Pep2-8

发表于由

Pep2-8; 纯度: 99.01%

Pep2-8 是 PCSK9 抑制剂，其 KD 值为 0.7 μM，IC50 值为1.4 μM。

Pep2-8amp;;

Pep2-8 Chemical Structure

CAS No. : 1541011-97-5

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生物活性

Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM[1].

体外研究
(In Vitro)

Pep2-8 binds to C-terminally truncated PCSK9[1].
Pep2-8 restored LDL uptake of PCSK9-treated HepG2 cells to about 90% of control activity at a concentration of 50 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cell.
Concentration: 15 μg/mL.
Incubation Time: 4 h.
Result: Inhibited PCSK9 activity.

分子量

1715.85

Formula

C83H110N16O24
CAS 号

1541011-97-5
Sequence Shortening

Ac-TVFTSWEEYLDWV-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
参考文献

  • [1]. Yingnan Zhang, et al. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem. 2014 Jan 10;289(2):942-55.