[Leu5]-Enkephalin(Synonyms: Leu-enkephalin Leucine enkephalin Leucyl-enkephalin)

发表于由

[Leu5]-Enkephalin;(Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin) 纯度: 99.81%

[Leu5]-Enkephalin 是一种具有吗啡药性的五肽。作为阿片受体 (opioid receptors) 激动剂。

[Leu5]-Enkephalinamp;;(Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin)

[Leu5]-Enkephalin Chemical Structure

CAS No. : 58822-25-6

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥605 In-stock
10 mg ￥550 In-stock
25 mg ￥1100 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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[Leu5]-Enkephalin 相关产品

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生物活性

[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

555.62

Formula

C28H37N5O7
CAS 号

58822-25-6
Sequence

Tyr-Gly-Gly-Phe-Leu
Sequence Shortening

YGGFL
中文名称

[Leu5]-脑啡肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : ≥ 150 mg/mL (269.97 mM)

H2O : 100 mg/mL (179.98 mM; Need ultrasonic)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7998 mL 8.9990 mL 17.9979 mL
5 mM 0.3600 mL 1.7998 mL 3.5996 mL
10 mM 0.1800 mL 0.8999 mL 1.7998 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

    [2]. Meunier JC, et al. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 1977 May 15;77(2):209-13.