DODAP hydrochloride

生化分析试剂 Biochemical Assay Reagents
DODAP hydrochloride;

DODAP (hydrochloride) 是一种可离子化的脂质。DODAP (hydrochloride) 具有研究基因传递的潜力。

DODAP hydrochloride

DODAP hydrochloride Chemical Structure

CAS No. : 329009-00-9

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生物活性

DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery[1].

分子量

684.52

Formula

C41H78ClNO4

CAS 号

329009-00-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kimura S, et al. Novel lipid combination for delivery of plasmid DNA to immune cells in the spleen. J Control Release. 2021;330:753-764.

Delcasertib hydrochloride(Synonyms: KAI-9803 hydrochloride BMS-875944 hydrochloride)

Delcasertib hydrochloride (Synonyms: KAI-9803 hydrochloride; BMS-875944 hydrochloride) 纯度: 98.11%

Delcasertib (KAI-9803) hydrochloride 是有效,选择性的 δ 蛋白激酶C (δPKC) 抑制剂。Delcasertib (KAI-9803) hydrochloride 可改善急性心肌梗死动物模型的缺血再灌注损伤。

Delcasertib hydrochloride (Synonyms: KAI-9803 hydrochloride; BMS-875944 hydrochloride)

Delcasertib hydrochloride Chemical Structure

规格 价格 是否有货 数量
5 mg ¥6500 In-stock
10 mg ¥9900 In-stock
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Delcasertib hydrochloride 相关产品

相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Delcasertib (KAI-9803) hydrochloride is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) hydrochloride could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI)[1][2].

IC50 & Target[1]

δPKC

 

体外研究
(In Vitro)

Delcasertib (KAI-9803) is composed of a selective δ-protein kinase C (δPKC) inhibitor peptide derived from the δV1-1 portion of δPKC (termed “cargo peptide”), conjugated reversibly to the cell-penetrating peptide 11-amino acid, arginine-rich sequence of the HIV type 1 transactivator protein (TAT47–57; termed “carrier peptide”) via a disulfide bond[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Delcasertib (KAI-9803, a single intraperitoneal injection) in mice results in the selective inhibition of PKC translocation in the liver, kidney, lung, heart, and brain[1].
Delcasertib (KAI-9803) administration at the end of ischemia has been found to reduce cardiac damage caused by ischemia-reperfusion in a rat model of acute myocardial infarction[1].
Delcasertib (KAI-9803) has been studied for the prevention of reperfusion injury in patients undergoing angioplasty after acute myocardial infarction[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male Crl:CD(SD) rats[1]
Dosage: 1 mg/kg (Pharmacokinetic Analysis).
Administration: Via the femoral vein.
Result: The distribution to tissues such as the liver, kidney, and heart is facilitated by the reversible conjugation to TAT47-57.

Clinical Trial

分子量

2916.74

Formula

C120H200ClN45O34S2

Sequence Shortening

Sequence 1:CYGRKKRRQRRR;Sequence 1′:CSFNSYELGSL (Disulfide bridge:Cys1-Cys1’)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 100 mg/mL (34.28 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3428 mL 1.7142 mL 3.4285 mL
5 mM 0.0686 mL 0.3428 mL 0.6857 mL
10 mM 0.0343 mL 0.1714 mL 0.3428 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Miyaji Y, et al. Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab Dispos. 2011 Oct;39(10):1946-53.

    [2]. Bates E, et al. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation. 2008 Feb 19;117(7):886-96.

  • [1]. Miyaji Y, et al. Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab Dispos. 2011 Oct;39(10):1946-53.

    [2]. Bates E, et al. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation. 2008 Feb 19;117(7):886-96.

