Decanoyl-RVKR-CMK TFA(Synonyms: DecRVKRcmk TFA)

发表于由

Decanoyl-RVKR-CMK TFA;(Synonyms: DecRVKRcmk TFA) 纯度: 96.40%

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA 抑制过表达的 gp160 加工和 HIV-1 的复制。

Decanoyl-RVKR-CMK TFAamp;;(Synonyms: DecRVKRcmk TFA)

Decanoyl-RVKR-CMK TFA Chemical Structure

CAS No. : 2098497-25-5

规格 价格 是否有货 数量
5 mg ￥6500 In-stock
10 mg ￥10500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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生物活性

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication[1].

体外研究
(In Vitro)

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1].
Decanoyl-RVKR-CMK (DecRVKRcmk) TFA blocks regulated secretion of VGF[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL
Concentration: 35 and 70 µΜ
Incubation Time: 7 days
Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).

分子量

858.43

Formula

C36H67ClF3N11O7
CAS 号

2098497-25-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 4 mg/mL (4.66 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1649 mL 5.8246 mL 11.6492 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84.

    [2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608.