月度归档：2023年08月

Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden(Synonyms: Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside)

发表于由

天然产物 黄酮类 Flavonoids

Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden (Synonyms: Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside) 纯度: 98.97%

Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden 是来自于Quercetin 的一种黄酮。

Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden(Synonyms: Quercetin-3-O-beta-D-glucose-7-O-beta-D-gentiobioside)

Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden Chemical Structure

CAS No. : 60778-02-1

规格 价格 是否有货 数量
5 mg ￥2520 In-stock
10 mg ￥4290 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Phenols Library
  • Flavonoids Library

生物活性

Quercetin-3-O-β-D-glucose-7-O-β-D-gentiobiosiden is a flavonoid from Quercetin.

分子量

788.66

Formula

C33H40O22
CAS 号

60778-02-1
中文名称

槲皮素-3-O-β-D-葡萄糖-7-O-β-D-龙胆双糖苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (126.80 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2680 mL 6.3399 mL 12.6797 mL
5 mM 0.2536 mL 1.2680 mL 2.5359 mL
10 mM 0.1268 mL 0.6340 mL 1.2680 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 10 mg/mL (12.68 mM); Clear solution

    此方案可获得 ≥ 10 mg/mL (12.68 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 100.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 10 mg/mL (12.68 mM); Clear solution

    此方案可获得 ≥ 10 mg/mL (12.68 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 100.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

ILMVACYIQI141伊尔姆旋片泵PK/P-系列

发表于由
ILMVACYIQI141伊尔姆旋片泵PK/P-系列

ILMVAC YIQI141 伊尔姆旋片泵PK/P-系列

产品编号：
市场价：￥0.00元
会员价：￥0.00元
品牌：中文
生产厂家：ILMVAC
需求数量：

  • 产品概览
  • 技术参数
  • 订购信息
  • 相关资料
  • 相关产品

 

ilmvac YIQI141 伊尔姆旋片泵PK/P-系列

主要特点：
　　旋片泵PK/P-系列
　　- 结构紧凑，轻巧
　　- 噪音低，运行安静,不漏油
　　- 关机后密封性能好
　　- 流速高
　　- 短时间内达到稳定的极限真空
　　- 用弹性离合器直接驱动
　　- 结构坚固
　　- 保养间隔时间长
　　- 安装简单
　　- 适合于长时间运行

　　PS系列单级旋片泵：
　　最终压力为0.5mbar或1mbar，配有气配载阀。
　　PK系列和P系列二级旋片泵：
　　最终压力为2×10-3mbar的高真空。抽测试气体时可达到2×10-4 mbar，配有气压载阀。
　　特性：
　　压力油润滑
　　叶片和轴承在高压油下自动润滑。这样能改善最终真空，稳定泵的温度，延长泵和油的使用寿命。
　　液位显示窗：
　　最新的条形液位显示窗设计，能清楚地看清液位和真空油颜色的变化。
　　密封特性：
　　在PK/P旋片泵关机时，一个抽吸接口载阀阻止油回流而失去真空，也就是说，关机后的真空密封性能好。

  • key0：
  • key1：

    • 技术参数：
    　　型号 电压 最终压力mbar 抽吸速度 重量(kg) 编号

    　　PK2DC 230V 50Hz <1×10-2 1.830.0 8 302010
    　　PK4Dp 230V 50Hz <2×10-3 4.6 76.0 18 302099
    　　PK6Dp 230V 50Hz <2×10-3 5.8 96.0 20 302100
    　　PK8Dp 230V 50Hz <2×10-3 7.2 120.0 22 302101
    　　P12D 230V 50Hz <2×10-3 11.0 183.0 27 302313
    　　P17D 230V 50Hz <2×10-3 16.0 266.0 28.5 302074
    　　P23D 230V 50Hz <2×10-3 21.0 350.0 30 302390
    　　PS20 230V 50HZ <1.0 18.0 300.0 20 301861
    　　PS40 230V 50HZ <1.0 40.0 666.0 38 301862
    　　PS40 3×230/400V 50HZ <1.0 40.0 666.0 38 301852

    Scutellarin(Synonyms: 野黄芩苷)

