日度归档：2023年8月24日

Bakuchiol(Synonyms: 补骨脂酚; (S)-(+)-Bakuchiol)

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Bakuchiol (Synonyms: 补骨脂酚; (S)-(+)-Bakuchiol) 纯度: 98.13%

补骨脂酚(Bakuchiol)是一种从补骨脂种子中植物雌激素，具有抗肿瘤等作用。

Bakuchiol(Synonyms: 补骨脂酚; (S)-(+)-Bakuchiol)

Bakuchiol Chemical Structure

CAS No. : 10309-37-2

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥880 In-stock
5 mg ￥800 In-stock
10 mg ￥1200 In-stock
25 mg ￥2500 In-stock
50 mg ￥4000 In-stock
100 mg ￥6400 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Bakuchiol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Kinase Inhibitor Library
  • MAPK Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Clinical Compound Library
  • Autophagy Compound Library
  • Drug Repurposing Compound Library
  • Reprogramming Compound Library
  • Lipid Compound Library
  • Oxygen Sensing Compound Library
  • Terpenoids Library
  • Phenols Library
  • Pyroptosis Compound Library
  • Anti-Lung Cancer Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Angiogenesis Related Compound Library

生物活性

Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L; has anti-tumor effects. IC50 value: Target: in vitro: Bakuchiol reduced mitochondrial membrane potential (Psim) of cells in a concentration- and time-dependent manner, showing a more potent effect than that of resveratrol. S phase arrest, caspase 9/3 activaton, p53 and Bax up-regulation, as well as Bcl-2 down-regulation were observed in bakuchiol-treated A549 cells [1]. UGT2B7 was inhibited by the strongest intensity. The noncompetitive inhibition was demonstrated by the results obtained from Dixon plot and Lineweaver-Burk plot. The Ki value was calculated to be 10.7 μM [2]. Bakuchiol was found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62μM to 3.89μM [3]. After exposure to bakuchiol at 0.25-fold, 0.5-fold and 1-fold of minimum inhibitory concentration (MIC) (3.91 μg/ml) for 24h, the fungal conidia of T. mentagrophytes demonstrated a significant dose-dependent increase in membrane permeability. Moreover, bakuchiol at 1-fold MIC elicited a 187% elevation in reactive oxygen species (ROS) level in fungal cells after a 3-h incubation [4]. in vivo: In combination with the reported concentration after an intravenous administration of bakuchiol (15 mg/kg) in rats, the high risk of in vivo inhibition of bakuchiol towards UGT2B7-catalyzed metabolism of drugs was indicated [2]. In a guinea pig model of tinea pedis, bakuchiol at 1%, 5% or 10% (w/w) concentration in aqueous cream could significantly reduce the fungal burden of infected feet (p<0.01-0.05) [4].

Clinical Trial

分子量

256.38

Formula

C18H24O
CAS 号

10309-37-2
中文名称

补骨脂酚
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL (243.78 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9005 mL 19.5023 mL 39.0046 mL
5 mM 0.7801 mL 3.9005 mL 7.8009 mL
10 mM 0.3900 mL 1.9502 mL 3.9005 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (8.46 mM); Clear solution

    此方案可获得 ≥ 2.17 mg/mL (8.46 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 21.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (8.46 mM); Clear solution

    此方案可获得 ≥ 2.17 mg/mL (8.46 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 21.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Chen Z, et al. Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol. 2010 Sep 25;643(2-3):170-9.

    [2]. Xu Y, et al. In vitro evidence for bakuchiol’s influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr Health Sci. 2014 Sep;14(3):564-9.

    [3]. Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106.

    [4]. Lau KM, et al. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine. 2014 Jun 15;21(7):942-5.

