N-terminally acetylated Leu-enkephalin(Synonyms: Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH)

发表于由

N-terminally acetylated Leu-enkephalin;(Synonyms: Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH) 纯度: 99.01%

N-terminally acetylated Leu-enkephalin 是N-末端乙酰化的 Leu-enkephalin。Leu-enkephalin是一种五氨基酸的内源性肽，作为阿片受体的激动剂。

N-terminally acetylated Leu-enkephalinamp;;(Synonyms: Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH)

N-terminally acetylated Leu-enkephalin Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1100 In-stock
5 mg ￥2200 In-stock
10 mg ￥3500 In-stock
25 mg ￥7500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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N-terminally acetylated Leu-enkephalin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptidomimetic Library
  • Peptide Library

生物活性

N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

体外研究
(In Vitro)

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

597.66

Formula

C30H39N5O8
Sequence

Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH
Sequence Shortening

Ac-LYGGLFDL-COOH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.