分类目录归档：萜类及其苷类

天然产物萜类及其苷类

Leelamine hydrochloride(Synonyms: 脱氢松香胺盐酸盐)

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Leelamine hydrochloride (Synonyms: 脱氢松香胺盐酸盐)

Leelamine hydrochloride 是一种从松树皮中提取的三环二萜分子。Leelamine hydrochloride 是一种大麻素 1 型 (CB1) 激动剂，也是前列腺癌细胞中 SREBP1 调节的脂肪酸/脂质合成的抑制剂，不受雄激素受体状态的影响。Leelamine hydrochloride 抑制调节脂肪酸合成的雄激素受体 (androgen receptor) 的转录活性。

Leelamine hydrochloride(Synonyms: 脱氢松香胺盐酸盐)

Leelamine hydrochloride Chemical Structure

CAS No. : 16496-99-4

规格 是否有货
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25 mg 询价

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生物活性

Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

IC50 & Target[2]

CB1

 

分子量

321.93

Formula

C20H32ClN
CAS 号

16496-99-4
中文名称

脱氢松香胺盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kuzu OF, et al. Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

    [2]. A.O. Ibegbu, et al. Therapeutic Potentials and uses of Cannabinoid Agonists in Health and Disease Conditions. British Journal of Pharmacology and Toxicology 3(2): 76-88, 2012

    [3]. Singh KB, et al. Leelamine is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. Mol Cancer Ther. 2019 Aug 8.

Lucidenic acid B(Synonyms: 赤芝酸 B)

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Lucidenic acid B (Synonyms: 赤芝酸 B)

Lucidenic acid B 是从灵芝中分离得到的天然产物，可诱导肿瘤细胞凋亡，可产生 caspase-9 和 caspase-3 的活化和 PARP 的裂解。Lucidenic acid B 对细胞周期没有影响，且对坏死细胞无作用。

Lucidenic acid B(Synonyms: 赤芝酸 B)

Lucidenic acid B Chemical Structure

CAS No. : 95311-95-8

规格 价格 是否有货
1 mg ￥2860 询问价格 & 货期
5 mg ￥8570 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells[1].

IC50 & Target

Apoptosis[1]
分子量

474.59

Formula

C27H38O7
CAS 号

95311-95-8
中文名称

赤芝酸 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hsu CL, et al. Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway. J Agric Food Chem. 2008 Jun 11;56(11):3973-80.

Ginkgolide J(Synonyms: 银杏内酯J)

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Ginkgolide J (Synonyms: 银杏内酯J) 纯度: ≥98.0%

Ginkgolide J 是银杏叶中非黄酮部分的主要成分，IC50 的范围为 12-54 µM，具有神经保护和抗神经元凋亡的能力。

Ginkgolide J(Synonyms: 银杏内酯J)

Ginkgolide J Chemical Structure

CAS No. : 107438-79-9

规格 价格 是否有货 数量
5 mg ￥2690 In-stock
10 mg ￥4570 In-stock
50 mg   询价  
100 mg   询价  

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  • Covalent Screening Library Plus
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  • Natural Product Library
  • Covalent Screening Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Neuroprotective Compound Library
  • Food-Sourced Compound Library

生物活性

Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability[1][2].

体内研究
(In Vivo)

Ginkgolide J (100 μM) treatment reduces the apoptotic damage induced by serum deprivation (24h) or treatment with Staurosporine (200 nM, 24h) in cultured chick embryonic neurons[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

424.40

Formula

C20H24O10
CAS 号

107438-79-9
中文名称

银杏内酯J
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (589.07 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3563 mL 11.7813 mL 23.5627 mL
5 mM 0.4713 mL 2.3563 mL 4.7125 mL
10 mM 0.2356 mL 1.1781 mL 2.3563 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.90 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.90 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.90 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.90 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Ahlemeyer B, et al. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer’s disease. Pharmacopsychiatry. 2003 Jun; 36 Suppl 1:S8-14.

    [2]. Sylvia Pietri, et al. Synthesis and Biological Studies of a New Ginkgolide C Derivative: Evidence That the Cardioprotective Effect of Ginkgolides Is Unrelated to PAF Inhibition. DRUG DEVELOPMENT RESEARCH. 2001.54:191-201.