荧光染料HBC525

发表于由

荧光染料Dye Reagents HBC525;

HBC525 是一种类 HBC 荧光团和荧光 RNA 适体 (Kd=3.8 nM)。HBC525 可以直接作为融合标签用于感兴趣的细胞 RNA 的成像和跟踪。荧光 RNA 适体也被用于构建各种有趣的用于细胞靶点检测和成像的动态 RNA 纳米工具。

HBC525

HBC525 Chemical Structure

CAS No. : 2174014-64-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

HBC525 is a HBC-like fluorophore and a fluorogenic RNA aptamer (Kd=3.8 nM). HBC525 can be directly used as fusion tags for the imaging and tracking of cellular RNAs of interest. Fluorogenic RNA aptamers have also been used to construct various interesting dynamic RNA nanodevices for cellular target detection and imaging[1][2].

IC50 Target

HBC525: 491/525 nm (Ex/Em)[2]
体内研究
(In Vivo)

荧光RNA适体

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

319.36

Formula

C19H17N3O2
CAS 号

2174014-64-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chen X, et al. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol. 2019;37(11):1287-1293.

    [2]. Yu Q, et al. Genetically encoded RNA nanodevices for cellular imaging and regulation. Nanoscale. 2021;13(17):7988-8003.

Epimedin B(Synonyms: 朝藿定 B；淫羊霍定 B；淫羊藿苷 B；淫羊藿定 B)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Epimedin B (Synonyms: 朝藿定 B；淫羊霍定 B；淫羊藿苷 B；淫羊藿定 B) 纯度: 99.90%

朝藿定B (Epimedin B)是淫羊藿中的一种天然活性成分，据报道有抗骨质疏松症的潜能。

Epimedin B(Synonyms: 朝藿定 B；淫羊霍定 B；淫羊藿苷 B；淫羊藿定 B)

Epimedin B Chemical Structure

CAS No. : 110623-73-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1020 In-stock
5 mg ￥680 In-stock
10 mg ￥1150 In-stock
50 mg ￥4160 In-stock
100 mg ￥5490 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Epimedin B 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Natural Product Library
  • Glycoside Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library

生物活性

Epimedin B, a component extracted from Epimedii Folium, is reported to have antiosteoporotic activity. IC50 value: Target: In vitro: In vivo: Prednisolone-induced osteoporosis model using zebrafish was used to evaluate the antiosteoporotic activity of micro amount epimedin B. The result showed that 1 μmol·L- 1epimedin B groups were significantly increased when compared with model group; Epimedin B can prevent zebrafish osteoporosis induced by prednisolone [1].

分子量

808.78

Formula

C38H48O19
CAS 号

110623-73-9
中文名称

朝藿定 B；淫羊霍定 B；淫羊藿苷 B；淫羊藿定 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (123.64 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2364 mL 6.1822 mL 12.3643 mL
5 mM 0.2473 mL 1.2364 mL 2.4729 mL
10 mM 0.1236 mL 0.6182 mL 1.2364 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.03 mM); Clear solution

    此方案可获得 ≥ 0.83 mg/mL (1.03 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (1.03 mM); Clear solution

    此方案可获得 ≥ 0.83 mg/mL (1.03 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. ZHAN Yang, et al. Evaluation of Antiosteoporotic Activity for Micro Amount Icariin and Epimedin B Based on the Osteoporosis Model Using Zebrafish. Chinese Pharmaceutical Journal, 2014-01

    [2]. Cui L, et al. Metabolite profiles of epimedin B in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J Agric Food Chem. 2013 Apr 17;61(15):3589-99.

