日度归档：2024年5月9日

荧光染料BODIPY-Cholesterol

发表于由

荧光染料Dye Reagents BODIPY-Cholesterol; 纯度: ge;98.0%

BODIPY-cholesterol 是一种带有荧光 BODIPY 基团的亲脂性和细胞通透性胆固醇类似物。BODIPY-cholesterol 可用于监测细胞内固醇摄取和细胞器间固醇通量。(激发/发射波长: 480/508 nm)。

BODIPY-Cholesterolamp;;

BODIPY-Cholesterol Chemical Structure

CAS No. : 878557-19-8

规格 价格 是否有货 数量
1 mg ￥4000 In-stock
5 mg ￥9500 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

BODIPY-Cholesterol 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

BODIPY-cholesterol is an intrinsically lipophilic, and cell-permeable analog of cholesterol with a fluorescent BODIPY group. BODIPY-cholesterol can be used to monitor sterol uptake and inter-organelle sterol flux in cells. (Excitation/Emission: 480/508 nm)[1].

体外研究
(In Vitro)

BODIPY-cholesterol assay
To prepare a stock solution of BODIPY-cholesterol for this assay, the analogue is reconstituted in DMSO to a stock concentration of 1-10 μM[1].
Cells diluted with PBS (or other buffers) are washed (300×g, 10 min) to remove excess diluent and the loose pellet resuspended with vehicle media to a proper concentration[1].
Cell suspensions are labeled with BODIPY-cholesterol (final concentration of 0.5-5 µM), mixed thoroughly and incubated for 10 -20 mins at 37 °C[1].
The cells are diluted with each of the capacitation media conditions as outlined in Incubation media to a final concentration and incubated for 2 h prior to flow cytometric assessment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

576.61

Formula

C36H51BF2N2O
CAS 号

878557-19-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 1 mg/mL (1.73 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7343 mL 8.6714 mL 17.3427 mL
5 mM — — —
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Daniel Wüstner, et al.Potential of BODIPY-cholesterol for analysis of cholesterol transport and diffusion in living cells. Chem Phys Lipids. 2016 Jan;194:12-28.

    [2]. Maarit Hölttä-Vuori, et al. BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organiss. Traffic. 2008 Nov;9(11):1839-49.

1005-125-沃特曼定性滤纸NO5慢速滤纸125mm直径

发表于由
  • 型号 1005-125
  • 品牌 GE whatman沃特曼
  • 【简单介绍】

    沃特曼定性滤纸NO5慢速滤纸125mm直径 1005-125，可以收集在化学分析中遇到的细小沉淀物。流速较慢。适合做化学分析、澄清悬浮物和水/泥土分析。

    沃特曼定性滤纸NO5慢速滤纸125mm直径 1005-125

    Whatman定性滤纸用于定性分析技术中鉴定物质的性质。折叠好的定性滤纸与相同型号平整的滤纸相比，加快了流速并增加了负载力。
    Grade 5:2.5μm
    在定性范围内，程度地截留颗粒。可以收集在化学分析中遇到的细小沉淀物。流速较慢。适合做化学分析、澄清悬浮物和水/泥土分析。已折叠好的为Grade 5V。

    沃特曼定性滤纸NO5慢速滤纸125mm直径 1005-125

    1005-125-沃特曼定性滤纸NO5慢速滤纸125mm直径

Ingenol(Synonyms: 巨大戟醇; (-)-Ingenol)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Ingenol (Synonyms: 巨大戟醇; (-)-Ingenol) 纯度: 98.17%

Ingenol 是一种 PKC 激活剂，Ki 值为 30 μM，具有抗肿瘤活性。

Ingenol(Synonyms: 巨大戟醇; (-)-Ingenol)

Ingenol Chemical Structure

CAS No. : 30220-46-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1089 In-stock
5 mg ￥990 In-stock
10 mg ￥1200 In-stock
50 mg ￥4500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Ingenol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Kinase Inhibitor Library
  • TGF-beta/Smad Compound Library
  • Natural Product Library
  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
  • Drug Repurposing Compound Library
  • Oxygen Sensing Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Cytoskeleton Compound Library
  • Traditional Chinese Medicine Monomer Library
  • FDA Approved & Pharmacopeial Drug Library

生物活性

Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.