Ganoderic acid C1(Synonyms: 灵芝酸C1)

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Ganoderic acid C1 (Synonyms: 灵芝酸C1) 纯度: ≥95.0%

Ganoderic acid C1 是可从 G. lucidum 分离得到的天然产物，可抑制小鼠巨噬细胞TNF-α 的产生。

Ganoderic acid C1(Synonyms: 灵芝酸C1)

Ganoderic acid C1 Chemical Structure

CAS No. : 95311-97-0

规格 价格 是否有货 数量
1 mg ￥2800 In-stock
5 mg ￥7800 In-stock
10 mg   询价  
50 mg   询价  

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Ganoderic acid C1 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells)[1].

分子量

514.65

Formula

C30H42O7
CAS 号

95311-97-0
中文名称

灵芝酸C1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (97.15 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9431 mL 9.7153 mL 19.4307 mL
5 mM 0.3886 mL 1.9431 mL 3.8861 mL
10 mM 0.1943 mL 0.9715 mL 1.9431 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.43 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.43 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (2.43 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.43 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.43 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.43 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Changda Liu, et al. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. Int Immunopharmacol. 2015 Aug;27(2):224-31.

Rhodojaponin V(Synonyms: 闹羊花素 V)

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Rhodojaponin V (Synonyms: 闹羊花素 V) 纯度: ≥99.0%

Rhodojaponin V 是一种二萜类化合物，可从 Rhododendron molle 叶子中获得，具有抗炎活性。

Rhodojaponin V(Synonyms: 闹羊花素 V)

Rhodojaponin V Chemical Structure

CAS No. : 37720-86-8

规格 价格 是否有货 数量
1 mg ￥2290 In-stock
5 mg ￥6860 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Rhodojaponin V 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Rhodojaponin V is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity[1].

分子量

410.50

Formula

C22H34O7
CAS 号

37720-86-8
中文名称

闹羊花素 V
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (121.80 mM; Need ultrasonic)

H2O : 1 mg/mL (2.44 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4361 mL 12.1803 mL 24.3605 mL
5 mM 0.4872 mL 2.4361 mL 4.8721 mL
10 mM 0.2436 mL 1.2180 mL 2.4361 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.09 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.09 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.09 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Zhou J, et al. Anti-inflammatory Grayanane Diterpenoids from the Leaves of Rhododendron molle. J Nat Prod. 2018 Jan 26;81(1):151-161.

Kaji-ichigoside F1

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Kaji-ichigoside F1  纯度: ≥98.0%

Kaji-ichigoside F1 是从S. cuneata中分离得到的一种具有溶血性和体外抗病毒活性的化合物。

Kaji-ichigoside F1

Kaji-ichigoside F1 Chemical Structure

CAS No. : 95298-47-8

规格 价格 是否有货 数量
5 mg ￥4500 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

Kaji-ichigoside F1 is isolated from S. cuneata with hemolytic and in vitro antiviral activity.[1]

分子量

650.84

Formula

C36H58O10
CAS 号

95298-47-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Jun Chang, et al.Phenolic glycosides and ionone glycoside from the stem of Sargentodoxa cuneata,Phytochemistry,Phytochemistry. 2005 Dec;66(23):2752-8.

Ganoderic acid N(Synonyms: 灵芝酸 N)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Ganoderic acid N (Synonyms: 灵芝酸 N) 纯度: 99.81%

Ganoderic acid N 是可从真菌灵芝中分离得到的天然萜类。

Ganoderic acid N(Synonyms: 灵芝酸 N)

Ganoderic acid N Chemical Structure

CAS No. : 110241-19-5

规格 价格 是否有货 数量
5 mg ￥5000 In-stock
10 mg ￥8500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Ganoderic acid N 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Lipid Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Food-Sourced Compound Library

生物活性

Ganoderic acid N is a natural terpenoid isolated from the Fungus Ganoderma lucidum[1][2].