    [3]. ZHANG Hua-feng, et al. Effects of microwave radiation on extraction of epimedin B from Epimedii Folium. Chinese Traditional and Herbal Drugs, 2011-09

WATSON 滤芯吸头126-20S 126-20S

发表于由

WATSON 滤芯吸头126-20S

WATSON 滤芯吸头126-20S 替换型 WATSON 滤芯吸头126-20S 20μl带滤芯吸头

WATSON 滤芯吸头126-20S

替换型

20μl带滤芯吸头

96支/盘 10盘/内箱 5内箱/外箱   已mie菌

货号

品名 规格
110-204C 10μl白吸头 1000支/包 20包/箱
110-505C 300μl白吸头 1000支/包 30包/箱
110-705Y 200μl带刻度黄吸头 1000支/包 40包/箱
110-804B 1000μl蓝吸头 带刻度 1000支/包 10包/箱
110-805C 1200μl白吸头 带刻度 1000支/包 10包/箱
120-801CS 250μl加长白吸头 96支/盒 50盒/箱
120-805cs 1200μl白吸头 带刻度 96支/盒 50盒/箱
124-1200S 1200μl加长型盒装带滤芯吸头 96支/盒 50盒/箱
124-20S 20μl带滤芯吸头 96支/盒 50盒/箱
124-10S 10μl滤芯吸头 96支/盒 50盒/箱
1252-703cs 200μl带滤芯吸头 96支/盒 50盒/箱
1252-801CS 200μl加长型盒装带滤芯吸头

96支/盘 10盘/内箱 5内箱/外箱

1272-801cs 200ul加长型盒装带滤芯吸头 已mie菌 96支/盘 10盘/内箱 5内箱/外箱
126-10S 10μl加长带滤芯吸头 96支/盘 50盘/

Corylin(Synonyms: 补骨脂异黄酮)

发表于由

天然产物 黄酮类 Flavonoids

Corylin (Synonyms: 补骨脂异黄酮) 纯度: 99.66%

Corylin是一种重要的生物活性化合物从补骨脂中分离；抗生素或抗癌化合物。

Corylin(Synonyms: 补骨脂异黄酮)

Corylin Chemical Structure

CAS No. : 53947-92-5

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥880 In-stock
5 mg ￥800 In-stock
10 mg ￥1100 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Corylin 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Lipid Compound Library
  • Antibacterial Compound Library
  • Phenols Library
  • Antibiotics Library
  • Flavonoids Library

生物活性

Corylin is a major bioactive compound isolated from Psoralea corylifolia L; antibiotic or anticancer compound. IC50 value: Target: in vitro: Corylin showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 1.37 uM [1].

分子量

320.34

Formula

C20H16O4
CAS 号

53947-92-5
中文名称

补骨脂宁；补骨脂异黄酮；榛仁球蛋白
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (312.17 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1217 mL 15.6084 mL 31.2168 mL
5 mM 0.6243 mL 3.1217 mL 6.2434 mL
10 mM 0.3122 mL 1.5608 mL 3.1217 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (9.37 mM); Clear solution

    此方案可获得 ≥ 3 mg/mL (9.37 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78(9):903-6.

3X FLAG peptide TFA

发表于由

3X FLAG peptide TFA; 纯度: 99.79%

3X FLAG peptide TFA 是一种合成的多肽，包含三个重复的 Asp-Tyr-Lys-Xaa-Xaa-Asp 基序。

3X FLAG peptide TFAamp;;

3X FLAG peptide TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥600 In-stock
5 mg ￥1200 In-stock
10 mg ￥2100 In-stock
25 mg ￥4200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

3X FLAG peptide TFA is a synthetic peptide with a 3-time repeated DYKXXD motif[1].

体外研究
(In Vitro)

3X FLAG peptide can be used to label protein and other molecules.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2975.84

Formula

C122H170F3N31O51S
Sequence

Met-Asp-Tyr-Lys-Asp-His-Asp-Gly-Asp-Tyr-Lys-Asp-His-Asp-Ile-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys
Sequence Shortening

MDYKDHDGDYKDHDIDYKDDDDK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 25 mg/mL (8.40 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3360 mL 1.6802 mL 3.3604 mL
5 mM 0.0672 mL 0.3360 mL 0.6721 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;PBS

    Solubility: 50 mg/mL (16.80 mM); Clear solution; Need ultrasonic and adjust pH to 3 with HCl

  • 2.

