Glucosamine sulfate(Synonyms: 硫酸氨基葡萄糖; D-Glucosamine sulfate)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Glucosamine sulfate;(Synonyms: 硫酸氨基葡萄糖; D-Glucosamine sulfate) 纯度: ge;98.0%

Glucosamine sulfate (D-Glucosamine sulfate) 是一种氨基糖, 是糖基化蛋白和脂质生化合成的突出前体, 用作膳食补充剂。Glucosamine sulfate 也是软骨基质和滑液中糖胺聚糖的天然成分，当外用时，对骨关节炎软骨和软骨细胞具有药理作用。

Glucosamine sulfate(Synonyms: 硫酸氨基葡萄糖; D-Glucosamine sulfate)

Glucosamine sulfate Chemical Structure

CAS No. : 29031-19-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
500 mg ￥500 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

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Glucosamine sulfate 相关产品

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生物活性

Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

IC50 Target[1]

Human Endogenous Metabolite

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体外研究
(In Vitro)

Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity[2].
Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3].
Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

277.25

Formula

C6H15NO9S
CAS 号

29031-19-4
中文名称

硫酸氨基葡萄糖；氨基葡萄糖硫酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 125 mg/mL (450.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6069 mL 18.0343 mL 36.0685 mL
5 mM 0.7214 mL 3.6069 mL 7.2137 mL
10 mM 0.3607 mL 1.8034 mL 3.6069 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7.

    [2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.

    [3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.

    [4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.