Alisporivir;(Synonyms: Debio-025; DEB-025) 纯度: 98.15%
Alisporivir (Debio-025) 是亲环蛋白抑制剂,具有高效的抗丙型肝炎病毒 (HCV) 活性的。
Alisporivir Chemical Structure
CAS No. : 254435-95-5
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1 mg | ¥7000 | In-stock | |
5 mg | ¥21000 | In-stock | |
10 mg | ; | 询价 | ; |
50 mg | ; | 询价 | ; |
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Alisporivir 相关产品
bull;相关化合物库:
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Macrocyclic Compound Library
- Peptide Library
生物活性 |
Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity. |
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体外研究 (In Vitro) |
DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for HCV replication[1]. Alisporivir (Debio-025) represents the prototype of a new class of non-immunosuppressive cyclophilin inhibitors. Alisporivir prevents HCV protein-mediated collapse of the respiration-driven mitochondrial membrane potential. Alisporivir prevents HCV protein-mediated mitochondrial dysfunction outside the context of apoptosis, calcium overload, production of ROS, dysfunction[2]. In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication. Combination treatment with Alisporivir and ICN-1229 increases the anti-MERS-CoV activity in cell culture[3]. Alisporivir pretreatment stimulates antigen presentation by hepatoma target cells, leading to enhancement of antigen-specific CD8+ T cell activation by 40%. Alisporivir induces an increase of MHC-I and beta-2 microglobulin on the surface of several cell lines[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Combination treatment with Alisporivir and ICN-1229 does not protect against SARS-CoV infection in a mouse model[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
1216.64 |
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Formula |
C63H113N11O12 |
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CAS 号 |
254435-95-5 |
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中文名称 |
阿拉泊韦 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Stored under nitrogen
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen) |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 100 mg/mL (82.19 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [2] |
Alisporivir is prepared in DMSO at 4 mM and diluted in cell culture medium at the indicated concentrations (0.1, 0.2, 0.3, 0.4, 0.5 μM). UHCV-32 and UHCVcon-57.3 are U-2 OS human osteosar coma-derived cell lines inducibly expressing the entire open reading frame derived from the HCV H77 prototype and consensus clones, respectively. Cell viability is measured by trypan blue exclusion analysis[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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