    请依序添加每种溶剂：;20 mM Tris pH7.5, 100 mM NaCl

    Solubility: 33.33 mg/mL (11.20 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Zilio N, et al. Improved Tandem Affinity Purification Tag and Methods for Isolation of Proteins and Protein Complexes from Schizosaccharomyces pombe. Cold Spring Harb Protoc. 2017 Mar 1;2017(3):pdb.prot091611.

荧光染料IDT307

发表于由

荧光染料Dye Reagents IDT307; 纯度: 99.10%

IDT307 是有机阳离子 MPP+ 的类似物，是 DAT 的荧光底物 (荧光底物 APP+)。

IDT307amp;;

IDT307 Chemical Structure

CAS No. : 1141-41-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
5 mg ￥500 In-stock
10 mg ￥800 In-stock
25 mg ￥1500 In-stock
50 mg ￥2500 In-stock
100 mg ￥4000 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

IDT307 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1].

体外研究
(In Vitro)

IDT307, an analog of the organic cation MPP+, is transported into CP epithelial cells at the apical (CSF-facing) membrane and sensitive to inhibition by the PMAT inhibitor quinine[1].
IDT307 uptake and intracellular accumulation is greatly attenuated by ~70% in CP tissue from the Pmat knockout mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.20

Formula

C14H17IN2
CAS 号

1141-41-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 62.5 mg/mL (183.72 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9394 mL 14.6972 mL 29.3945 mL
5 mM 0.5879 mL 2.9394 mL 5.8789 mL
10 mM 0.2939 mL 1.4697 mL 2.9394 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.11 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.11 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.11 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Tao Hu, et al. Molecular mechanisms of organic cation and anion transport at the blood‐CSF barrier. 01 April 2018.

Pseudohypericin(Synonyms: 伪金丝桃素)

发表于由

天然产物醌类Quinones

Pseudohypericin (Synonyms: 伪金丝桃素) 纯度: ≥95.0%

Pseudohypericin 及其同系物 Hypericin 是金丝桃属植物中主要的羟基菲咯啉酮类化合物。Pseudohypericin 具有抗 HIV 病毒活性。

Pseudohypericin(Synonyms: 伪金丝桃素)

Pseudohypericin Chemical Structure

CAS No. : 55954-61-5

规格 价格 是否有货 数量
1 mg ￥3050 In-stock
5 mg ￥9140 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

Pseudohypericin and its congener Hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Pseudohypericin shows anti-HIV activity[1][2].

体外研究
(In Vitro)

Pseudohypericin shows antiretroviral activity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

520.44

Formula

C30H16O9
CAS 号

55954-61-5
中文名称

伪金丝桃素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Lavie G, et al. Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5963-7.

    [2]. Zheng X, et al. Apoptosis of THP-1 Macrophages Induced by Pseudohypericin-Mediated Sonodynamic Therapy Through the Mitochondria-Caspase Pathway. Cell Physiol Biochem. 2016;38(2):545-57.

Incensole Acetate

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Incensole Acetate  纯度: 99.08%

Incensole acetate是卡氏乳香树脂的主要成分，对创伤性和缺血性颅脑损伤中的神经元损伤具有神经保护作用。Incensole acetate 减少了 hOBNSC 中由 Aβ 25-35 触发的细胞凋亡(apoptosis)。

Incensole Acetate

Incensole Acetate Chemical Structure

CAS No. : 34701-53-6

规格 价格 是否有货 数量
5 mg ￥1340 In-stock
10 mg ￥2290 In-stock
25 mg ￥4570 In-stock
50 mg ￥6860 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Incensole Acetate 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Covalent Screening Library
  • Terpenoids Library
  • Neuroprotective Compound Library

生物活性

Incensole acetate is a main constituent of Boswellia carterii resin, has neuroprotective effects against neuronal damage in traumatic and ischemic head injury. Incensole acetate reduces Aβ25–35-triggered apoptosis in hOBNSCs[1].