    发表于由

    天然产物 黄酮类 Flavonoids

    Scutellarin (Synonyms: 野黄芩苷) 纯度: ≥98.0%

    Scutellarin 是从黄芩中分离到的黄酮类物质，在 HCC 细胞中，能够下调 STAT3/Girdin/Akt 信号通路，在破骨细胞中，能够抑制 RANKL 介导的 MAPK/NF-κB 信号通路。Scutellarin 具有抗 HIV-1IIIB，HIV-1(74V) 和 HIV-1KM018 的活性，EC50 分别为 26 μM，253 μM 和 136 μM。

    Scutellarin(Synonyms: 野黄芩苷)

    Scutellarin Chemical Structure

    CAS No. : 27740-01-8

    规格 价格 是否有货 数量
    10 mM * 1 mL in DMSO ￥500 In-stock
    10 mg ￥450 In-stock
    25 mg ￥780 In-stock
    50 mg ￥1400 In-stock
    100 mg   询价  
    200 mg   询价  

    * Please select Quantity before adding items.

    Scutellarin 相关产品

    •相关化合物库:

    • Natural Product Library Plus
    • Bioactive Compound Library Plus
    • Anti-Infection Compound Library
    • Immunology/Inflammation Compound Library
    • JAK/STAT Compound Library
    • Kinase Inhibitor Library
    • NF-κB Signaling Compound Library
    • PI3K/Akt/mTOR Compound Library
    • Stem Cell Signaling Compound Library
    • Natural Product Library
    • Anti-Cancer Compound Library
    • Antiviral Compound Library
    • Autophagy Compound Library
    • Small Molecule Immuno-Oncology Compound Library
    • Anti-Aging Compound Library
    • Differentiation Inducing Compound Library
    • Glycoside Compound Library
    • Oxygen Sensing Compound Library
    • Medicine Food Homology Compound Library
    • Phenols Library
    • Glycolysis Compound Library
    • Cytoskeleton Compound Library
    • Glutamine Metabolism Compound Library
    • Traditional Chinese Medicine Monomer Library
    • FDA Approved & Pharmacopeial Drug Library
    • Flavonoids Library
    • Neuroprotective Compound Library
    • Anti-Breast Cancer Compound Library
    • Anti-Lung Cancer Compound Library
    • Anti-Pancreatic Cancer Compound Library
    • Anti-Blood Cancer Compound Library
    • Anti-Cancer Metabolism Compound Library
    • Anti-Obesity Compound Library
    • Angiogenesis Related Compound Library
    • Transcription Factor Targeted Library
    • Glucose Metabolism Compound Library
    • Anti-Liver Cancer Compound Library
    • Anti-Colorectal Cancer Compound Library

    生物活性

    Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.

    IC50 & Target[1]

    STAT3

     

    Akt

     

    体外研究
    (In Vitro)

    Scutellarin treatment significantly reduces HepG2 cell viability in a dose-dependent manner, and inhibits migration and invasion of HCC cells in vitro. Scutellarin treatment significantly reduces STAT3 and Girders of actin filaments (Girdin) expression, STAT3 and Akt phosphorylation in HCC cells. Introduction of STAT3 overexpression restores the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells. Furthermore, induction of Girdin overexpression completely abrogates the inhibition of scutellarin on the Akt phosphorylation, migration and invasion of HCC cells. Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling[1]. Scutellarin selectively enhances Akt phosphorylation[2]. Scutellarin is a putative therapeutic agent as it has been found to not only suppress microglial activation thus ameliorating neuroinflammation, but also enhance astrocytic reaction. Acutellarin amplifies the astrocytic reaction by upregulating the expression of neurotrophic factors among others thus indicating its neuroprotective role. Remarkably, the effects of scutellarin on reactive astrocytes are mediated by activated microglia supporting a functional “cross-talk” between the two glial types[3]. Scutellarin can suppress RANKL-mediated osteoclastogenesis, the function of osteoclast bone resorption, and the expression levels of osteoclast-specific genes (tartrate-resistant acid phosphatase (TRAP), cathepsin K, c-Fos, NFATc1). Further investigation indicates that Scutellarin can inhibit RANKL-mediated MAPK and NF-κB signaling pathway, including JNK1/2, p38, ERK1/2, and IκBα phosphorylation[5].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Scutellarin (50 mg/kg/day) significantly mitigates the lung and intrahepatic metastasis of HCC tumors in vivo. The numbers of the lung and intrahepatic metastatic tumors in the scutellarin-treated group are significantly less than that in the controls[1]. The rats treated with Scutellarin display a significant alleviation in neurobehavioral deficits compared to the SAH group. Scutellarin enhanced eNOS expression compared with SAH rats[4].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    462.36

