Compstatin;(Synonyms: 坎普他汀) 纯度: 98.34%
Compstatin 是一个 13 残基环肽,是补体系统 C3 的有效抑制剂,具有物种特异性。Compstatin 结合到狒狒的 C3,并对狒狒血液中的蛋白水解裂解具有抗性 (类似人类)。Compstatin 只抑制灵长类补体系统的激活。Compstatin 对补体经典途径和旁路途径的 IC50 值分别为 63 μM 和 12 μM。
Compstatin Chemical Structure
CAS No. : 206645-99-0
规格 | 价格 | 是否有货 | 数量 |
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500 μg | ¥650 | In-stock | |
1 mg | ¥900 | In-stock | |
5 mg | ¥2200 | In-stock | |
10 mg | ; | 询价 | ; |
50 mg | ; | 询价 | ; |
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Compstatin 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Peptide Library
生物活性 |
Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4]. |
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体外研究 (In Vitro) |
Compstatin exhibits an in vitro half-life in human blood of about2 hr[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
1550.77 |
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Formula |
C66H99N23O17S2 |
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CAS 号 |
206645-99-0 |
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Sequence |
Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12) |
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Sequence Shortening |
ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12) |
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中文名称 |
坎普他汀 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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Solvent Solubility |
In Vitro:;
H2O Peptide Solubility and Storage Guidelines: 1.;;Calculate the length of the peptide. 2.;;Calculate the overall charge of the entire peptide according to the following table:
3.;;Recommended solution:
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参考文献 |
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