GLP-1(28-36)amide TFA;
GLP-1(28-36)amide TFA 是一段 GLP-1 的 C-端九肽,是一种中性内肽酶 (NEP) 裂解 GLP-1 的主要产物。GLP-1(28-36)amide TFA 是一种抗氧化剂,靶向线粒体,抑制线粒体通透性转变 (MPT)。GLP-1(28-36)amide TFA 具有抗糖尿病和心脏保护作用。
GLP-1(28-36)amide TFA Chemical Structure
规格 | 是否有货 | ||
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100 mg | ; | 询价 | ; |
250 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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GLP-1(28-36)amide TFA 的其他形式现货产品:
生物活性 |
GLP-1(28-36)amide TFA, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide TFA is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide TFA has anti-diabetic and cardioprotection effects[1]. |
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体外研究 (In Vitro) |
Different from DPP-IV, NEP, which cleaves GLP-1(7-36)amide or GLP-1(9-36)amide to generate GLP-1(28-36)amide, is widely distributed in endothelial cells, vascular smooth muscle cells, cardiac cells and renal epithelial cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
体内研究 (In Vivo) |
The administration of GLP-1(28-36)amide at a rate of 18.5 nmol/kg BW/day for 9 weeks to diet-induced obese mice diminishes the development of hepatic steatosis[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
1202.37 |
Formula |
C56H86F3N15O11 |
Sequence |
Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 |
Sequence Shortening |
FIAWLVKGR-NH2 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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