BMSpep-57 hydrochloride

BMSpep-57 hydrochloride; 纯度: 99.79%

BMSpep-57 hydrochloride 是一种有效的大环肽类抑制剂,抑制 PD-1/PD-L1 相互作用,IC50 为 7.68 nM。BMSpep-57 hydrochloride 与 PD-L1 结合,MST 和 SPR 测定表明,Kd 分别为 19 nM 和 19.88 nM。BMSpep-57 hydrochloride 通过增加 PBMC 中 IL-2 的产生促进 T 细胞功能。

BMSpep-57 hydrochlorideamp;;

BMSpep-57 hydrochloride Chemical Structure

规格 价格 是否有货 数量
1 mg ¥8000 In-stock
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BMSpep-57 hydrochloride 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Macrocyclic Compound Library
  • Peptide Library

生物活性

BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs[1].

IC50 Target

IC50: 7.68 nM (PD-1/PD-L1 interaction)[1]

体外研究
(In Vitro)

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300 nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50 of 7.68 nM[1].
BMSpep-57 induced high levels of IL-2 at 1 µM and 500 nM concentrations in SEB-stimulated peripheral blood mononuclear cells[1].
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1904.63

Formula

C89H127ClN24O19S

Sequence

{mercaptoacetic acid}-Phe-Ala-Asn-Pro-His-Leu-Ser-Trp-Ser-Trp-{norleucine}-{norleucine}-Arg-Cys-Gly (Sulfide bridge:mercaptoacetic acid 1-Cys15)

Sequence Shortening

{mercaptoacetic acid}-FANPHLSWSW-{norleucine}-{norleucine}-RCG (Sulfide bridge:mercaptoacetic acid 1-Cys15)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Aravindhan Ganesan, et al. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.Sci Rep . 2019 Aug 27;9(1):12392.

2-Iminothiolane hydrochloride

生化分析试剂 Biochemical Assay Reagents
2-Iminothiolane hydrochloride;

2-Iminothiolane hydrochloride 是一种化学试剂,用于将巯基引入衍生自天冬酰胺连接聚糖的寡糖中。

2-Iminothiolane hydrochloride

2-Iminothiolane hydrochloride Chemical Structure

CAS No. : 4781-83-3

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100 mg ; 询价 ;
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2-Iminothiolane hydrochloride 相关产品

bull;相关化合物库:

  • Fragment Library

生物活性

2-Iminothiolane hydrochloride is a reagent for the introduction of sulphydryl groups into oligosaccharides derived from asparagine-linked glycans[1].

分子量

137.63

Formula

C4H8ClNS

CAS 号

4781-83-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. A L Tarentino, et al. 2-Iminothiolane: a reagent for the introduction of sulphydryl groups into oligosaccharides derived from asparagine-linked glycans. Glycobiology. 1993 Jun;3(3):279-85.

Hampton HR2-801 TCEP hydrochloride 10 g

上海金畔生物科技有限公司提供Hampton HR2-801 TCEP hydrochloride 10 g,欢迎访问官网了解更多产品信息和订购

品牌 货号 产品名称 规格 价格

Hampton HR2-801 TCEP hydrochloride 10 g 2100.00

Hampton HR2-741 50% v/v Pentaerythritol propoxylate (17/8 PO/OH) 200 ml 920.00

Hampton HR2-310 Silica Hydrogel™ 500 µl 1580.00

Hampton HR3-125 3 Well Midi Crystallization Plate in UVP (Swissci) 40/cs 5302.00

Hampton HR3-104 MRC Under Oil Crystallization Plate 40/cs 5302.00

Hampton HR3-180 MRC Maxi 48-Well Crystallization Plate (40) 40/cs 5302.00

Hampton HR3-107 MRC 2 Well Crystallization Plate in UVXPO (Swissci) 40/cs 5302.00

Hampton HR3-083 MRC 2 Well Crystallization Plate 40/cs 5302.00

Hampton HR3-194 3 Well Midi Crystallization Plate in UVXPO (Swissci) 40/cs 5302.00

