分类目录归档：萜类及其苷类

天然产物萜类及其苷类

16-o-Acetyldarutigenol

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16-o-Acetyldarutigenol 

16-o-Acetyldarutigenol (compound 4) 是一种 ent-pimarane 二萜类化合物，从 Siegesbeckia orientalis 的乙醇提取物中分离出来。

16-o-Acetyldarutigenol

16-o-Acetyldarutigenol Chemical Structure

CAS No. : 1188282-01-0

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生物活性

16-o-Acetyldarutigenol (compound 4) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis[1].

分子量

364.52

Formula

C22H36O4
CAS 号

1188282-01-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang F, et al. ent-Pimarane diterpenoids from Siegesbeckia orientalis and structure revision of a related compound. J Nat Prod. 2009;72(11):2005-2008.

16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one

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16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one 

16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one (compound 9) 是从 Polyalthia longifolia var. pendula 的未成熟果实中分离出的二萜化合物。

16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one

16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one Chemical Structure

CAS No. : 165459-53-0

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生物活性

16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one (compound 9) is a diterpene compound isolated from the unripe fruits of Polyalthia longifolia var. pendula[1].

分子量

332.43

Formula

C20H28O4
CAS 号

165459-53-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yu ZX, et al. New clerodane diterpenoids from the roots of Polyalthia laui. Fitoterapia. 2016;111:36-41.

15,16-Di-O-acetyldarutoside

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15,16-Di-O-acetyldarutoside 

15,16-Di-O-acetyldarutoside (compound 5) 是一种 ent-pimarane 二萜化合物，从 Siegesbeckia orientalis 的乙醇提取物中分离出来。

15,16-Di-O-acetyldarutoside

15,16-Di-O-acetyldarutoside Chemical Structure

CAS No. : 1188282-02-1

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生物活性

15,16-Di-O-acetyldarutoside (compound 5) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis[1].

分子量

568.70

Formula

C30H48O10
CAS 号

1188282-02-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang F, et al. ent-Pimarane diterpenoids from Siegesbeckia orientalis and structure revision of a related compound. J Nat Prod. 2009;72(11):2005-2008.

Baccatin

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Baccatin 

Baccatin 是一种从 Sapium Sebiferum 的根中分离出来的化合物。

Baccatin

Baccatin Chemical Structure

CAS No. : 66107-60-6

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生物活性

Baccatin is a compound isolated from the roots of Sapium Sebiferum[1].

分子量

458.67

Formula

C29H46O4
CAS 号

66107-60-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li-Shian Shi, et al. A New Ent-Trachylobane Diterpenoid from the Roots of Sapium Sebiferum.

Daturadiol(Synonyms: 12-Oleanene-3,6-diol)

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Daturadiol (Synonyms: 12-Oleanene-3,6-diol)

Daturadiol (12-Oleanene-3,6-diol) 是一种三萜类化合物，对人类癌细胞系表现出中等的细胞毒活性。

Daturadiol(Synonyms: 12-Oleanene-3,6-diol)

Daturadiol Chemical Structure

CAS No. : 41498-79-7

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生物活性

Daturadiol (12-Oleanene-3,6-diol), a triterpenoid, displays moderate cytotoxic activity against human cancer cell lines[1].

分子量

442.72

Formula

C30H50O2
CAS 号

41498-79-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shuhei Yasumoto, et al. Functional Characterization of CYP716 Family P450 Enzymes in Triterpenoid Biosynthesis in Tomato. Front Plant Sci. 2017 Jan 30;8:21.

12-Demethyl neocaesalpin F

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12-Demethyl neocaesalpin F 

12-Demethyl neocaesalpin F 是一种二萜类化合物。

12-Demethyl neocaesalpin F

12-Demethyl neocaesalpin F Chemical Structure

CAS No. : 1228964-10-0

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生物活性

12-Demethyl neocaesalpin F is a diterpenoid compound[1].

分子量

470.55

Formula

C27H34O7
CAS 号

1228964-10-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Das B, et al. New diterpenoids from Caesalpinia species and their cytotoxic activity. Bioorg Med Chem Lett. 2010;20(9):2847-2850.

Ganoderenic acid H

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Ganoderenic acid H 

Ganoderenic acid H 是从 Ganoderma lucidum 中分离得到的化合物。

Ganoderenic acid H

Ganoderenic acid H Chemical Structure

CAS No. : 120462-48-8

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生物活性

Ganoderenic acid H is a compound isolated from the fruit bodies of Ganoderma lucidum[1].

分子量

512.63

Formula

C30H40O7
CAS 号

120462-48-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Guan SH, et al. Cytotoxic lanostanoid triterpenes from Ganoderma lucidum. J Asian Nat Prod Res. 2008;10(7-8):705-710.

Vitexolide E(Synonyms: 12-epi-Vitexolide D; Curcucomosin C)

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Vitexolide E (Synonyms: 12-epi-Vitexolide D; Curcucomosin C)

Vitexolide E 是一种从马来西亚种 Vitex vestita 的叶子中分离出来的二萜化合物。Vitexolide E 对 HCT-116 癌细胞系和人胎肺成纤维细胞 MRC5 细胞系具有细胞毒活性。

Vitexolide E(Synonyms: 12-epi-Vitexolide D; Curcucomosin C)

Vitexolide E Chemical Structure

CAS No. : 958885-86-4

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生物活性

Vitexolide E is a diterpenoid compound isolated from the leaves of the Malaysian species Vitex vestita. Vitexolide E shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line[1].