    Formula

    C21H18O12
    CAS 号

    27740-01-8
    中文名称

    野黄芩苷；野黄芩甙；灯盏花乙素；高黄芩苷；高黄芩甙；印黄芩苷；黃芹素
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (216.28 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.1628 mL 10.8141 mL 21.6282 mL
    5 mM 0.4326 mL 2.1628 mL 4.3256 mL
    10 mM 0.2163 mL 1.0814 mL 2.1628 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂： 0.5% CMC-Na/saline water

      Solubility: 10 mg/mL (21.63 mM); Suspended solution; Need ultrasonic

    *以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
    参考文献

    • [1]. Ke Y, et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X

      [2]. Yang LL, et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. Biochim Biophys Acta. 2016 Nov 27;1863(2):598-606.

      [3]. Wu CY, et al. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia – a therapeutic consideration. Curr Med Chem. 2016 Nov 18. [Epub ahead of print]

      [4]. Li Q, et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270

      [5]. Zhao S, et al. Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. Int Immunopharmacol. 2016 Nov;40:458-465

      [6]. Zhang GH, et al. The anti-HIV-1 effect of scutellarin. Biochem Biophys Res Commun. 2005 Sep 2;334(3):812-6.
    Cell Assay
    [1]

    HepG2 cells (1×105/well) are cultured in 96-well plates and treated in triplicate with scutellarin at concentrations of 5, 10, 20, 30, and 100 μM or vehicle alone for 24 h. The cellular viability is tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and is expressed as a percentage of proliferation versus controls.

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    To establish an orthotopic liver xenograft model, individual mice are anesthetized with isoflurane and a small incision is made in their abdomen. Individual mice are injected with 2×106 SK-Hep1 cells in 30 μL Matrigel into their left lobe of the liver. Twenty-four hours after orthotopic liver implantation, the mice are randomized and injected intraperitoneally with scutellarin (50 mg/kg/day) or vehicle (0.9% NaCl, normal saline) daily for 35 consecutive days (n=10 per group). Subsequently, the mice are sacrificed, and their lungs and livers are excised, fixed in 10% buffered formalin and paraffin-embedded for hematoxylin and eosin staining.

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    • [1]. Ke Y, et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochem Biophys Res Commun. 2016 Dec 18. pii: S0006-291X(16)32174-X

      [2]. Yang LL, et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. Biochim Biophys Acta. 2016 Nov 27;1863(2):598-606.

      [3]. Wu CY, et al. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia – a therapeutic consideration. Curr Med Chem. 2016 Nov 18. [Epub ahead of print]

      [4]. Li Q, et al. Scutellarin attenuates vasospasm through the Erk5-KLF2-eNOS pathway after subarachnoid hemorrhage in rats. J Clin Neurosci. 2016 Dec;34:264-270

      [5]. Zhao S, et al. Scutellarin inhibits RANKL-mediated osteoclastogenesis and titanium particle-induced osteolysis via suppression of NF-κB and MAPK signaling pathway. Int Immunopharmacol. 2016 Nov;40:458-465

      [6]. Zhang GH, et al. The anti-HIV-1 effect of scutellarin. Biochem Biophys Res Commun. 2005 Sep 2;334(3):812-6.

    Micheliolide(Synonyms: 木香内酯)

    发表于由

    上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

    Micheliolide (Synonyms: 木香内酯) 纯度: 99.84%

    Micheliolide能减弱高糖刺激的NF-κB活化，IκBα的降解，和MCP-1，TGF-β1，FN在鼠系膜细胞的表达。

    Micheliolide(Synonyms: 木香内酯)

    Micheliolide Chemical Structure

    CAS No. : 68370-47-8

    规格 价格 是否有货 数量
    10 mM * 1 mL in DMSO ￥3581 In-stock
    5 mg ￥3255 In-stock
    10 mg ￥4650 In-stock
    50 mg   询价  
    100 mg   询价  

    * Please select Quantity before adding items.

