ANQ-11125;
ANQ-11125 是一种有效的、选择性胃动素拮抗剂，pKd 值为 8.24。ANQ-11125 在体外阻断 motilide 引起的收缩。
ANQ-11125 Chemical Structure
CAS No. : 153966-48-4
| 规格 |
|
是否有货 |
|
| 100 mg |
; |
询价 |
; |
| 250 mg |
; |
询价 |
; |
| 500 mg |
; |
询价 |
; |
* Please select Quantity before adding items.
| 生物活性 |
ANQ-11125 is a potent and selective antagonist of motilin, with the pKd of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit[1][2].
|
IC50 Target |
|
| 分子量 |
|
| Formula |
|
| CAS 号 |
|
| Sequence Shortening |
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
|
| Solvent Solubility |
In Vitro:;
H2O
Peptide Solubility and Storage Guidelines:
1.;;Calculate the length of the peptide.
2.;;Calculate the overall charge of the entire peptide according to the following table:
| ; |
Contents |
Assign value |
| Acidic amino acid |
Asp (D), Glu (E), and the C-terminal -COOH. |
-1 |
| Basic amino acid |
Arg (R), Lys (K), His (H), and the N-terminal -NH2 |
+1 |
| Neutral amino acid |
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) |
0 |
3.;;Recommended solution:
| Overall charge of peptide |
Details |
| Negative (lt;0) |
1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (gt;0) |
1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
|
| 参考文献 |
-
[1]. Depoortere I, et, al. Antagonistic properties of [Phe3,Leu13]porcine motilin. Eur J Pharmacol. 1995 Nov 24; 286(3):241-7.
[2]. Peeters TL, et, al. The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem Biophys Res Commun. 1994 Jan 28; 198(2): 411-6.
|
