荧光染料PMQA(Synonyms: Zn-green)

发表于由

荧光染料Dye Reagents PMQA;(Synonyms: Zn-green)

PMQA (Zn-green) 是一种基于 8-aminoquinoline 的比率荧光传感器，显示了 Zn2+ 诱导的辐射红移 (85 nm)。PMQA (Zn-green) 是一种具有细胞膜通透性的荧光探针，适用于活细胞中的 Zn2+ 检测。

PMQA(Synonyms: Zn-green)

PMQA Chemical Structure

CAS No. : 1263820-18-3

规格 价格 是否有货
5 mg ￥2500 询问价格 货期
10 mg ￥4000 询问价格 货期

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生物活性

PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn2+-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn2+ in living cells[1].

体外研究
(In Vitro)

After incubation with PMQA (20 μM) for 1 h, weak green fluorescence appeared, presumably caused by the probe capturing intracellular zinc from its native ligands since PMQA has high affinity for zinc[1].
The response of PMQA to Zn2+ can be reversed by N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) or EDTA[1].
When the stock solution of PMQA (0.1 mM in Tris Buffer) is kept at room temperature for a week, there is no significant loss of PMQA determined by HPLC analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

292.34

Formula

C17H16N4O
CAS 号

1263820-18-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liangwei Zhang, et al. 8-Aminoquinoline-based ratiometric zinc probe: unexpected binding mode and its application in living cells. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3511-4.