SL 0101-1(Synonyms: SL0101)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

SL 0101-1;(Synonyms: SL0101)

SL 0101-1 (SL0101) 是从热带植物F. refracta 中提取得到的山萘酚糖苷，是能穿透细胞的、选择性的、可逆的、ATP竞争性的 p90核糖体S6激酶(RSK) 的抑制剂，其IC50 值为 89 nM。SL 0101-1 (SL0101) 是选择性的 RSK1/2 抑制剂，其 Ki 值为 1 μM。

SL 0101-1(Synonyms: SL0101)

SL 0101-1 Chemical Structure

CAS No. : 77307-50-7

规格 价格 是否有货 数量
1 mg ￥1900 In-stock
5 mg ￥5900 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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生物活性

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM[2].

IC50 Target

IC50: 89 nM (RSK)[1].
Ki: 1 μM (RSK1/2)[2].
体外研究
(In Vitro)

SL 0101-1 (SL0101) shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

516.45

Formula

C25H24O12
CAS 号

77307-50-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.

    [2]. Yu Li, et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4′-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060.