D-Glucose 6-phosphate(Synonyms: D-葡萄糖-6-磷酸)

天然产物 糖类和糖苷 Saccharides and Glycosides

D-Glucose 6-phosphate;(Synonyms: D-葡萄糖-6-磷酸) 纯度: ge;98.0%

D-Glucose 6-phosphate 称 6-磷酸葡萄糖,是葡萄糖经过磷酸化 (在第 6 号碳) 之后生成的分子。它是生物细胞中的常见分子,参与磷酸戊糖途径与糖酵解等生化途径。

D-Glucose 6-phosphate(Synonyms: D-葡萄糖-6-磷酸)

D-Glucose 6-phosphate Chemical Structure

CAS No. : 56-73-5

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生物活性

D-Glucose 6-phosphate is a glucose sugar phosphorylated at the hydroxy group on carbon 6.

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

This dianion is very common in cells as the majority of glucose entering a cell will become phosphorylated in this way.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

260.14

Formula

C6H13O9P

CAS 号

56-73-5

中文名称

D-葡萄糖-6-磷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20deg;C, 2 years

溶解性数据
In Vitro:;

H2O : 250 mg/mL (961.02 mM; Need ultrasonic)

参考文献
  • [1]. Olsen BB, et al. Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy. Mol Imaging Biol. 2018 Jul 9.

Sphingosine-1-phosphate(Synonyms: S1P)

天然产物 糖类和糖苷 Saccharides and Glycosides

Sphingosine-1-phosphate;(Synonyms: S1P) 纯度: ge;98.0%

Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使,动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。

Sphingosine-1-phosphate(Synonyms: S1P)

Sphingosine-1-phosphate Chemical Structure

CAS No. : 26993-30-6

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生物活性

Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

S1P (1 μM) induces a significant Ca2+ releases in HEK293 cells under serum starvation conditions (1% FCS)[1].
In a functional Ca2+ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca2+ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca2+ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells[2].
In a functional Ca2+ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC50 values for gpr3 (EC50=29 nM), gpr6 (EC50=15 nM) and gpr12 (EC50=24 nM), rat gpr3 (EC50=68 nM),respectively in HEK293 cells[2].
S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

379.47

Formula

C18H38NO5P

CAS 号

26993-30-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (263.53 mM; ultrasonic and warming and heat to 60°C)

Ethanol : 20 mg/mL (52.71 mM; ultrasonic and adjust pH to 3 with HCl)

H2O : 4 mg/mL (10.54 mM; ultrasonic and warming and adjust pH to >7.5 with 0.1 M Na)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6353 mL 13.1763 mL 26.3525 mL
5 mM 0.5271 mL 2.6353 mL 5.2705 mL
10 mM 0.2635 mL 1.3176 mL 2.6353 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.59 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.59 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.59 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.59 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

  • 4.

    请依序添加每种溶剂:;10% EtOH ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2 mg/mL (5.27 mM); Clear solution

    此方案可获得 ≥ 2 mg/mL (5.27 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 5.

    请依序添加每种溶剂:;10% EtOH ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (5.27 mM); Clear solution

    此方案可获得 ≥ 2 mg/mL (5.27 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 6.

    请依序添加每种溶剂:;10% EtOH ;; 90% corn oil

    Solubility: ≥ 2 mg/mL (5.27 mM); Clear solution

    此方案可获得 ≥ 2 mg/mL (5.27 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 EtOH 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Teresa Sanchez, et al. Structural and Functional Characteristics of S1P Receptors. J Cell Biochem. 2004 Aug 1;92(5):913-22.

    [2]. Kirsten Uhlenbrock, et al. Sphingosine 1-phosphate Is a Ligand of the Human gpr3, gpr6 and gpr12 Family of Constitutively Active G Protein-Coupled Receptors. Cell Signal. 2002 Nov;14(11):941-53.

