1,2-Dihydrotanshinone(Synonyms: 1,2-Dihydrotanshinquinone)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

1,2-Dihydrotanshinone (Synonyms: 1,2-Dihydrotanshinquinone)

1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) 是一种松香烷二萜。1,2-Dihydrotanshinone 抑制 (CUG) n-RNA 和剪接因子 muscleblind-like 1 之间形成的致病复合物的形成。1,2-Dihydrotanshinone 可用于强直性肌营养不良 1 型的研究。

1,2-Dihydrotanshinone(Synonyms: 1,2-Dihydrotanshinquinone)

1,2-Dihydrotanshinone Chemical Structure

CAS No. : 77769-21-2

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生物活性

1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].

体外研究
(In Vitro)

1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1) (≥50% inhibition at 100 µg/mL)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

278.30

Formula

C18H14O3

CAS 号

77769-21-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Faleschini MT, et, al. Discovery of natural products potentially active against myotonic dystrophy type 1. Planta Med 2015; 81-YRW_03.

    [2]. Fronza M, et, al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011 Aug 15;19(16):4876-81.