    Micheliolide 相关产品

    •相关化合物库:

    • Covalent Screening Library Plus
    • Natural Product Library Plus
    • Bioactive Compound Library Plus
    • Immunology/Inflammation Compound Library
    • NF-κB Signaling Compound Library
    • Stem Cell Signaling Compound Library
    • Natural Product Library
    • Anti-Aging Compound Library
    • Covalent Screening Library
    • Antioxidants Compound Library
    • Differentiation Inducing Compound Library
    • Oxygen Sensing Compound Library
    • Terpenoids Library
    • Pyroptosis Compound Library
    • Anti-Breast Cancer Compound Library
    • Anti-Pancreatic Cancer Compound Library
    • Anti-Blood Cancer Compound Library
    • Anti-Obesity Compound Library
    • Transcription Factor Targeted Library
    • Anti-Liver Cancer Compound Library

    生物活性

    Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

    分子量

    248.32

    Formula

    C15H20O3
    CAS 号

    68370-47-8
    中文名称

    木香内酯；乌心石内酯
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (402.71 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 4.0271 mL 20.1353 mL 40.2706 mL
    5 mM 0.8054 mL 4.0271 mL 8.0541 mL
    10 mM 0.4027 mL 2.0135 mL 4.0271 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (10.07 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (10.07 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
    • 3.

      请依序添加每种溶剂： 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (10.07 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

    *以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
    参考文献

    • [1]. Jia QQ, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013 Oct 21;18(10):13061-77.

    SHIMADZU岛津电子天平UX4200S

    发表于由
    SHIMADZU岛津电子天平UX4200S

    SHIMADZU岛津电子天平UX4200S

    产品编号：
    市场价：￥0.00元
    会员价：￥0.00元
    品牌：SHIMADZU 岛津
    生产厂家：SHIMADZU岛津
    需求数量：

    • 产品概览
    • 技术参数
    • 订购信息
    • 相关资料
    • 相关产品

    产品名称：SHIMADZU岛津电子天平UX4200S

    产品特点：

    n          采用独特UniBloc整体型传感器，超快稳定时间仅需0.7秒，灵敏度温度系数为3ppm
    n          高达1/620000的极限分辨率，最优性价比的精密电子天平
    n          直通视窗（Window)功能，仅需1根电缆线，即可联接电脑并传输数据
    n          带背灯LCD显示，便于照明不足环境下使用
    n          机内时钟，符合GLP/GMP/ISO要求
    n          比重测定功能
     
    产品功能：
    n          直通视窗功能
    n          机内时钟/ISO打印
    n          背灯
    n          外部砝码校正
     

    技术参数：

    产品型号
    UX4200S(321-62350-09)
    称量能力
    4200g
    最小显示值
    0.1g
    重复性
    0.08g
    线性
    0.1g
    平均响应时间
    0.7-1.2s
    称量盘尺寸
    约170×180mm
    耗电量
    12VA以下
    接口
    RS-232接口；DATA I/O接口
    其他
    内置Windows直视窗；塑料保护罩；模拟显示图形；称勾下悬挂测量

    sartorius醋酸纤维素膜11106-047N 11106-047N

    发表于由

    sartorius醋酸纤维素膜11106-047N

    德国sartorius醋酸纤维素膜11106-047N,直径47mm,孔径：0.45um,100片/盒。 德国sartorius醋酸纤维素膜11106-047N为圆片膜直径从13-293mm共10个规格可供选择。

     

     德国sartorius醋酸纤维素膜11106-47N的特点：流速高，热稳定性强，吸附低。因此0.2um的醋纤膜是水相溶液如缓冲液，血清，培养基chu菌过滤的理想用膜,0.45um也适用于溶液的澄清过滤。