    [3]. S An, et al. Transduction of Intracellular Calcium Signals Through G Protein-Mediated Activation of Phospholipase C by Recombinant Sphingosine 1-phosphate Receptors. Mol Pharmacol. 1999 May;55(5):787-94

Potassium phosphate monobasic

生化分析试剂 Biochemical Assay Reagents
Potassium phosphate monobasic; 纯度: ge;99.0%

Potassium phosphate monobasic (DiA) 是一种常用的生物测定缓冲液。Potassium phosphate monobasic 中等至高浓度的磷酸二氢钾水溶液,用于生产磷酸盐缓冲液和其他实验室应用。

Potassium phosphate monobasic

Potassium phosphate monobasic Chemical Structure

CAS No. : 7778-77-0

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> 100 g ; 询价 ;

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生物活性

Potassium phosphate monobasic (DiA) is a commonly used in biological assay buffers. Potassium phosphate monobasic is moderate to highly concentrated aqueous solutions of potassium phosphate monobasic for the production of phosphate buffers and other laboratory applications.

分子量

136.09

Formula

H2KO4P

CAS 号

7778-77-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

4-Methylumbelliferyl phosphate(Synonyms: 4-MUP MUP)

4-Methylumbelliferyl phosphate;(Synonyms: 4-MUP; MUP) 纯度: 99.93%

4-Methylumbelliferyl phosphate (4-MUP) 是一种碱性磷酸酶的荧光底物。

4-Methylumbelliferyl phosphateamp;;(Synonyms: 4-MUP;  MUP)

4-Methylumbelliferyl phosphate Chemical Structure

CAS No. : 3368-04-5

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in Water ¥660 In-stock
50 mg ¥500 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

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4-Methylumbelliferyl phosphate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

4-Methylumbelliferyl phosphate (4-MUP) is a fluorogenic substrate of alkaline phosphatases[1].

体外研究
(In Vitro)

4-Methylumbelliferyl phosphate monoester previously described as one of a series of 4-methylumbelliferone conjugates is later found to be the PlP2-pyrophosphate diester and is not hydrolysed by serum phosphomonoesterases . 4-Methylumbelliferyl phosphate has a significant advantage over currently available substrates in that its useful concentration range extends to about 0.1 μM[1].
If the concentration of 4-Methylumbelliferyl phosphate is held constant and the pH is varied, the activity of the enzyme passes through a maximum[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

256.15

Formula

C10H9O6P

CAS 号

3368-04-5

中文名称

4-甲基伞形酮磷酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据
In Vitro:;

H2O : 20.83 mg/mL (81.32 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9040 mL 19.5198 mL 39.0396 mL
5 mM 0.7808 mL 3.9040 mL 7.8079 mL
10 mM 0.3904 mL 1.9520 mL 3.9040 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Fernley HN, et al. Kinetic behaviour of calf-intestinal alkaline phosphatase with 4-methylumbelliferyl phosphate. Biochem J. 1965 Oct;97(1):95-103.

D-Glucose 6-phosphate disodium salt

天然产物 糖类和糖苷 Saccharides and Glycosides

D-Glucose 6-phosphate disodium salt;

D-Glucose-6-phosphate disodium salt 称 6-磷酸葡萄糖,是葡萄糖经过磷酸化 (在第 6 号碳) 之后生成的分子。它是生物细胞中的常见分子,参与磷酸戊糖途径与糖酵解等生化途径。

D-Glucose 6-phosphate disodium salt

D-Glucose 6-phosphate disodium salt Chemical Structure

CAS No. : 3671-99-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in Water ¥610 In-stock
100 mg ¥550 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

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生物活性

D-Glucose-6-phosphate disodium salt is a glucose sugar phosphorylated at the hydroxy group on carbon 6[1].

体外研究
(In Vitro)

This dianion is very common in cells as the majority of glucose entering a cell will become phosphorylated in this way[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

304.10

Formula

C6H11Na2O9P

CAS 号

3671-99-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 250 mg/mL (822.10 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2884 mL 16.4420 mL 32.8839 mL
5 mM 0.6577 mL 3.2884 mL 6.5768 mL
10 mM 0.3288 mL 1.6442 mL 3.2884 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Olsen BB, et al. Linked Hexokinase and Glucose-6-Phosphatase Activities Reflect Grade of Ovarian Malignancy. Mol Imaging Biol. 2018 Jul 9.

