荧光染料Mito-TRFS

荧光染料Dye Reagents Mito-TRFS; 纯度: 95.75%

Mito-TRFS 是首个off-on 探针,可用于活细胞中线粒体硫氧还蛋白还原酶 (TrxR2) 的呈像。

Mito-TRFS

Mito-TRFS Chemical Structure

CAS No. : 1859102-62-7

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1 mg ¥2400 In-stock
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Mito-TRFS 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].

体外研究
(In Vitro)

Mito-TRFS (10 μM) has the maximal absorption at ~375 nm in TE buffer (50 mM Tris-HCl and 1 mM EDTA, pH 7.4) at 37 °C[1].
Mito-TRFS itself has a strong emission at ~480 nm when excited at 375 nm in TE buffer (φ=0.34), but has weak emission when excited at 438 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence[1].

Cell Line: HeLa cells.
Concentration: 1 μM.
Incubation Time: 2 h.
Result: Mito-TRFS is localized predominantly in the mitochondria of live cells.

分子量

820.70

Formula

C38H34IN2O5PS2

CAS 号

1859102-62-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Yaping Liu, et al. A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson’s disease model. Chem Commun (Camb). 2016 Feb 7;52(11):2296-9.

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