IC50 & Target[1]

PKC

30 μM (Ki)

体外研究
(In Vitro)

Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

348.43

Formula

C20H28O5
CAS 号

30220-46-3
中文名称

巨大戟醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (287.00 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8700 mL 14.3501 mL 28.7002 mL
5 mM 0.5740 mL 2.8700 mL 5.7400 mL
10 mM 0.2870 mL 1.4350 mL 2.8700 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.18 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.18 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.18 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Hasler CM, et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan 1;52(1):202-8.

OVA Peptide(257-264) TFA

发表于由

OVA Peptide(257-264) TFA; 纯度: 98.78%

OVA Peptide(257-264) TFA 是 OVA 的 I 类 (Kb)-限制性肽表位，OVA 是由 I 类 MHC 分子 H-2Kb 呈递的来自卵清蛋白的八聚体肽。

OVA Peptide(257-264) TFAamp;;

OVA Peptide(257-264) TFA Chemical Structure

CAS No. : 1262751-08-5

规格 价格 是否有货 数量
1 mg ￥900 In-stock
5 mg ￥3600 In-stock
10 mg ￥5600 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

OVA Peptide(257-264) TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

OVA Peptide(257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb.

体外研究
(In Vitro)

TAP1-I- and C57BL/6 macrophages may process Crl-OVA and full-length OVA in different cellular compartments and that the protein context of the OVA Peptide(257-264) epitope influences the extent of TAP-independent processing for MHC class I presentation. OVA Peptide(257-264) epitope is presented with a differential dependence on the TAP transporter depending on the protein context of the OVA epitope: OVA Peptide(257-264) contained within the MBPCrl-OVA or Crl-OVA bacterial fusion proteins is presented with little dependence on the TAP transporter, while OVA Peptide(257-264) contained within full-length ovalbumin is largely dependent on the TAP transporter, regardless of whether recombinant OVA is expressed in bacteria or the native protein is coupled to polystyrene beads[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1077.15

Formula

C47H75F3N10O15
CAS 号

1262751-08-5
Sequence

Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu
Sequence Shortening

SIINFEKL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 20 mg/mL (18.57 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9284 mL 4.6419 mL 9.2838 mL
5 mM 0.1857 mL 0.9284 mL 1.8568 mL
10 mM 0.0928 mL 0.4642 mL 0.9284 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.08 mg/mL (1.93 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.93 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Wick MJ, et al. Major histocompatibility complex class I presentation of ovalbumin peptide 257-264 from exogenous sources: protein context influences the degree of TAP-independent presentation. Eur J Immunol. 1996 Nov;26(11):2790-9.
Cell Assay

TAPl-/- or C57BL/6 macrophages are co-incubated with either bacteria or polystyrene beads containing the 257-264 epitope from ovalbumin [OVA Peptide(257-264)], which binds the mouse class I molecule Kb. The source of the OVA(257-264) epitope is either the Crl-OVA(257-264) (Crl-OVA) fusion protein, the maltose binding protein (MBP)-Crl-OVA fusion protein, native OVA or bacterial recombinant OVA (rOVA); Crl-OVA, MBP-Crl-OVA and rOVA are each expressed in bacteria, and Crl-OVA and MBP-Crl-OVA purified from bacterial lysates and native egg OVA are coated onto polystyrene beads[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Wick MJ, et al. Major histocompatibility complex class I presentation of ovalbumin peptide 257-264 from exogenous sources: protein context influences the degree of TAP-independent presentation. Eur J Immunol. 1996 Nov;26(11):2790-9.

荧光染料Alkyne-probe 1

发表于由

荧光染料Dye Reagents Alkyne-probe 1;

Alkyne-probe 1 是 Alkyne标记的化学或荧光探针。

Alkyne-probe 1

Alkyne-probe 1 Chemical Structure

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Alkyne-probe 1 is usually used as a Alkyne-labeled chemical or fluorescent probe.