    技术规格
    材料 醋酸纤维素 (CA)
    厚度 135µm (平均值)
    泡点(水) 0.2µm：3.5bar 0.45µm：2.0bar
    0.65µm：1.3bar 0.8µm：0.8bar
    化学兼容性 耐水相溶液，pH4-8范围内稳定，可耐受大多数醇类和油类，详情参见化学兼容性表
    溶出物 水，<1%
    流速(水)
    Δp100 kPa 0.2µm：22ml/分/cm2 0.45µm：69ml/分/cm2
    0.65µm：130ml/分/cm2 0.8µm：200ml/分/cm2
    热稳定性 zui高温度180℃
    mie菌方式 高压mie菌(121℃或134℃)，干热**(180℃)，γ-射线或环氧乙烷熏蒸
    验证 0.2µm滤膜的泡点值，经过标准xi菌挑战试验验证，以保证chu菌过滤的可靠性。

    Atractylenolide I(Synonyms: 白术内酯 I)

    发表于由

    上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

    Atractylenolide I (Synonyms: 白术内酯 I) 纯度: 99.83%

    Atractylenolide I 是从白术根中得到的倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。Atractylenolide I 为 TLR4 的拮抗剂，同时在 A375 细胞中，能够降低 JAK2 和 STAT3 的磷酸化水平。

    Atractylenolide I(Synonyms: 白术内酯 I)

    Atractylenolide I Chemical Structure

    CAS No. : 73069-13-3

    规格 价格 是否有货 数量
    10 mM * 1 mL in DMSO ￥990 In-stock
    5 mg ￥900 In-stock
    10 mg ￥1500 In-stock
    50 mg ￥4900 In-stock
    100 mg   询价  
    200 mg   询价  

    * Please select Quantity before adding items.

    Atractylenolide I 相关产品

    •相关化合物库:

    • Natural Product Library Plus
    • Bioactive Compound Library Plus
    • Epigenetics Compound Library
    • Immunology/Inflammation Compound Library
    • JAK/STAT Compound Library
    • Kinase Inhibitor Library
    • Stem Cell Signaling Compound Library
    • Natural Product Library
    • Anti-Cancer Compound Library
    • Small Molecule Immuno-Oncology Compound Library
    • Anti-Aging Compound Library
    • Antioxidants Compound Library
    • Oxygen Sensing Compound Library
    • Terpenoids Library
    • Pyroptosis Compound Library
    • Traditional Chinese Medicine Monomer Library
    • Neuroprotective Compound Library
    • Anti-Lung Cancer Compound Library
    • Anti-Pancreatic Cancer Compound Library
    • Transcription Factor Targeted Library

    生物活性

    Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.

    IC50 & Target

    JAK2, STAT3[1], TLR4[4]
    体外研究
    (In Vitro)

    Atractylenolide I (40, 60, 80, 100, 120, 150 μM) dose- and time-dependently reduces the cell viability in human A375 melanoma cells after treatment for 24, 48 and 72 hours. Atractylenolide I (50 and 100 μM) induces apoptosis of A375 cells in a dose-dependent manner at 48 h of treatment. Atractylenolide I (100 μM) significantly reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, without effect on total JAK2 and STAT3. Furthermore, Atractylenolide I inhibits the mRNA expression of STAT3-targeted genes, including Bcl-xL, MMP-2 and MMP-9[1]. Atractylenolide I (up to 100 μM) shows no toxicity in normal cells. Atractylenolide I (25, 50 μM) decreases the Ox-LDL induced TNF-α, IL-6 and NO production in VSMCs. Atractylenolide I (12.5, 25 or 50 μM) significantly reduces the level of MCP-1 and inhibits Ox-LDL-induced VSMCs proliferation and migration. Atractylenolide I (25, 50 μM) inhibits positive staining of foam cells, and also significantly decreases lipid accumulation. Atractylenolide I (50 μM) suppresses p38MAPK and NF-κB p65 expression in VSMCs stimulated by Ox-LDL[3]. Atractylenolide I (1, 10, 100 μM) downregulates paclitaxel-induced expression of VEGF and survivin via MyD88-dependent TLR4 signaling in EOC cells[4].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Atractylenolide I (5, 10 or 20 mg/kg, p.o.) restores the decreased body weight in mice subjected to chronic unpredictable mild stress (CUMS). Atractylenolide I alleviates CUMS-induced depressive-like behavior, attenuates CUMS-induced imbalances in hippocampal neurotransmitter levels and reduces CUMS-induced increases in hippocampal pro-inflammatory cytokine levels and in the NLRP3 inflammasome in the hippocampi of mice[2].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    230.30

    Formula

    C15H18O2
    CAS 号

    73069-13-3
    中文名称

    白术内酯 I
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (434.22 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 4.3422 mL 21.7108 mL 43.4216 mL
    5 mM 0.8684 mL 4.3422 mL 8.6843 mL
    10 mM 0.4342 mL 2.1711 mL 4.3422 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.86 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (10.86 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.86 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (10.86 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
    • 3.

