Calcineurin autoinhibitory peptide TFA

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Calcineurin autoinhibitory peptide TFA;

Calcineurin autoinhibitory peptide TFA 是一种选择性的 Ca2+/ 钙调蛋白依赖性蛋白磷酸酶(钙调神经磷酸酶)的抑制剂，IC50 值大约为 10 μM。Calcineurin autoinhibitory peptide TFA 可以保护神经元免受兴奋性神经元死亡。

Calcineurin autoinhibitory peptide TFAamp;;

Calcineurin autoinhibitory peptide TFA Chemical Structure

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Calcineurin autoinhibitory peptide TFA 的其他形式现货产品:

Calcineurin autoinhibitory peptide

生物活性

Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death[1][2].

IC50 Target

IC50: ~10 μM (calcineurin)[1]
分子量

3044.34

Formula

C126H206F3N39O41S2
Sequence Shortening

ITSFEEAKGLDRINERMPPRRDAMP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7.

    [2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.