Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM[1].
体外研究 (In Vitro)
Pep2-8 binds to C-terminally truncated PCSK9[1]. Pep2-8 restored LDL uptake of PCSK9-treated HepG2 cells to about 90% of control activity at a concentration of 50 μM[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[1]
Cell Line:
HepG2 cell.
Concentration:
15 μg/mL.
Incubation Time:
4 h.
Result:
Inhibited PCSK9 activity.
分子量
1715.85
Formula
C83H110N16O24
CAS 号
1541011-97-5
Sequence Shortening
Ac-TVFTSWEEYLDWV-NH2
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Yingnan Zhang, et al. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem. 2014 Jan 10;289(2):942-55.
Pinostrobin is a flavonoid can be found in many plants, and has anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. Pinostrobin is a potent PCSK9 inhibitor and inhibits the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management[1].
IC50 & Target
IC50: PCSK9[1]
分子量
270.28
Formula
C16H14O4
CAS 号
480-37-5
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Gao WY, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells.J Agric Food Chem. 2018 Jun 20;66(24):6083-6093.