DIDS sodium salt;(Synonyms: MDL101114ZA) 纯度: ge;99.0%
DIDS sodium salt (MDL101114ZA) 是 ABCA1 和 VDAC1 的双抑制剂。
DIDS sodium salt Chemical Structure
CAS No. : 67483-13-0
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥1089 | In-stock | |
50 mg | ¥990 | In-stock | |
100 mg | ; | 询价 | ; |
200 mg | ; | 询价 | ; |
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DIDS sodium salt 相关产品
bull;相关化合物库:
- Targeted Diversity Library
- Bioactive Compound Library Plus
- Membrane Transporter/Ion Channel Compound Library
生物活性 |
DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor. |
IC50 Target |
ABCA1[1], VDAC1[2]. |
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体外研究 (In Vitro) |
Concentration less than 400 μM DIDS has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. At the concentration of 400 μM DIDS itself slightly decreases the cell viability, although there is no significant statistic difference as compared with the untreated control. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
498.48 |
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Formula |
C16H8N2Na2O6S4 |
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CAS 号 |
67483-13-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
-20deg;C, sealed storage, away from moisture *In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:;
DMSO : 50 mg/mL (100.30 mM; Need ultrasonic) H2O : 33.33 mg/mL (66.86 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay |
Cells (5×105 cells/mL) are seeded in the 35-mm Petri dishes and cultured for 72 h at 37°C. Cells are pre-incubated with ALA, and then DIDS of diverse concentrations (0-200 μM) is added before exposed to ultrasound. Cell apoptosis is detected. Briefly, seeded cells (5×105 cells/mL) are pre-treated with test compounds at the indicated concentrations for 1 h (DIDS and NAC), 1.5 h (BAPTA) or with siRNA and exposed to ultrasound. Six hours after ALA-SDT treatment, cells are collected[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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