D-Hexamannuronic acid(Synonyms: D-甘露糖醛酸六糖)

天然产物 糖类和糖苷 Saccharides and Glycosides

D-Hexamannuronic acid;(Synonyms: D-甘露糖醛酸六糖)

D-Hexamannuronic acid 是一种藻酸盐低聚物,是由海洋褐藻和某些革兰氏阴性细菌产生的。D-Hexamannuronic acid 可用于疼痛和血管性痴呆的研究。

D-Hexamannuronic acid(Synonyms: D-甘露糖醛酸六糖)

D-Hexamannuronic acid Chemical Structure

CAS No. : 183668-52-2

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生物活性

D-Hexamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Hexamannuronic acid can be used for the research of pain and vascular dementia[1][2][3][4].

分子量

1074.76

Formula

C36H50O37

CAS 号

183668-52-2

中文名称

D-甘露糖醛酸六糖

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Heyraud A, et, al. HPLC analysis of saturated or unsaturated oligoguluronates and oligomannuronates. Application to the determination of the action pattern of Haliotis tuberculata alginate lyase. Carbohydr Res. 1996 Sep 23; 291:115-26.

    [2]. Iwamoto M, et, al. Structure-activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cells. FEBS Lett. 2005 Aug 15; 579(20): 4423-9.

    [3]. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of pain. CN106344595A.

    [4]. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of vascular dementia. CN106344593A.

L-octaguluronic acid octasodium salt(Synonyms: L-古罗糖醛酸八糖)

天然产物 糖类和糖苷 Saccharides and Glycosides

L-octaguluronic acid octasodium salt;(Synonyms: L-古罗糖醛酸八糖)

L-octaguluronic acid octasodium salt 是从海藻中提取的,它是天然生物聚合物藻酸盐的成分。

L-octaguluronic acid octasodium salt(Synonyms: L-古罗糖醛酸八糖)

L-octaguluronic acid octasodium salt Chemical Structure

CAS No. : 862694-88-0

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生物活性

L-octaguluronic acid octasodium salt is extracted from seaweed. L-octaguluronic acid octasodium salt is the component of the natural biopolymers, alginates[1][2].

分子量

1602.86

Formula

C48H58Na8O49

CAS 号

862694-88-0

中文名称

L-古罗糖醛酸八糖

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Iwamoto M, et, al. Structure-activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cells. FEBS Lett. 2005 Aug 15; 579(20): 4423-9.

    [2]. Plazinski W, et, al. Conformational properties of acidic oligo- and disaccharides and their ability to bind calcium: a molecular modeling study. Carbohydr Res. 2012 Aug 1; 357:111-7.

Bryonolic acid(Synonyms: 泻根醇酸)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Bryonolic acid (Synonyms: 泻根醇酸)

Bryonolic acid 是一种活性三萜化合物,具有免疫调节、抗炎,抗氧化和抗癌等活性。

Bryonolic acid(Synonyms: 泻根醇酸)

Bryonolic acid Chemical Structure

CAS No. : 24480-45-3

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5 mg ¥8000 询问价格 & 货期

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生物活性

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities[1][2][3].

体外研究
(In Vitro)

Bryonolic acid exerts anti-allergic activity by inhibiting homologous passive cutaneous anaphylaxis and delayed hypersensitivity. Bryonolic acid reduces nitric oxide by suppressing inducible nitric oxide synthase expression, indicating anti-inflammatory activity[1].
In rat adrenal pheochromocytoma (PC12) cells, Bryonolic acid against N-methyl-D-aspartate (NMDA)-induced neurotoxicity, indicating it as a candidate neuroprotective agent for cerebral ischemic treatment[1].
Bryonolic acid (1-200 μM) inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in rat liver microsomes in a concentration-dependent manner, blocking the biosynthesis of the cholesterol fatty acid ester tumour promoter. Bryonolic acid inhibits ACAT in intact cancer cells with an IC50 of 12.6 µM[2].
Bryonolic acid inhibits both clonogenicity and invasiveness in MCF-7 MB-231, U87 and 3T3-EA cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Bryonolic acid (500 mg/kg; i.p.; once) potently induces HO-1 in a manner dependent on the Nrf2-Keap1 pathway[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type and Nrf2-/- mice[3]
Dosage: 500 mg/kg
Administration: i.p.; once
Result: Induced HO-1 in a manner dependent on the Nrf2-Keap1 pathway.

分子量

456.70

Formula

C30H48O3

CAS 号

24480-45-3

中文名称

泻根醇酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pornpatsorn Lertphadungkit, et al. Enhanced Production of Bryonolic Acid in Trichosanthes cucumerina L. (Thai Cultivar) Cell Cultures by Elicitors and Their Biological Activities. Plants (Basel). 2020 Jun 2;9(6):709.

