NoxA1ds

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NoxA1ds; 纯度: 98.82%

NoxA1ds 是一种高效选择性 Nox1 (NADPH oxidase isoform 1) 抑制剂。NoxA1ds 为氧化酶激活所需的 Nox1-NOXA1 结合建立了一个关键的相互作用位点。NoxA1ds 可用于高血压、动脉粥样硬化和肿瘤的研究。

NoxA1dsamp;;

NoxA1ds Chemical Structure

CAS No. : 1435893-78-9

规格 价格 是否有货 数量
1 mg ￥1200 In-stock
5 mg ￥3000 In-stock
10 mg ￥4800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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生物活性

NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia[1].

IC50 Target

Nox1[1]
分子量

1125.33

Formula

C50H88N14O15
CAS 号

1435893-78-9
Sequence Shortening

EPVDALGKAKV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (88.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8886 mL 4.4431 mL 8.8863 mL
5 mM 0.1777 mL 0.8886 mL 1.7773 mL
10 mM 0.0889 mL 0.4443 mL 0.8886 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ranayhossaini DJ, et al. Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J Biol Chem. 2013;288(51):36437-36450.