Argipressin(Synonyms: 精氨加压素 Arg8-vasopressin AVP)

Argipressin;(Synonyms: 精氨加压素; Arg8-vasopressin; AVP) 纯度: 99.82%

Argipressin (Arg8-vasopressin) 可与血管精氨酸加压素受体 V1、V2 和 V3 结合,其在 A7r5 大鼠主动脉平滑肌细胞中对 V1 的 Kd 值为 1.31 nM。

Argipressinamp;;(Synonyms: 精氨加压素; Arg8-vasopressin;  AVP)

Argipressin Chemical Structure

CAS No. : 113-79-1

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10;mM;*;1 mL in Water ¥1181 In-stock
1 mg ¥500 In-stock
5 mg ¥800 In-stock
10 mg ¥990 In-stock
25 mg ¥1200 In-stock
50 mg ¥1600 In-stock
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生物活性

Argipressin (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.

体外研究
(In Vitro)

Argipressin binds to the vascular arginine vasopressin receptor, V1, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC50=5 nM)[1]. AVP-induced [Ca2+]i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca2+]i responses are 100 pM in non-neuronal cells in DRG culture[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

1084.23

Formula

C46H65N15O12S2

CAS 号

113-79-1

Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CYFQNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)

中文名称

精氨加压素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : ≥ 100 mg/mL (92.23 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9223 mL 4.6116 mL 9.2231 mL
5 mM 0.1845 mL 0.9223 mL 1.8446 mL
10 mM 0.0922 mL 0.4612 mL 0.9223 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56.

    [2]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.

    [3]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257.

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