myostatin-IN-1 can be used for researching the prolonged inactivation of myostatin in skeletal muscle[1]. |
IC50 Target |
IC50: 0.19 μM (myostatin), 0.63 μM (GDF-11), 0.89 μM (activin A), 1.6 μM (TGF-β1)[1] |
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| 体外研究 (In Vitro) |
Myostatin-IN-1 (MID-35) (50 µM; 400 min) possesses complete proteolytic stability, and can survive 99 and 97% of the intact form incubated for 400 min in trypsin or α-chymotrypsin solution[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
Myostatin-IN-1 (0.75 mM; i.m.; single) can significantly induce the increase in tibialis anterior (TA) muscle mass in C57BL/6J mice[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
2350.94 |
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| Formula |
C118H184N34O17 |
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| CAS 号 |
2757831-08-4 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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