分子量

293.36

Formula

C14H23N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Rhodamine B(Synonyms: 罗丹明B Basic Violet 10 Brilliant Pink B Rhodamine O Tetraethylrhodamine)

发表于由

Rhodamine B;(Synonyms: 罗丹明B; Basic Violet 10; Brilliant Pink B; Rhodamine O; Tetraethylrhodamine) 纯度: 98.03%

Rhodamine B 是一种荧光染料，常用于染色纺织品、纸张、肥皂、皮革和药品。

Rhodamine Bamp;;(Synonyms: 罗丹明B; Basic Violet 10; Brilliant Pink B; Rhodamine O; Tetraethylrhodamine)

Rhodamine B Chemical Structure

CAS No. : 81-88-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
1 g ￥800 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

* Please select Quantity before adding items.

Rhodamine B 相关产品

bull;相关化合物库:

  • FDA Approved amp; Pharmacopeial Drug Library
  • Inactive Ingredient Library
  • Tumorigenesis Related Compound Library
  • Bioactive Compound Library Plus

生物活性

Rhodamine B is a staining fluorescent dye, commonly used for dyeing textiles, paper, soap, leather, and drugs.

体外研究
(In Vitro)

Rhodamine B induces a concentration-dependent reduction of root meristem cells of A. cepa. mitotic activity. Rhodamine B induces various nuclear aberrations in A. cepa. root cells. In the 100 and 200 ppm rhodamine B groups, the frequencies of NBUDs and BN surpass those of the positive control (MMS) group. Rhodamine B-induced changes of H2O2 (a) and MDA (b) level increase in a concentration-dependent manner in A. cepa. roots[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

479.01

Formula

C28H31ClN2O3
CAS 号

81-88-9
中文名称

罗丹明B；玫瑰红B；蕊香红B；若丹明B；碱性玫瑰精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

DMSO : 125 mg/mL (260.95 mM; Need ultrasonic)

H2O : 100 mg/mL (208.76 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0876 mL 10.4382 mL 20.8764 mL
5 mM 0.4175 mL 2.0876 mL 4.1753 mL
10 mM 0.2088 mL 1.0438 mL 2.0876 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (4.34 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.34 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Tan D, et al. Rhodamine B induces long nucleoplasmic bridges and other nuclear anomalies in Allium cepa root tip cells. Environ Sci Pollut Res Int. 2014 Mar;21(5):3363-70.

荧光染料MCLA hydrochloride

发表于由

荧光染料Dye Reagents MCLA hydrochloride; 纯度: ge;99.0%

MCLA hydrochloride 是一种化学发光试剂，可用于定量超氧化物的含水量。

MCLA hydrochloride

MCLA hydrochloride Chemical Structure

CAS No. : 128322-44-1

规格 价格 是否有货 数量
1 mg ￥1200 In-stock
5 mg ￥2450 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

MCLA hydrochloride is a chemiluminescent reagent which can be used to quantify aqueous concentrations of superoxide.

体外研究
(In Vitro)

The non-specific luminescence remains almost constant for 10 min after the addition of MCLA hydrochloride (MCLA) and is not significantly influenced by SOD. The MCLA hydrochloride method is, however, 4.5-times more sensitive than the CLA method[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

291.73

Formula

C14H14ClN3O2
CAS 号

128322-44-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Kimura H, et al. Highly sensitive and reliable chemiluminescence method for the assay of superoxide dismutase inhuman erythrocytes. FEBS Lett. 1988 Nov 7;239(2):347-50.
Kinase Assay
[1]

The standard reaction mixture contains 1×l0-7 M MCLA hydrochloride (MCLA), 5×10-5 M hypoxanthine, XOD (6.5 U), SOD (0.2 to 20 ng/mL) or none, and 50 mM Tris-HCl buffer containing 0.1 mM EDTA at pH 7.8, in a total volume of 3.0 mL. Chemiluminescence measurement is initiated by the addition of MCLA hydrochloride to the standard incubation mixture excluding XOD, continued for 4 min without additive and for an additional 4 min after the addition of XOD. Chemiluminescence is measured using a luminescence reader at 25°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Kimura H, et al. Highly sensitive and reliable chemiluminescence method for the assay of superoxide dismutase inhuman erythrocytes. FEBS Lett. 1988 Nov 7;239(2):347-50.

Danshenxinkun B(Synonyms: 丹参新醌乙)

发表于由

天然产物醌类Quinones

Danshenxinkun B (Synonyms: 丹参新醌乙)

Danshenxinkun B 是存在于tanshen (Salvia miltiorhiza Bung) 中的一种抗氧化活性成分。

Danshenxinkun B(Synonyms: 丹参新醌乙)

Danshenxinkun B Chemical Structure

CAS No. : 65907-76-8

规格 价格 是否有货
1 mg ￥4760 询问价格 & 货期
5 mg ￥14290 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Danshenxinkun B is an antioxidative component of tanshen (Salvia miltiorhiza Bung) [1].

