PKA Inhibitor Fragment (6-22) amide TFA(Synonyms: PKI-(6-22)-amide TFA)

发表于由

PKA Inhibitor Fragment (6-22) amide TFA;(Synonyms: PKI-(6-22)-amide TFA) 纯度: 96.71%

PKA Inhibitor Fragment (6-22) amide TFA 是 cAMP 依赖性蛋白激酶 A (PKA) 的抑制剂，Ki 值为 2.8 nM。PKA Inhibitor Fragment (6-22) amide TFA 可显着逆转小鼠低水平的吗啡缓解疼痛的感受性。

PKA Inhibitor Fragment (6-22) amide TFAamp;;(Synonyms: PKI-(6-22)-amide TFA)

PKA Inhibitor Fragment (6-22) amide TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥2100 In-stock
10 mg ￥3500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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PKA Inhibitor Fragment (6-22) amide TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

PKA Inhibitor Fragment (6-22) amide TFA is an inhibitor of cAMP-dependent protein kinase A (PKA), with a Ki of 2.8 nM. PKA Inhibitor Fragment (6-22) amide TFA can significantly reverse low-level morphine antinociceptive tolerance in mice[1][2].

IC50 Target

PKA

2.8 nM (Ki)

分子量

1982.08

Formula

C82H131F3N28O26
Sequence Shortening

TYADFIASGRTGRRNAI-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 50 mg/mL (25.23 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5045 mL 2.5226 mL 5.0452 mL
5 mM 0.1009 mL 0.5045 mL 1.0090 mL
10 mM 0.0505 mL 0.2523 mL 0.5045 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Katz BM, et, al. Synthesis, characterization and inhibitory activities of (4-N3[3,5-3H]Phe10)PKI(6-22)amide and its precursors: photoaffinity labeling peptides for the active site of cyclic AMP-dependent protein kinase. Int J Pept Protein Res. 1989 Jun;33(6):439-45.

    [2]. Dalton GD, et, al. Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI). Neuropharmacology. 2005 Apr; 48(5): 648-57.