生化分析试剂 Biochemical Assay Reagents
EGTA; 纯度: ge;98.0%
EGTA 是一种特殊的钙离子螯合剂。EGTA 在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。
EGTA Chemical Structure
CAS No. : 67-42-5
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 500 mg | ￥500 | In-stock | |
| 1 g | ￥850 | In-stock | |
| 5 g | ; | 询价 | ; |
| 10 g | ; | 询价 | ; |
* Please select Quantity before adding items.
EGTA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
| 生物活性 |
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2]. |
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| 体外研究 (In Vitro) |
EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
380.35 |
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| Formula |
C14H24N2O10 |
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| CAS 号 |
67-42-5 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:;
H2O : 5 mg/mL (13.15 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C) DMSO : 1 mg/mL (2.63 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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| 参考文献 |
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