分子量

318.45

Formula

C20H30O3
CAS 号

958885-86-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Corlay N, et al. Antibacterial Labdane Diterpenoids from Vitex vestita. J Nat Prod. 2015;78(6):1348-1356.

Paclitaxel(Synonyms: 紫杉醇)

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Paclitaxel (Synonyms: 紫杉醇) 纯度: 99.96%

Paclitaxel 是一种天然抗肿瘤药，可稳定微管蛋白 (tubulin) 的聚合。Paclitaxel 可导致有丝分裂停滞和诱导细胞凋亡 (apoptosis)，最终导致细胞死亡。Paclitaxel 还可诱导细胞自噬 (autophagy)。

Paclitaxel(Synonyms: 紫杉醇)

Paclitaxel Chemical Structure

CAS No. : 33069-62-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥572 In-stock
10 mg ￥520 In-stock
50 mg ￥900 In-stock
100 mg ￥1500 In-stock
500 mg ￥5000 In-stock
1 g   询价  
5 g   询价  

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生物活性

Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Paclitaxel (20 nM; 48 hours) induces programmed cell death and exists a block at the G2/M phase of the cell cycle[1].
Paclitaxel (20 nM; 48 hours) induces a consistent increase in the level of p53[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: MCF-7, MDA-MB-231 cells
Concentration: 20 nM
Incubation Time: 48 hours
Result: Induced programmed cell death.

Cell Cycle Analysis[1]

Cell Line: MCF-7, MDA-MB-231 cells
Concentration: 20 nM
Incubation Time: 48 hours
Result: >60% of MCF-7 cells and 50% of MDA-MB-231 cells were in the G2/M phase following 24 h treament.

Western Blot Analysis[1]

Cell Line: MCF-7 cells (harboring wild-type p53)
Concentration: 20 nM
Incubation Time: 48 hours
Result: Induced a consistent increase in the level of p53.

体内研究
(In Vivo)

Paclitaxel (1-20 mg/kg; i.p.; 1 time/2 days for five cycles) obviously induces liver metastases at the low-Paclitaxel group with little influence on primary tumor growth[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MDA-231 xenograft-bearing mice[3]
Dosage: 1, 20 mg/kg
Administration: Intraperitoneal injection; five cycles (1 time/2 days)
Result: Liver metastases were obviously induced in the low-PTX (1 mg/kg) group with little influence on primary tumor growth compared with high-PTX group.

Clinical Trial

分子量

853.91

Formula

C47H51NO14
CAS 号

33069-62-4
中文名称

紫杉醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (117.11 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1711 mL 5.8554 mL 11.7108 mL
5 mM 0.2342 mL 1.1711 mL 2.3422 mL
10 mM 0.1171 mL 0.5855 mL 1.1711 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.44 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.44 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (2.44 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (2.44 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.44 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (2.44 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Choi YH, et al. Paclitaxel-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells. Oncol Rep. 2012 Dec;28(6):2163-9.

    [2]. Dziadyk JM, et al. Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest. Anticancer Res. 2004 Jan-Feb;24(1):27-36.

    [3]. Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Aug;283(15):2836-52.

    [4]. Pan Z, et al. Paclitaxel attenuates Bcl-2 resistance to apoptosis in breast cancer cells through an endoplasmic reticulum-mediated calciumrelease in a dosage dependent manner. Biochem Biophys Res Commun. 2013 Feb 13. pii: S0006-291X(13)00259-3.

    [5]. Cadamuro M, et al. Low dose paclitaxel reduces S100A4 nuclear import to inhibit invasion and hematogenous metastasis of cholangiocarcinoma. Cancer Res. 2016 Jun 21.

    [6]. Li Q, et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Jun 16.

    [7]. Yilmaz E, et al. Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy. Neuroscience. 2015 Aug 6;300:210-8.

    [8]. Jing C, et al. E7080 enhances the antitumor effects of paclitaxel in anaplastic thyroid cancer. Am J Cancer Res. 2017 Apr 1;7(4):903-912.

Cephalomannine(Synonyms: 三尖杉宁碱)

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Cephalomannine (Synonyms: 三尖杉宁碱) 纯度: 98.38%

Cephalomannine 是一种可以从大多数三尖杉属植物中分离得到的一种紫杉醇 (HY-B0015) 生物碱类似物。Cephalomannine 是一种具有口服活性的抗肿瘤试剂 (anti-tumor agent)，可作为化疗试剂用于癌症研究。

Cephalomannine(Synonyms: 三尖杉宁碱)

Cephalomannine Chemical Structure

CAS No. : 71610-00-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1820 In-stock
2 mg ￥834 In-stock
5 mg ￥1252 In-stock
10 mg ￥1989 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

Cephalomannine is a Paclitaxel (HY-B0015) alkaloidal analog and isolated from most Cephalotaxus species. Cephalomannine is an orally active anti-tumor agent and can be used as a chemotherapy agent for cancer research[1][2].

分子量

831.90

Formula

C45H53NO14
CAS 号

71610-00-9
中文名称

三尖杉宁碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (120.21 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2021 mL 6.0103 mL 12.0207 mL
5 mM 0.2404 mL 1.2021 mL 2.4041 mL
10 mM 0.1202 mL 0.6010 mL 1.2021 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.01 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.01 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Feng Gao, et al. Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel analogs from cephalomannine.Fitoterapia. 2013 Oct;90:79-84.

    [2]. Jianhua Li, et al. Microbial transformation of cephalomannine by Luteibacter sp. J Nat Prod. 2007 Dec;70(12):1846-9.