分子量

530.65

Formula

C30H42O8
CAS 号

110241-19-5
中文名称

灵芝酸 N
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (94.22 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8845 mL 9.4224 mL 18.8448 mL
5 mM 0.3769 mL 1.8845 mL 3.7690 mL
10 mM 0.1884 mL 0.9422 mL 1.8845 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.36 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.36 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (2.36 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.36 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.36 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.36 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Zhenhao Li, et al. Screening Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Molecular Networking Combined With in vivo Zebrafish Assays. Front Pharmacol. 2020 Mar 18;11:287.

    [2]. Baosong Chen, et al. Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and α-glucosidase. Fitoterapia. 2017 Jul;120:6-16.

Verbenone(Synonyms: 马鞭草酮; (-)-Verbenone)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Verbenone (Synonyms: 马鞭草酮; (-)-Verbenone) 纯度: 99.27%

Verbenone ((-)-Verbenone) 是一种天然的萜烯，存在于 Suregada zanzibariensis Verdc 的树叶中。Verbenone 具有抗聚集信息素，可中断树皮甲虫对其聚集信息素的吸引。

Verbenone(Synonyms: 马鞭草酮; (-)-Verbenone)

Verbenone Chemical Structure

CAS No. : 1196-01-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
1 g ￥500 In-stock
5 g   询价  
10 g   询价  

* Please select Quantity before adding items.

Verbenone 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved & Pharmacopeial Drug Library

生物活性

Verbenone ((-)-Verbenone) is a natural terpene in leaves of the tree, Suregada zanzibariensis Verdc[1]. Verbenone has anti-aggregation pheromone and interrupts the attraction of bark beetles to their aggregation pheromones[2].

分子量

150.22

Formula

C10H14O
CAS 号

1196-01-6
中文名称

马鞭草酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (665.69 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.6569 mL 33.2845 mL 66.5690 mL
5 mM 1.3314 mL 6.6569 mL 13.3138 mL
10 mM 0.6657 mL 3.3285 mL 6.6569 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (16.64 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (16.64 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (16.64 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Innocent E, et al. Constituents of the essential oil of Suregada zanzibariensis leaves are repellent to the mosquito, Anopheles gambiae s.s..J Insect Sci. 2010;10:57.

    [2]. Fettig CJ, et al. Responses of Dendroctonus brevicomis (Coleoptera: Curculionidae) in behavioral assays: implications to development of a semiochemical-based tool for tree protection.J Econ Entomol. 2012 Feb;105(1):149-60.

Nagilactone B(Synonyms: 竹柏内酯 B)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Nagilactone B (Synonyms: 竹柏内酯 B) 纯度: ≥98.0%

Nagilactone B 是一种肝 X 受体 (LXR) 激动剂。

Nagilactone B(Synonyms: 竹柏内酯 B)

Nagilactone B Chemical Structure

CAS No. : 19891-51-1

规格 价格 是否有货 数量
1 mg ￥5400 In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

生物活性

Nagilactone B is a liver X receptor (LXR) agonist.

IC50 & Target

LXR[1]
体外研究
(In Vitro)