4-Nitrophenyl phosphate disodium hexahydrate(Synonyms: p-Nitrophenyl phosphate disodium hexahydrate)

生化分析试剂 Biochemical Assay Reagents
4-Nitrophenyl phosphate disodium hexahydrate;(Synonyms: p-Nitrophenyl phosphate disodium hexahydrate)

4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate 广泛用作蛋白质酪氨酸磷酸酶活性测定中的小分子磷酸酪氨酸样底物。4-Nitrophenyl phosphate disodium hexahydrate 是一种无色基质,水解后转化为黄色的4-硝基苯酚离子,可在 405 nm 处通过吸光度监测。

4-Nitrophenyl phosphate disodium hexahydrate(Synonyms: p-Nitrophenyl phosphate disodium hexahydrate)

4-Nitrophenyl phosphate disodium hexahydrate Chemical Structure

CAS No. : 333338-18-4

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. 4-Nitrophenyl phosphate disodium hexahydrate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm[1].

体外研究
(In Vitro)

4-Nitrophenyl phosphate (PNPP) disodium hexahydrate is a commonly used substrate for alkaline phosphatases (ALPs). 4-Nitrophenyl phosphate disodium hexahydrate is hydrolyzed by ALP to PNP (p-nitrophenol), which quenches the fluorescence of novel gold nanoclusters (AuNCs) by the inner filter effect (IFE)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

371.14

Formula

C6H16NNa2O12P

CAS 号

333338-18-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Lountos GT, et al. Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate. Acta Crystallogr F Struct Biol Commun. 2015;71(Pt 2):199-205.

    [2]. Qi S, et al. Development of a facile and sensitive method for detecting alkaline phosphatase activity in serum with fluorescent gold nanoclusters based on the inner filter effect. Analyst. 2020;145(11):3871-3877.

Sodium phosphate monobasic monohydrate

生化分析试剂 Biochemical Assay Reagents
Sodium phosphate monobasic monohydrate;

Sodium phosphate monobasic monohydrate 是常用的缓冲剂。

Sodium phosphate monobasic monohydrate

Sodium phosphate monobasic monohydrate Chemical Structure

CAS No. : 10049-21-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Sodium phosphate monobasic monohydrate is a commonly used buffer[1].

分子量

137.99

Formula

H4NaO5P

CAS 号

10049-21-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Buur JL, et al. Analysis of diltiazem in Lipoderm transdermal gel using reversed-phase high-performance liquid chromatography applied to homogenization and stability studies. J Pharm Biomed Anal. 2005;38(1):60-65.

4-Methylumbelliferyl phosphate disodium salt 4-甲基伞形酮磷酸二钠盐 品牌:Chemodex


4-Methylumbelliferyl phosphate disodium salt

4-甲基伞形酮磷酸二钠盐

品牌:Chemodex
CAS No.:22919-26-2
储存条件:-20°C
纯度:>97% (NMR)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

CDX-M0012-M250

250 mg 800.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

4-Methylumbelliferyl phosphate disodium salt 4-甲基伞形酮磷酸二钠盐 品牌:Chemodex


4-Methylumbelliferyl phosphate disodium salt

4-甲基伞形酮磷酸二钠盐

品牌:Chemodex
CAS No.:22919-26-2
储存条件:-20°C
纯度:>97% (NMR)
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

CDX-M0012-G001

1 g 2,310.00


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

Phosphate Buffer Powder (1/15 mol/L, pH 6.8) 品牌:FUJIFILM Wako


Phosphate Buffer Powder (1/15 mol/L, pH 6.8)

品牌:FUJIFILM Wako
CAS No.:
储存条件:室温
纯度:
产品编号

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163-14471

for Biochemistry 1L×20 490.00


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