Prion Protein 106-126 (human)(Synonyms: PrP 106-126 (human))

发表于由

Prion Protein 106-126 (human);(Synonyms: PrP 106-126 (human))

Prion Protein 106-126 (human) 是 Prion 的多肽片段，它可以诱导神经元凋亡，抗蛋白酶 K 消化，纤维形成，并介导正常细胞病毒蛋白 (PrPc) 转化为致病同工型 (PrPSc)。Prion Protein 106-126 (human) 通常用作研究朊病毒蛋白疾病中神经变性的模型。

Prion Protein 106-126 (human)amp;;(Synonyms: PrP 106-126 (human))

Prion Protein 106-126 (human) Chemical Structure

CAS No. : 148439-49-0

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生物活性

Prion Protein 106-126 (human), a peptide fragment of prion, and can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease[1][2].

分子量

1912.24

Formula

C80H138N26O24S2
CAS 号

148439-49-0
Sequence Shortening

KTNMKHMAGAAAAGAVVGGLG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Forloni G, et, al. Neurotoxicity of a prion protein fragment. Nature. 1993 Apr 8; 362(6420): 543-6.

    [2]. Hong JM, et, al. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Int J Biochem Cell Biol. 2020 Feb; 119: 105680.