      请依序添加每种溶剂： 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.86 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (10.86 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

    *以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
    参考文献

    • [1]. Atractylenolide I, et al. The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I. Exp Dermatol. 2018 Feb;27(2):201-204.

      [2]. Gao H, et al. Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Exp Ther Med. 2018 Feb;15(2):1574-1579.

      [3]. Li W, et al. Atractylenolide I restores HO-1 expression and inhibits Ox-LDL-induced VSMCs proliferation, migration and inflammatory responses in vitro. Exp Cell Res. 2017 Apr 1;353(1):26-34.

      [4]. Huang JM, et al. Atractylenolide-I sensitizes human ovarian cancer cells to paclitaxel by blocking activation of TLR4/MyD88-dependent pathway. Sci Rep. 2014 Jan 23;4:3840.
    Cell Assay
    [3]

    Briefly, serum starved VSMCs are pre-treated with indicated concentration of Atractylenolide I for 1 h followed by stimulation with Ox-LDL for 24 h. The purple formazan crystals formed after addition of MTT are solubilized in DMSO and absorbance is measured at 540 nm. The viability or proliferation rate is calculated as percentage of control (untreated VSMCs)[3].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Mice[2]
    After adaption for one week, 48 male ICR mice are randomly divided into six groups (eight mice per group): Control group (unstressed + saline vehicle), model group (CUMS + saline vehicle), three Atractylenolide I treatment groups (CUMS + Atractylenolide I) and a fluoxetine group (CUMS + FLU). From the 4th week, Atractylenolide I (5, 10 or 20 mg/kg) or fluoxetine (20 mg/kg) is daily administered by oral gavage for 3 weeks. After the last administration of Atractylenolide I or fluoxetine, behavioral tests are performed[2].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    • [1]. Atractylenolide I, et al. The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I. Exp Dermatol. 2018 Feb;27(2):201-204.

      [2]. Gao H, et al. Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Exp Ther Med. 2018 Feb;15(2):1574-1579.

      [3]. Li W, et al. Atractylenolide I restores HO-1 expression and inhibits Ox-LDL-induced VSMCs proliferation, migration and inflammatory responses in vitro. Exp Cell Res. 2017 Apr 1;353(1):26-34.

      [4]. Huang JM, et al. Atractylenolide-I sensitizes human ovarian cancer cells to paclitaxel by blocking activation of TLR4/MyD88-dependent pathway. Sci Rep. 2014 Jan 23;4:3840.

    Chamaechromone(Synonyms: 狼毒色酮；狼毒色原酮)

    发表于由

    天然产物 黄酮类 Flavonoids

    Chamaechromone (Synonyms: 狼毒色酮；狼毒色原酮)

    Chamaechromone 是从百里香科植物的根中分离得到的一种双黄酮成分。Chamaechromone 具有抗乙型肝炎病毒 (HBV) 作用，抑制乙肝病毒的表面分泌抗原 (HBsAg)，并具有杀虫活性。

    Chamaechromone(Synonyms: 狼毒色酮；狼毒色原酮)

    Chamaechromone Chemical Structure

    CAS No. : 93413-00-4

    规格 是否有货
    1 mg 询价

    * Please select Quantity before adding items.

    生物活性

    Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses anti-hepatitis B virus (HBV) effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities[1].

