标签归档：enkephalin

N-terminally acetylated Leu-enkephalin(Synonyms: Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH)

发表于由

N-terminally acetylated Leu-enkephalin;(Synonyms: Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH) 纯度: 99.01%

N-terminally acetylated Leu-enkephalin 是N-末端乙酰化的 Leu-enkephalin。Leu-enkephalin是一种五氨基酸的内源性肽，作为阿片受体的激动剂。

N-terminally acetylated Leu-enkephalinamp;;(Synonyms: Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH)

N-terminally acetylated Leu-enkephalin Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1100 In-stock
5 mg ￥2200 In-stock
10 mg ￥3500 In-stock
25 mg ￥7500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

N-terminally acetylated Leu-enkephalin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptidomimetic Library
  • Peptide Library

生物活性

N-terminally acetylated Leu-enkephalin is the N-terminally acetylated form of Leu-enkephalin. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

体外研究
(In Vitro)

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

597.66

Formula

C30H39N5O8
Sequence

Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH
Sequence Shortening

Ac-LYGGLFDL-COOH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

[Leu5]-Enkephalin(Synonyms: Leu-enkephalin Leucine enkephalin Leucyl-enkephalin)

发表于由

[Leu5]-Enkephalin;(Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin) 纯度: 99.81%

[Leu5]-Enkephalin 是一种具有吗啡药性的五肽。作为阿片受体 (opioid receptors) 激动剂。

[Leu5]-Enkephalinamp;;(Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin)

[Leu5]-Enkephalin Chemical Structure

CAS No. : 58822-25-6

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥605 In-stock
10 mg ￥550 In-stock
25 mg ￥1100 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

[Leu5]-Enkephalin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Metabolism/Protease Compound Library
  • Neuronal Signaling Compound Library
  • Natural Product Library
  • Human Endogenous Metabolite Compound Library
  • Peptidomimetic Library
  • Phenols Library
  • Neurotransmitter Receptor Compound Library

生物活性

[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

555.62

Formula

C28H37N5O7
CAS 号

58822-25-6
Sequence

Tyr-Gly-Gly-Phe-Leu
Sequence Shortening

YGGFL
中文名称

[Leu5]-脑啡肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 150 mg/mL (269.97 mM)

H2O : 100 mg/mL (179.98 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7998 mL 8.9990 mL 17.9979 mL
5 mM 0.3600 mL 1.7998 mL 3.5996 mL
10 mM 0.1800 mL 0.8999 mL 1.7998 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

    [2]. Meunier JC, et al. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 1977 May 15;77(2):209-13.

[D-Ala2]leucine-enkephalin

发表于由

[D-Ala2]leucine-enkephalin; 纯度: 99.19%

[D-Ala2]leucine-enkephalin 是一种 δ 阿片类 (delta opioid) 激动剂，是一种能长效抗降解的亮氨酸脑非肽。

[D-Ala2]leucine-enkephalinamp;;

[D-Ala2]leucine-enkephalin Chemical Structure

CAS No. : 64963-01-5

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥752 In-stock
5 mg ￥600 In-stock
10 mg ￥900 In-stock
50 mg ￥3500 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

* Please select Quantity before adding items.

[D-Ala2]leucine-enkephalin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Anti-Cancer Compound Library
  • Peptidomimetic Library
  • Neurotransmitter Receptor Compound Library
  • Peptide Library

生物活性

[D-Ala2]leucine-enkephalin, a delta opioid agonist, is a degradation resistant long-acting Leu-enkephalin.

分子量

569.65

Formula

C29H39N5O7
CAS 号

64963-01-5
Sequence

Tyr-{d-Ala}-Gly-Phe-Leu
Sequence Shortening

Y-{d-Ala}-GFL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (87.77 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7555 mL 8.7773 mL 17.5546 mL
5 mM 0.3511 mL 1.7555 mL 3.5109 mL
10 mM 0.1755 mL 0.8777 mL 1.7555 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

[Met5]-Enkephalin, amide TFA(Synonyms: 5-Methionine-enkephalin amide TFA)

发表于由

[Met5]-Enkephalin, amide TFA;(Synonyms: 5-Methionine-enkephalin amide TFA) 纯度: 99.71%

[Met5]-Enkephalin, amide TFA 是一种 δ 和 ζ 阿片受体 (opioid receptor) 激动剂。

[Met5]-Enkephalin, amide TFAamp;;(Synonyms: 5-Methionine-enkephalin amide TFA)

[Met5]-Enkephalin, amide TFA Chemical Structure

规格 价格 是否有货 数量
10 mg ￥600 In-stock
25 mg ￥1200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

[Met5]-Enkephalin, amide TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

[Met5]-Enkephalin, amide TFA is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

IC50 Target

δ and ζ opioid receptor[1]
体外研究
(In Vitro)

[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

686.70

Formula

C29H37F3N6O8S
Sequence

Tyr-Gly-Gly-Phe-Met-NH2
Sequence Shortening

YGGFM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (145.62 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4562 mL 7.2812 mL 14.5624 mL
5 mM 0.2912 mL 1.4562 mL 2.9125 mL
10 mM 0.1456 mL 0.7281 mL 1.4562 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48.

    [2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.

(Leu5)-Enkephalin （亮氨酸5）-脑啡肽 品牌：Peptide

发表于由

(Leu5)-Enkephalin

（亮氨酸5）-脑啡肽

品牌：Peptide
CAS No.：58822-25-6
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-40431

 – 0.5mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

[D-Ala2,Met5]-Enkephalin 品牌：Peptide

发表于由

[D-Ala2,Met5]-Enkephalin

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

337-41163

 – 25mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

[D-Ala2,D-Leu5]-Enkephalin 品牌：Peptide

发表于由

[D-Ala2,D-Leu5]-Enkephalin

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

334-41151

 – 0.5mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

(Leu5)-Enkephalin （亮氨酸5）-脑啡肽 品牌：Peptide

发表于由

(Leu5)-Enkephalin

（亮氨酸5）-脑啡肽

品牌：Peptide
CAS No.：58822-25-6
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

330-40433

 – 25mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Amidorphin / Pro-Enkephalin A (104-129 Amide) (Bovine) 品牌：Anygen

发表于由

Amidorphin / Pro-Enkephalin A (104-129 Amide) (Bovine)

品牌：Anygen
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

301-90851

 – 0.5 mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

[D-Ala2,D-Leu5]-Enkephalin 品牌：Peptide

发表于由

[D-Ala2,D-Leu5]-Enkephalin

品牌：Peptide
CAS No.：
储存条件：-20℃
纯度：–
产品编号

(生产商编号)

 等级 规格 运输包装 零售价(RMB) 库存情况 参考值

330-41153

 – 100mg – 咨询 – –


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。