体外研究
(In Vitro)

Incensole acetate (100 μM; pre-treatment 4 hours) significantly ameliorates Aβ 25–35-induced cell death, a 48–52% decrease in cell viability at Aβ25–35 is restored to 85–89% upon pre-treatment with IA[1].
Incensole acetate (5-100 μM) pretreatment reverses increase in the mRNA and protein level of Bax, caspase 8, cyto c and decrease in the mRNA and protein level of Bcl2 induced by Aβ 25–35 in hOBNSCs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human olfactory bulb neural stem cells
Concentration: 100 μM
Incubation Time: Pre-treatment 4 hours
Result: Increased hOBNSCs cell viability induced by Aβ 25-35.

分子量

348.52

Formula

C22H36O3
CAS 号

34701-53-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (286.93 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8693 mL 14.3464 mL 28.6928 mL
5 mM 0.5739 mL 2.8693 mL 5.7386 mL
10 mM 0.2869 mL 1.4346 mL 2.8693 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.17 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.17 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (7.17 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (7.17 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. El-Magd MA, et al. Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells. Biomed Pharmacother. 2018 Sep;105:813-823.

Gelucire 44/14(Synonyms: 月桂酸聚乙二醇甘油酯)

发表于由

生化分析试剂 Biochemical Assay Reagents
Gelucire 44/14;(Synonyms: 月桂酸聚乙二醇甘油酯) 纯度: ge;96.0%

Gelucire 44/14 是一种强效且安全的吸收促进剂，用于改善通过肺部递送的难吸收药物的吸收包括胰岛素和降钙素在内。

Gelucire 44/14(Synonyms: 月桂酸聚乙二醇甘油酯)

Gelucire 44/14 Chemical Structure

CAS No. : 121548-04-7

规格 价格 是否有货 数量
25 g ￥500 In-stock
50 g ￥800 In-stock
100 g ￥1300 In-stock
> 100 g ; 询价 ;

* Please select Quantity before adding items.

生物活性

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery.

体内研究
(In Vivo)

Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable drugs including insulin and calcitonin by pulmonary delivery. It is found that pulmonary absorptions of FD4, FD10 and FD70 are enhanced in different degree by Gelucire 44/14 in a concentration-dependent manner, and the maximal absorption-enhancing effect is obtained when the concentration of Gelucire 44/14 reaches to 2.0% (w/v). It is also found that the absorption enhancing ability of Gelucire Gelucire 44/14 is correlated with the molecular weight of model drugs, and the highest absorption enhancement ratio of Gelucire Gelucire 14/44 is observed when the molecular weight of model drugs reaches to nearly 10000 Da[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号

121548-04-7
中文名称

月桂酸聚乙二醇甘油酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20deg;C 3 years
4deg;C 2 years
溶解性数据
In Vitro:;

Ethanol : 50 mg/mL (Need ultrasonic)
参考文献

  • [1]. Zhang H, et al. Improvement of pulmonary absorptions of poorly absorbable drugs using Gelucire 44/14 as an absorption enhancer. J Pharm Pharmacol. 2014 Oct;66(10):1410-20.
Animal Administration
[1]

Male Sprague Dawley rats are used to evaluate the pulmonary membrane toxicity of Gelucire 44/14. PBS (pH 7.4) with or without Gelucire 44/14 are directly administered to the tracheae of the rats according to the in-situ pulmonary absorption experiments. Four hours later, the rats are bled from the abdominal aorta, and then PBS (pH7.4) is perfused into the rat lung along the trachea. Afterwards, bronchoalveolar lavage fluid (BALF) of rat in each group is collected and kept in ice immediately until determination[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Zhang H, et al. Improvement of pulmonary absorptions of poorly absorbable drugs using Gelucire 44/14 as an absorption enhancer. J Pharm Pharmacol. 2014 Oct;66(10):1410-20.