    [2]. Farid Khallouki, et al. Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation. Biomedicines. 2018 Feb 12;6(1):21.

    [3]. Tonibelle N Gatbonton-Schwager , et al. Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo. J Nat Prod. 2012 Apr 27;75(4):591-8.

Ursolic acid acetate(Synonyms: 熊果酸乙酸酯; Acetylursolic acid; 3-Acetylursolic acid)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Ursolic acid acetate (Synonyms: 熊果酸乙酸酯; Acetylursolic acid; 3-Acetylursolic acid) 纯度: ≥98.0%

Ursolic acid acetate (Acetylursolic acid),分离于Ficus microcarpa 的气根中,对 KB 细胞显示细胞毒性,IC50 值为 8.4 μM。

Ursolic acid acetate(Synonyms: 熊果酸乙酸酯; Acetylursolic acid;  3-Acetylursolic acid)

Ursolic acid acetate Chemical Structure

CAS No. : 7372-30-7

规格 价格 是否有货 数量
5 mg ¥1980 In-stock
10 mg ¥3360 In-stock
20 mg ¥5710 In-stock
50 mg   询价  
100 mg   询价  

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Ursolic acid acetate 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Monomer Library
  • Food-Sourced Compound Library

生物活性

Ursolic acid acetate (Acetylursolic acid), isolated from the aerial roots of Ficus microcarpa, exhibits cytotoxicity against KB cells with IC50 of 8.4 μM[1].

分子量

498.74

Formula

C32H50O4

CAS 号

7372-30-7

中文名称

熊果酸乙酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 25 mg/mL (50.13 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0051 mL 10.0253 mL 20.0505 mL
5 mM 0.4010 mL 2.0051 mL 4.0101 mL
10 mM 0.2005 mL 1.0025 mL 2.0051 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.51 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.51 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.51 mM); Clear solution

    此方案可获得 ≥ 1.25 mg/mL (2.51 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Chiang YM, et al. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry. 2005 Feb;66(4):495-501.

Coronalolic acid(Synonyms: Coronalonic acid)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Coronalolic acid (Synonyms: Coronalonic acid)

Coronalolic acid 是 Garden 子叶顶芽提取出来的,可以抑制 TNF-α 诱导的 NF-κB 活性和 NO 产生。

Coronalolic acid(Synonyms: Coronalonic acid)

Coronalolic acid Chemical Structure

CAS No. : 268214-52-4

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生物活性

Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production[1].

IC50 & Target[1]

NF-κB

 

体外研究
(In Vitro)

Coronalolic acid has an inhibition effect against the TNF-α-induced NF-κB activity and NO production with IC50s of 15.4 μM and 15.0 μM in LPS-stimulated RAW 264.7 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

470.68

Formula

C30H46O4

CAS 号

268214-52-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Youn UJ, et al. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis. Fitoterapia. 2016 Oct;114:92-97.

Siraitic Acid B(Synonyms: 罗汉果酸乙)

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Siraitic Acid B (Synonyms: 罗汉果酸乙)

Siraitic Acid B 是从罗汉果根中分离出的一种葫芦烷三萜。

Siraitic Acid B(Synonyms: 罗汉果酸乙)

Siraitic Acid B Chemical Structure

CAS No. : 183374-16-5

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5 mg ¥14290 询问价格 & 货期

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生物活性

Siraitic Acid B is a cucurbitane triterpenoid isolated from the root of S. grosvenori [1].

分子量

470.64

Formula

C29H42O5

CAS 号

183374-16-5

中文名称

罗汉果酸乙

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Asperulosidic Acid(Synonyms: 车叶草苷酸)

天然产物 糖类和糖苷 Saccharides and Glycosides

Asperulosidic Acid;(Synonyms: 车叶草苷酸)

Asperulosidic Acid (ASPA) 车叶草苷酸是一种具有生物活性的环烯醚萜苷,从白花蛇舌草 (Hedyotis diffusa Willd) 的草药中提取的。 Asperulosidic Acid (ASPA) 具有抗肿瘤,抗氧化和抗炎作用。 Asperulosidic Acid (ASPA) 通过抑制 NF-κB 和丝裂原活化蛋白激酶 (MAPK) 信号通路抑制炎性细胞因子(TNF-α,IL-6) 释放发挥抗炎作用。

Asperulosidic Acid(Synonyms: 车叶草苷酸)

Asperulosidic Acid Chemical Structure

CAS No. : 25368-11-0

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5 mg ¥4030 询问价格 货期
10 mg ¥6860 询问价格 货期

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生物活性

Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities[1]. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways[2].

