Mambalgin 1

发表于由

Mambalgin 1;

Mambalgin-1 是从黑曼巴蛇毒液中分离出来的毒素。Mambalgin-1 是一种富含二硫的多肽，由 57 个氨基酸组成，属于三指毒素家族。Mambalgin-1 可以结合并稳定 ASICs (acid-sensing ion channels)，形成生理上相关的闭通道构象。

Mambalgin 1amp;;

Mambalgin 1 Chemical Structure

CAS No. : 1609937-15-6

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation[1].

分子量

7283.22

Formula

C310H481N87O100S8
CAS 号

1609937-15-6
Sequence Shortening

LKCYQHGKVVTCHRDMKFCYHNTGMPFRNLKLILQGCSSSCSETENNKCCSTDRCNK (Disulfide bridge:Cys3-Cys19;Cys12-Cys37;Cys41-Cys49;Cys50-Cys55)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun D, et al. Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect. Cell Discov. 2018;4:27. Published 2018 Jun 5.