Hampton HR3-206 3 Well Low Profile Crystallization Plate (Swissci) 40/cs 5302.00

Hampton HR2-070-88 Slice pH reagent 88 (H4) 185 ml 3030.00

Hampton HR2-070-87 Slice pH reagent 87 (H3) 185 ml 3030.00

Hampton HR2-070-86 Slice pH reagent 86 (H2) 185 ml 3030.00

Hampton HR2-070-85 Slice pH reagent 85 (H1) 185 ml 3030.00

Hampton HR2-070-52 Slice pH reagent 52 (E4) 185 ml 3030.00

Hampton HR2-070-51 Slice pH reagent 51 (E3) 185 ml 3030.00

Hampton HR2-070-50 Slice pH reagent 50 (E2) 185 ml 3030.00

Hampton HR2-070-49 Slice pH reagent 49 (E1) 185 ml 3030.00

Hampton HR2-659 10.0 M Ammonium formate 200 ml 2240.00

Hampton HR2-937-21 StockOptions™ Tris HCl #21 pH 9.0 185 ml 2240.00

AZD-7762 hydrochloride AZD-7766 盐酸盐 品牌:SynKinase


AZD-7762 hydrochloride

AZD-7766 盐酸盐

品牌:SynKinase
CAS No.:1246094-78-9
储存条件:-20°C
纯度:>95%
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

SYN-1017-M100

100 mg 咨询


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BIM-23190 hydrochloride

BIM-23190 hydrochloride; 纯度: 98.82%

BIM-23190 hydrochloride 是 somatostatin 的类似物,是 SSTR2 和SSTR5 的选择性激动剂,对SSTR2 和SSTR5 的Ki 值分别为 0.34 nM 和 11.1 nM。BIM-23190 可用于糖尿病和癌症研究。

BIM-23190 hydrochlorideamp;;

BIM-23190 hydrochloride Chemical Structure

规格 价格 是否有货 数量
5 mg ¥3500 In-stock
10 mg ¥5800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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BIM-23190 hydrochloride 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library
  • Macrocyclic Compound Library
  • Targeted Diversity Library
  • Peptide Library

生物活性

BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits Ki values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly[1][3].

体外研究
(In Vitro)

BIM-23190 tends to mildly stimulate PRL secretion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

BIM-23190 (50 μg/mouse, twice a day) exhibits significant anti-tumor (C6 glioma) activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude (nu/nu) mice, 5-6 wk old (C6 glioma)[2].
Dosage: 50 μg/mouse.
Administration: Injected twice a day for 19 days.
Result: Significantly reduced the tumor growth rate.

分子量

1238.91

Formula

C57H80ClN13O12S2

Sequence

{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-Cys-Tyr-{D-Trp}-Lys-{Abu}-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-CY-{D-Trp}-K-{Abu}-CT-NH2 (Disulfide bridge: Cys2-Cys7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (80.72 mM; Need ultrasonic)

H2O : 100 mg/mL (80.72 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8072 mL 4.0358 mL 8.0716 mL
5 mM 0.1614 mL 0.8072 mL 1.6143 mL
10 mM 0.0807 mL 0.4036 mL 0.8072 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.02 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.02 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (2.02 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92.

    [2]. Federica Barbieri, et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1078-88.

    [3]. T J Gillespie, et al. Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J Pharmacol Exp Ther. 1998 Apr;285(1):95-104.

Procaterol Hydrochloride Hemihydrate 丙卡特罗 品牌:FUJIFILM Wako


Procaterol Hydrochloride Hemihydrate

丙卡特罗

品牌:FUJIFILM Wako
CAS No.:62929-91-3
储存条件:2-10℃
纯度:98.0+% (HPLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

166-19863

for Biochemistry 50mg 3,000.00


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AP-III-a4 hydrochloride AP-III-a4盐酸盐 品牌:Adipogen


AP-III-a4 hydrochloride

AP-III-a4盐酸盐

品牌:Adipogen
CAS No.:1177827-73-4 (free base)
储存条件:-20°C
纯度:>95% (HPLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

AG-CR1-3696-M001

1 mg 780.00


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Acridine Orange hydrochloride hydrate 吖啶橙盐酸盐水合物 品牌:Chemodex


Acridine Orange hydrochloride hydrate

吖啶橙盐酸盐水合物

品牌:Chemodex
CAS No.:65-61-2 | 1704465-79-1
储存条件:+4°C
纯度:≥98% (HPLC)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

CDX-A0005-G001

1 g 900.00


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* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。