[D-Ala2]leucine-enkephalin

发表于2024年4月25日由Whatman官网

[D-Ala2]leucine-enkephalin; 纯度: 99.19%

[D-Ala2]leucine-enkephalin 是一种 δ 阿片类 (delta opioid) 激动剂，是一种能长效抗降解的亮氨酸脑非肽。

[D-Ala2]leucine-enkephalin Chemical Structure

CAS No. : 64963-01-5

规格	价格	是否有货	数量
10;mM;*;1 mL in Water	￥752	In-stock
5 mg	￥600	In-stock
10 mg	￥900	In-stock
50 mg	￥3500	In-stock
100 mg	;	询价	;
200 mg	;	询价	;

* Please select Quantity before adding items.

[D-Ala2]leucine-enkephalin 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
GPCR/G Protein Compound Library
Neuronal Signaling Compound Library
Anti-Cancer Compound Library
Peptidomimetic Library
Neurotransmitter Receptor Compound Library
Peptide Library

生物活性

[D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

分子量

569.65

Formula

C₂₉H₃₉N₅O₇

CAS 号

64963-01-5

Sequence

Tyr-{d-Ala}-Gly-Phe-Leu

Sequence Shortening

Y-{d-Ala}-GFL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

H₂O : 50 mg/mL (87.77 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7555 mL	8.7773 mL	17.5546 mL
5 mM	0.3511 mL	1.7555 mL	3.5109 mL
10 mM	0.1755 mL	0.8777 mL	1.7555 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

[Met5]-Enkephalin, amide TFA(Synonyms: 5-Methionine-enkephalin amide TFA)

发表于2024年4月23日由Whatman官网

[Met5]-Enkephalin, amide TFA;(Synonyms: 5-Methionine-enkephalin amide TFA) 纯度: 99.71%

[Met5]-Enkephalin, amide TFA 是一种 δ 和 ζ 阿片受体 (opioid receptor) 激动剂。

[Met5]-Enkephalin, amide TFAamp;;(Synonyms: 5-Methionine-enkephalin amide TFA)

[Met5]-Enkephalin, amide TFA Chemical Structure

规格	价格	是否有货	数量
10 mg	￥600	In-stock
25 mg	￥1200	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

[Met5]-Enkephalin, amide TFA 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

IC₅₀ Target

δ and ζ opioid receptor^[1]

体外研究
(In Vitro)

[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture^[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC₅₀ value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

686.70

Formula

C₂₉H₃₇F₃N₆O₈S

Sequence

Tyr-Gly-Gly-Phe-Met-NH2

Sequence Shortening

YGGFM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80deg;C	2 years
	-20deg;C	1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:;

H₂O : 100 mg/mL (145.62 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4562 mL	7.2812 mL	14.5624 mL
5 mM	0.2912 mL	1.4562 mL	2.9125 mL
10 mM	0.1456 mL	0.7281 mL	1.4562 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48.

[2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.