Gelucire 44/14(Synonyms: 月桂酸聚乙二醇甘油酯) | Cytiva思拓凡-Whatman滤纸滤膜滤器

生化分析试剂 Biochemical Assay Reagents
Gelucire 44/14;(Synonyms: 月桂酸聚乙二醇甘油酯) 纯度: ge;96.0%

Gelucire 44/14 是一种强效且安全的吸收促进剂，用于改善通过肺部递送的难吸收药物的吸收包括胰岛素和降钙素在内。

Gelucire 44/14 Chemical Structure

CAS No. : 121548-04-7

规格	价格	是否有货	数量
25 g	￥500	In-stock
50 g	￥800	In-stock
100 g	￥1300	In-stock
> 100 g	;	询价	;

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生物活性

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery.

体内研究
(In Vivo)

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery. It is found that pulmonary absorptions of FD4, FD10 and FD70 are enhanced in different degree by Gelucire 44/14 in a concentration-dependent manner, and the maximal absorption-enhancing effect is obtained when the concentration of Gelucire 44/14 reaches to 2.0% (w/v). It is also found that the absorption enhancing ability of Gelucire Gelucire 44/14 is correlated with the molecular weight of model drugs, and the highest absorption enhancement ratio of Gelucire Gelucire 14/44 is observed when the molecular weight of model drugs reaches to nearly 10000 Da^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号

121548-04-7

中文名称

月桂酸聚乙二醇甘油酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20deg;C	3 years
	4deg;C	2 years

溶解性数据

In Vitro:;

Ethanol : 50 mg/mL (Need ultrasonic)

参考文献

[1]. Zhang H, et al. Improvement of pulmonary absorptions of poorly absorbable drugs using Gelucire 44/14 as an absorption enhancer. J Pharm Pharmacol. 2014 Oct;66(10):1410-20.

Animal Administration ^[1]	Male Sprague Dawley rats are used to evaluate the pulmonary membrane toxicity of Gelucire 44/14. PBS (pH 7.4) with or without Gelucire 44/14 are directly administered to the tracheae of the rats according to the in-situ pulmonary absorption experiments. Four hours later, the rats are bled from the abdominal aorta, and then PBS (pH7.4) is perfused into the rat lung along the trachea. Afterwards, bronchoalveolar lavage fluid (BALF) of rat in each group is collected and kept in ice immediately until determination^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Zhang H, et al. Improvement of pulmonary absorptions of poorly absorbable drugs using Gelucire 44/14 as an absorption enhancer. J Pharm Pharmacol. 2014 Oct;66(10):1410-20.

Animal Administration
^[1]

Male Sprague Dawley rats are used to evaluate the pulmonary membrane toxicity of Gelucire 44/14. PBS (pH 7.4) with or without Gelucire 44/14 are directly administered to the tracheae of the rats according to the in-situ pulmonary absorption experiments. Four hours later, the rats are bled from the abdominal aorta, and then PBS (pH7.4) is perfused into the rat lung along the trachea. Afterwards, bronchoalveolar lavage fluid (BALF) of rat in each group is collected and kept in ice immediately until determination^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Zhang H, et al. Improvement of pulmonary absorptions of poorly absorbable drugs using Gelucire 44/14 as an absorption enhancer. J Pharm Pharmacol. 2014 Oct;66(10):1410-20.