Adipokinetic Hormone (AKH) (24-32), locust TFA

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Adipokinetic Hormone (AKH) (24-32), locust TFA;

Adipokinetic Hormone (AKH) (24-32), locust (TFA)，可从从蝗虫心脏分离得到，是调节飞行中脂质利用的神经激素。

Adipokinetic Hormone (AKH) (24-32), locust TFAamp;;

Adipokinetic Hormone (AKH) (24-32), locust TFA Chemical Structure

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生物活性

Adipokinetic Hormone (AKH) (24-32), locust (TFA), isolated from locust corpora cardiaca, is a neurohormone that regulates lipid utilisation during flight[1].

体外研究
(In Vitro)

Adipokinetic hormone (AKH) peptides in insects serve the endocrine control of energy supply. They also produce, however, neuronal, vegetative, and motor effects, suggesting that AKHs orchestrate adaptive behavior by multiple actions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1273.29

Formula

C56H75N14F3O17
Sequence Shortening

{Pyr}-LNFTPNWGT-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. J V Stone, et al. Structure of Locust Adipokinetic Hormone, a Neurohormone That Regulates Lipid Utilisation During Flight. Nature. 1976 Sep 16;263(5574):207-11.

    [2]. Dieter Wicher, et al. Differential Receptor Activation by Cockroach Adipokinetic Hormones Produces Differential Effects on Ion Currents, Neuronal Activity, and Locomotion. J Neurophysiol. 2006 Apr;95(4):2314-25.