Cortistatin-14(Synonyms: 皮质抑素-14)

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Cortistatin-14;(Synonyms: 皮质抑素-14) 纯度: 99.93%

Cortistatin-14 是一种与生长抑素-14结构相似的神经肽，通过生长抑素受体 (sst1-sst5) 结合并发挥作用。Cortistatin-14具有抗惊厥、神经保护作用和显著的抗炎作用。

Cortistatin-14amp;;(Synonyms: 皮质抑素-14)

Cortistatin-14 Chemical Structure

CAS No. : 186901-48-4

规格 价格 是否有货 数量
500 μg ￥650 In-stock
1 mg ￥1200 In-stock
5 mg ￥4800 In-stock
10 mg ￥8600 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Cortistatin-14 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4].

分子量

1720.03

Formula

C81H114N20O18S2
CAS 号

186901-48-4
Sequence

{Pro}{Cys}{Lys}{Asn}{Phe}{Phe}{Trp}{Lys}{Thr}{Phe}{Ser}{Ser}{Cys}{Lys}-NH2 (Disulfide bridge: Cys2-Cys13)
Sequence Shortening

PCKNFFWKTFSSCK-NH2 (Disulfide bridge: Cys2-Cys13)
中文名称

皮质抑素-14
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (29.07 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5814 mL 2.9069 mL 5.8139 mL
5 mM 0.1163 mL 0.5814 mL 1.1628 mL
10 mM 0.0581 mL 0.2907 mL 0.5814 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.

    [2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6.

    [3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60.

    [4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50.

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