    分子量

    542.49

    Formula

    C30H22O10
    CAS 号

    93413-00-4
    中文名称

    狼毒色酮；狼毒色原酮
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Yan Lou, et al.Metabolites characterization of chamaechromone in vivo and in vitro by using ultra-performance liquid chromatography/Xevo G2 quadrupole time-of-flight tandem mass spectrometry. J Ethnopharmacol

    15950-017-颇尔PALL颇尔20ml血清替代物

    发表于由
    • 型号 15950-017
    • 品牌 PALL颇尔
    • 【简单介绍】

      颇尔PALL颇尔20ml血清替代物 PALL 15950-017 血清替代品可以在细胞培养基中成功替代FBS（胎牛血清），可用于依赖贴壁细胞的体外培养，并通过一系列质量测试，包括PH、蛋白质浓度、无菌控制、细菌和真菌、牛病毒（BHV1-DVB/MM,红细胞吸附）、支原体、Hep G2细胞增殖能力、核型分析等。
      温馨提示：不可用于临床治疗。

      颇尔PALL颇尔20ml血清替代物 15950-017

      PALL 15950-017 血清替代品简介：
      PALL 15950-017 血清替代品可以在细胞培养基中成功替代FBS(胎牛血清)，可用于依赖贴壁细胞的体外培养，并通过一系列质量测试，包括PH、蛋白质浓度、无菌控制、细菌和真菌、牛病毒（BHV1-DVB/MM,红细胞吸附）、支原体、Hep G2细胞增殖能力、核型分析等。
      温馨提示：不可用于临床治疗。

      产品标签：一款众星捧月，风靡的新型血清替代物！！！

       市场需求背景

      1）血清原料吃紧，进口卡死，断货频繁，有市无货问题严重。

      2）血清成分不稳定，批次之间差异明显，导致以动物细胞培养为基础的生产无法精zhun控制产量和成本。

      3）血清运输要求极为严格（干冰运输），引发很多不便利性。
       

      正是在以上的市场需求背景下，一款原料成本低，原料来源广泛不受限；组分清晰，批次间稳定性和重复性高的产品；报关手续简单，无限制成分；运输要求低（室温或冰袋运输），保存周期长的产品被*科研人员所期盼。无血清细胞培养在技术上已是必不可挡的趋势。Pall Corporation的Ultroser™ Serum Substitute 血清替代物正是这股风潮中，走在前端的产品，在全美、欧洲、亚洲受到各大实验室和制药公司的推崇，25年生产和销售历史，上千篇应用文献，魅力无极限。

       

      产品描述：

      Ultroser™ G Serum Substitute（血清替代物）能够*替代细胞培养中的新生牛/胎牛血清（Fetal calf serum，FCS），特别开发用作体外培养贴壁依赖性细胞，特别测试用作羊水细胞的原代培养以及染色体核型分析，使用意义重大。

      Ultroser™ G Serum Substitute（血清替代物）是CE认证产品（CE mark-certified.）。

       

      产品优势：

      1）半定义组分，含6类真核细胞生长所必须的营养物质，包括粘附因子、结合蛋白、生长因子、微量元素、激素、维生素等，确保批次-批次间的稳定性和可重复性；

      2）蛋白内容含量低；

      3）冻干粉形式，只需室温运输，运输成本低且方便；

      4）2-8℃保存，稳定性高，从生产日期算起，4年效期；

      5）与新生牛/胎牛血清（FCS）相比，生物活性是血清的5倍。基础培养基内添加2%Ultroser™ G Serum Substitute（血清替代物）足以替代10% FCS。

      6）生产工艺先进，多项质控指标，绝不含糊；

           质量控制参数：

           a，物化指标包括pH，蛋白浓度，无菌控制，细菌&真菌，牛来源病毒（BHV1-DVB/MM, hemadsorbents），支原体；

           b，HepG2细胞的增殖能力检测；

           c，染色体核型分析；

       

      产品应用【示例】：

      以下是使用Ultroser™ G Serum Substitute（血清替代物）成功培养的细胞：

      Glial cells，Thyroid cells，Chondrocytes，Arterial cells，Leydig cells，Lewis cells

      Rat myocytes，Human myocytes，Amniotic cells，Vero，CHO，BHK

      Bone marrow cells，Fibroblasts skin cells，Chicken fibroblasts，HeLa，MRC-5，Promyelocytes HL60

      Raji，P3HR1，Astrocytes，Erythoblastes，Hypothalamic cells，Keratinocytes

      颇尔PALL颇尔20ml血清替代物 15950-017

      15950-017-颇尔PALL颇尔20ml血清替代物

      注意事项

      为了您的安全和健康，请穿实验服并戴一次性手套操作。

      本产品仅能用作科研用途，不可他用。