RAW264.7 cells are co-incubated with oxLDL (20 μg/mL) and Nagilactone B (0.02, 0.1, and 0.5 μM) for 24 h. Oil Red O (ORO) staining reveals significant lipid accumulation and foam cell formation in RAW264.7 cells following oxLDL treatment. Nagilactone B (NLB) significantly ameliorates intracellular lipid accumulation. ORO positive areas are reduced by 30.05±7.49 (P<0.01), 47.25±5.39 (P<0.001), and 48.65±7.44% (P<0.001) in Nagilactone B (0.02, 0.1, and 0.5 μM)-treated groups, respectively. The effects of Nagilactone B are evaluated ton cholesterol efflux. Nagilactone B (0.02, 0.1, and 0.5 μM) markedly promotes cholesterol efflux to extracellular apolipoprotein A-I (apoA-I) and high density lipoprotein (HDL) with maximal 5.72- (P<0.05) and 2.34-fold (P<0.01), respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Nagilactone B (NLB) suppresses atherosclerosis in apoE-/- mice by inducing ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) mediated cholesterol efflux in macrophages. Male apoE-deficient mice on C57BL/6J background receive Nagilactone B (10 and 30 mg/kg) for 12 weeks. Compared with the model group, Nagilactone B treatment (10 and 30 mg/kg) significantly reduces en face lesions of total aorta areas. Six-week-old male apoE-/- mice on an HFD are randomized to receive Atorvastatin (10 mg/kg/day), Nagilactone B (10 and 30 mg/kg/day), or CMC-Na for 12 weeks. Mice on chow diet are administered CMC-Na as the normal diet control group. En face aortic lesion areas are evaluated with Sudan IV staining and lesion areas in the aortic sinus monitored via ORO staining. Atherosclerosis developes slowly in the normal diet group, whereas lesions in the HFD model group are significantly increased in en face aortas. Nagilactone B treatment (10 and 30 mg/kg/day) significantly reduces en face aortic lesions, compared with the HFD group by 54.96±10.06% (P<0.01), 71.50±15.37% (P<0.001) in both NLB (L) and NLB (H) groups. In particular, Nagilactone B markedly attenuates atherosclerotic plaque lesion areas in the aortic arch aorta, thoracic aorta, and abdominal aorta [P<0.01 in NLB (H) group][1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

364.39

Formula

C19H24O7
CAS 号

19891-51-1
中文名称

竹柏内酯 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Gui Y, et al. A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice. Cardiovasc Res. 2016 Oct;112(1):502-14.
Cell Assay
[1]

RAW264.7 cells are plated into 12-well plates at 3×105 cells per well. After 12 h, cells are co-incubated with oxLDL (20 μg/mL) with or without Nagilactone B (0.02, 0.1, 0.5 μM) in DMEM for 24 h. At the end of the treatment period, cells are washed twice with PBS, fixed with 4% paraformaldehyde, and stained by filtered 0.5% ORO. Images are obtained via DP70 microscopy from at least six randomly selected fields for each condition. Data are analysed with Image-Pro Plus 6.0 software. The ratio of foam cells is calculated as the percentage of stained to total cell area[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice[1]
ApoE-/- mice at 6 weeks of age on a C57BL/6J background are randomly divided into five groups [normal diet, model, Atorvastatin, NLB (L), and NLB (H) groups]. Atorvastatin and NLB are dissolved in CMC-Na before administered. Mice on the normal diet receive carboxymethylcellulose sodium (CMC-Na) as the negative control group. Mice on a high-fat diet (HFD) (0.15% cholesterol and 18% fat) are administered CMC-Na or Atorvastatin (10 mg/kg) or Nagilactone B [10 and 30 mg/kg, as NLB (L) and NLB (H), respectively] daily in an intragastric manner for 12 weeks. Body weight and food intake are monitored[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Gui Y, et al. A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice. Cardiovasc Res. 2016 Oct;112(1):502-14.

Spathulenol

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Spathulenol  纯度: ≥95.0%

Spathulenol 分离自 Psidium guineense Sw，具有抗氧化，抗炎，抗增殖和抗分枝杆菌活性。 Spathulenol 在 DPPH 系统中显示出高抗氧化活性，IC50 为 85.60 μg/mL。

Spathulenol

Spathulenol Chemical Structure

CAS No. : 6750-60-3

规格 价格 是否有货 数量
1 mg ￥3430 In-stock
5 mg ￥10290 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Spathulenol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Spathulenol is isolated from Psidium guineense Sw, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].

体外研究
(In Vitro)

Spathulenol exhibits a high antioxidant activity s in the DPPH and MDA system, exhibits significant DPPH free radical activity, with IC50 values of 85.60 μg/mL[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Spathulenol (oral administration; 300 mg/kg) shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model[1].
In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature and oxygenation conditions, PG-1 exhibits a high activity with an IC50 value of 26.13 μg/mL, respectively, which is comparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA, which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

220.35

Formula

C15H24O
CAS 号

6750-60-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Nascimento KF, et al. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol.J Ethnopharmacol. 2018 Jan 10;210:351-358.