分子量

280.32

Formula

C18H16O3
CAS 号

65907-76-8
中文名称

丹参新醌乙
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang, K, et al. Antioxidative components of tanshen (Salvia miltiorhiza Bung). Journal of Agricultural and Food Chemistry, 38(5), 1194–1197.

millipore聚碳酸酯膜GTTP04700 GTTP04700

发表于由

millipore聚碳酸酯膜GTTP04700

millipore聚碳酸酯膜GTTP04700， ISOPORE 表面滤膜 millipore聚碳酸酯膜GTTP04700 规格：孔径0.2 μm，直径47 mm，白色光面 数量/包装:100

 millipore   聚碳酸酯膜   ISOPORE 表面滤膜是在聚碳酸酯表面径迹蚀刻而成，推荐用于所有需要在滤膜表面观察样品的分析。ISPOPRE表面滤膜具有独特的适用性，通过光学或电子显微镜技术对空气中的污染物及其它颗粒进行观察分析。ISOPORE表面滤膜由聚碳酸酯膜组成，具有光滑的，像玻璃一样的表面，可以进行清晰的样品观察，该表面滤膜独有的生产工艺保证了均一的孔径，可进行**的依据孔径的分离。不吸湿，可以很快干燥，缩短样品分析时间。

millipore   聚碳酸酯膜
  应用于趋药性分析，生物分析，细胞学，空气监测，SEM分析，无菌试验
技术指标：

    23 °C 时的泡点:≥3.5 bar
    *高操作温度：140°C
    可润湿性:亲水
    厚度：7-22μm
    重量分析溶出物:   <1.0%
    成功率 5-20%

    除微生物方法：高温高压（121°C，1bar），EO或Y射线

 

Isoquercitrin(Synonyms: Isoquercitroside)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Isoquercitrin;(Synonyms: Isoquercitroside) 纯度: 99.95%

Isoquercitrin (Isoquercitroside) 是一种有效的抗氧化剂和嗜酸性炎症抑制剂。

Isoquercitrin(Synonyms: Isoquercitroside)

Isoquercitrin Chemical Structure

CAS No. : 21637-25-2

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ￥660 In-stock
10 mg ￥600 In-stock
50 mg ￥2100 In-stock
100 mg ￥3600 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Isoquercitrin 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • NF-kappa;B Signaling Compound Library
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  • Natural Product Library
  • Anti-Aging Compound Library
  • Antioxidants Compound Library
  • Oxygen Sensing Compound Library
  • Ferroptosis Compound Library
  • Phenols Library
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  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Mitochondria-Targeted Compound Library

生物活性

Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor.

体外研究
(In Vitro)

Isoquercitrin occurs widely in plants.10 μM of Isoquercitrin of the seven compounds partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In animals receiving Isoquercitrin, eosinophil counts are lower in the BALF, blood and lung parenchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate are lower only in Isoquercitrin-treated mice. No alterations in mononuclear cell numbers were observed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

464.38

Formula

C21H20O12
CAS 号

21637-25-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 125 mg/mL (269.18 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1534 mL 10.7670 mL 21.5341 mL
5 mM 0.4307 mL 2.1534 mL 4.3068 mL
10 mM 0.2153 mL 1.0767 mL 2.1534 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.48 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.48 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21.

    [2]. Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8.
Animal Administration
[2]

Mice[2]
BALB/c mice are immunized (ovalbumin/aluminum hydroxide, s.c.), followed by two intranasal ovalbumin challenges. From day 18 to day 22 after the first immunization, the mice receive daily gavages of Isoquercitrin (15 mg/kg) or quercetin (10 mg/kg). Dexamethasone (1 mg/kg, s. c.) is administered as a positive control. Leucocytes are analyzed in bronchoalveolar lavage fluid (BALF), blood and pulmonary parenchyma at 24 h after the last ovalbumin challenge. Interleukin-5 (IL-5) is analyzed in BALF and lung homogenates[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21.

    [2]. Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8.