WKYMVM

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WKYMVM; 纯度: 99.79%

WKYMVM 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂，同时可以激活一些白细胞效应功能，如趋化性、激活补体受体-3及 NADPH 氧化酶。

WKYMVMamp;;

WKYMVM Chemical Structure

CAS No. : 187986-17-0

规格 价格 是否有货 数量
5 mg ￥3600 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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WKYMVM 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Peptide Library

生物活性

WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2].

IC50 Target

FPR1, FPRL1[1], FPRL2[2]
分子量

856.11

Formula

C41H61N9O7S2
CAS 号

187986-17-0
Sequence

Trp-Lys-Tyr-Met-Val-{d-Met}-NH2
Sequence Shortening

WKYMV-{d-Met}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Protect from light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

H2O : 12.5 mg/mL (14.60 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1681 mL 5.8404 mL 11.6807 mL
5 mM 0.2336 mL 1.1681 mL 2.3361 mL
10 mM 0.1168 mL 0.5840 mL 1.1681 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93.

    [2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6.