Pam3CSK4-Biotin(Synonyms: Pam3Cys-Ser-(Lys)4-Biotin)

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Pam3CSK4-Biotin;(Synonyms: Pam3Cys-Ser-(Lys)4-Biotin)

Pam3CSK4-Biotin 是生物素化的 Pam3CSK4。Pam3CSK4-Biotin 是 Toll 样受体 1/2 (TLR1/2) 激动剂。

Pam3CSK4-Biotinamp;;(Synonyms: Pam3Cys-Ser-(Lys)4-Biotin)

Pam3CSK4-Biotin Chemical Structure

规格 是否有货
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250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Pam3CSK4-Biotin is biotinylated Pam3CSK4. Pam3CSK4-Biotin is a Toll-like receptor 1/2 (TLR1/2) agonist[1].

IC50 Target

TLR1

;

TLR2

;

体外研究
(In Vitro)

Pam3CSK4-Biotin (100 ng/mL) induces NF-κB activation from endosomal compartments[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1962.85

Formula

C103H192N14O17S2
Sequence Shortening

Pam3C-SKKKK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Brandt KJ, et al. TLR2 ligands induce NF-κB activation from endosomal compartments of human monocytes. PLoS One. 2013 Dec 12;8(12):e80743.