Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression[1].
分子量
306.48
Formula
C20H34O2
CAS 号
22419-74-5
中文名称
因香酚
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Al-Harrasi A, et al. Distribution of the anti-inflammatory and anti-depressant compounds: Incensole and incensole acetate in genus Boswellia. Phytochemistry. 2019 May;161:28-40.
Incensole acetate is a main constituent of Boswellia carterii resin, has neuroprotective effects against neuronal damage in traumatic and ischemic head injury. Incensole acetate reduces Aβ25–35-triggered apoptosis in hOBNSCs[1].
体外研究 (In Vitro)
Incensole acetate (100 μM; pre-treatment 4 hours) significantly ameliorates Aβ 25–35-induced cell death, a 48–52% decrease in cell viability at Aβ25–35 is restored to 85–89% upon pre-treatment with IA[1]. Incensole acetate (5-100 μM) pretreatment reverses increase in the mRNA and protein level of Bax, caspase 8, cyto c and decrease in the mRNA and protein level of Bcl2 induced by Aβ 25–35 in hOBNSCs[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay[1]
Cell Line:
Human olfactory bulb neural stem cells
Concentration:
100 μM
Incubation Time:
Pre-treatment 4 hours
Result:
Increased hOBNSCs cell viability induced by Aβ 25-35.
分子量
348.52
Formula
C22H36O3
CAS 号
34701-53-6
运输条件
Room temperature in continental US; may vary elsewhere.