Neurokinin A(4-10)(Synonyms: 神经激肽 A (4-10))

Neurokinin A(4-10);(Synonyms: 神经激肽 A (4-10))

Neurokinin A (4-10) 是速激肽 NK2 受体激动剂。

Neurokinin A(4-10)amp;;(Synonyms: 神经激肽 A (4-10))

Neurokinin A(4-10) Chemical Structure

CAS No. : 97559-35-8

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
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Neurokinin A(4-10) 的其他形式现货产品:

Neurokinin A(4-10) TFA

生物活性

Neurokinin A (4-10) is a tachykinin NK2 receptor agonist.

IC50 Target

NK2 receptor[1]

体外研究
(In Vitro)

Neurokinin A (NKA) and its truncated form NKA(4-10) are potent spasmogens of human colon circular muscle, an action mediated exclusively via tachykinin NK2 receptors. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) is performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. A high density of NK2 receptors has been demonstrated in this tissue, using in vitro autoradiography and radioligand binding[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

766.91

Formula

C34H54N8O10S

CAS 号

97559-35-8

Sequence

Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

Sequence Shortening

DSFVGLM-NH2

中文名称

神经激肽 A (4-10)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Warner FJ, et al. Structure-activity relationship of neurokinin A(4-10) at the human tachykinin NK(2) receptor: the effect of amino acid substitutions on receptor affinity and function. Biochem Pharmacol. 2002 Jun 15;63(12):2181-6.