体外研究
(In Vitro)

Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) significantly down-regulates the mRNA levels of TNF-α and IL-6 in LPS-induced RAW 264.7 cells compared with the group treated with LPS alone [1].
Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) decreases IκB-α phosphorylation in a concentration-dependent manner, decreases Erk1/2 phosphorylation at all concentration levels, but there was no effect on p-p38 [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: RAW 264.7 cells
Concentration: 40 μg/mL, 80 μg/mL, and 160 μg/mL
Incubation Time: Pre-treatment 1 hour
Result: Decreased TNF-α and IL-6 mRNA expression.

Western Blot Analysis[2]

Cell Line: RAW 264.7 cells
Concentration: 40 μg/mL, 80 μg/mL, and 160 μg/mL
Incubation Time: Pre-treatment 1 hour
Result: Decreased IκB-α phosphorylation and Erk1/2 phosphorylation.

分子量

432.38

Formula

C18H24O12

CAS 号

25368-11-0

中文名称

车叶草苷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xianyuan L , et al. Anti-renal fibrosis effect of asperulosidic acid via TGF-β1/smad2/smad3 and NF-κB signaling pathways in a rat model of unilateral ureteral obstruction. Phytomedicine. 2019 Feb;53:274-285.

    [2]. He J, et al. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. Int J Mol Sci. 2018 Jul 12;19(7). pii: E2027.

L-heptaguluronic acid heptasodium salt(Synonyms: 古罗糖醛酸七糖)

天然产物 糖类和糖苷 Saccharides and Glycosides

L-heptaguluronic acid heptasodium salt;(Synonyms: 古罗糖醛酸七糖)

L-heptaguluronic acid heptasodium salt 是从海藻中提取的,是天然生物聚合物藻酸盐的成分。

L-heptaguluronic acid heptasodium salt(Synonyms: 古罗糖醛酸七糖)

L-heptaguluronic acid heptasodium salt Chemical Structure

CAS No. : 862694-87-9

规格 价格 是否有货
1 mg ¥1600 询问价格 货期

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生物活性

L-heptaguluronic acid heptasodium salt, extracted from seaweed, is the component of the natural biopolymers, alginates[1][2].

分子量

1404.76

Formula

C42H51Na7O43

CAS 号

862694-87-9

中文名称

古罗糖醛酸七糖

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Iwamoto M, et, al. Structure-activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cells. FEBS Lett. 2005 Aug 15; 579(20): 4423-9.

    [2]. Plazinski W, et, al. Conformational properties of acidic oligo- and disaccharides and their ability to bind calcium: a molecular modeling study. Carbohydr Res. 2012 Aug 1; 357:111-7.

D-Octamannuronic acid(Synonyms: D-甘露糖醛酸八糖)

天然产物 糖类和糖苷 Saccharides and Glycosides

D-Octamannuronic acid;(Synonyms: D-甘露糖醛酸八糖)

D-Octamannuronic acid 是一种藻酸盐低聚物,是由海洋褐藻和某些革兰氏阴性细菌产生的。D-Octamannuronic acid 可用于疼痛和血管性痴呆的研究。

D-Octamannuronic acid(Synonyms: D-甘露糖醛酸八糖)

D-Octamannuronic acid Chemical Structure

CAS No. : 862694-98-2

规格 价格 是否有货
1 mg ¥1600 询问价格 货期

* Please select Quantity before adding items.

生物活性

D-Octamannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Octamannuronic acid can be used for the research of pain and vascular dementia[1][2][3][4].

分子量

1427.01

Formula

C48H66O49

CAS 号

862694-98-2

中文名称

D-甘露糖醛酸八糖

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Heyraud A, et, al. HPLC analysis of saturated or unsaturated oligoguluronates and oligomannuronates. Application to the determination of the action pattern of Haliotis tuberculata alginate lyase. Carbohydr Res. 1996 Sep 23; 291:115-26.

    [2]. Iwamoto M, et, al. Structure-activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cells. FEBS Lett. 2005 Aug 15; 579(20): 4423-9.

    [3]. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of pain. CN106344595A.

    [4]. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of vascular dementia. CN106344593A.

4-Aza-Oleanolic acid methyl ester

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

4-Aza-Oleanolic acid methyl ester 

4-Aza-Oleanolic acid methyl ester 是一种三萜类衍生物。

4-Aza-Oleanolic acid methyl ester

4-Aza-Oleanolic acid methyl ester Chemical Structure

CAS No. : 557766-15-1

规格 是否有货
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10 mg 询价
25 mg 询价

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生物活性

4-Aza-Oleanolic acid methyl ester is a triterpenic derivative[1].

分子量

441.65

Formula

C28H43NO3

CAS 号

557766-15-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. García-Granados A, et al. Epoxides, cyclic sulfites, and sulfate from natural pentacyclic triterpenoids: theoretical calculations and chemical transformations. J Org Chem. 2003 Jun 13;68(12):4833-44.