Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate(Synonyms: MOG (35-55) (acetate))

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate;(Synonyms: MOG (35-55) (acetate))

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate 引发复发缓解性神经系统疾病,伴有广泛的斑块样脱髓鞘。还能诱导强效的 T细胞和 B 细胞反应,同时是高度脑源性的。

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetateamp;;(Synonyms: MOG (35-55) (acetate))

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate Chemical Structure

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生物活性

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate induces strong T and B cell responses and is highly encephalitogenic[1][2][3].

体内研究
(In Vivo)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG) is a highly autoantigenic molecule capable of inducing severe demyelinating disease[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred female NOD/Lt (H-P’), C57BL/6 (H-2b), C57BL/10 (H-2′), DBAj2 (H-2d), BALB/c (H-2″), BALB/c (H-2b), C3H/HeJ (H-2k), BI0.Br (H-2k), BI0.S (H-2′), SJL/J (H-2′) and PL/J (H-2″) mice[2].
Dosage: 50 μg (100 μg total).
Administration: Injected in each hind footpad.
Result: Mice receiving 50 μg and 100 μg of peptide has more dramatic weight losses during the course of the disease than mice injected with 150 μg.

分子量

2642.00

Formula

C120H181N35O31S

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ichikawa M, et al. Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J Immunol. 1996 Jul 15;157(2):919-26.

    [2]. Slavin A, et al. Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity. 1998;28(2):109-20.

    [3]. Zhang GX, et al. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6 x SJL) F1 mice. J Neuroimmunol. 2004 Mar;148(1-2):1-10.

Relamorelin acetate(Synonyms: RM-131 acetate BIM-28131 acetate)

Relamorelin acetate;(Synonyms: RM-131 acetate; BIM-28131 acetate)

Relamorelin (RM-131) acetate,一种生长素类似物,是一种选择性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂,对 GHS-1a 受体的 Ki 值为 0.42 nM。Relamorelin acetate 是一种五肽,具有中枢渗透性。Relamorelin acetate 增加生长激素水平,加速胃排空,具有用于恶病质、胃轻瘫和胃/肠运动障碍研究的潜力。

Relamorelin acetateamp;;(Synonyms: RM-131 acetate; BIM-28131 acetate)

Relamorelin acetate Chemical Structure

CAS No. : 1809080-14-5

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Relamorelin acetate 的其他形式现货产品:

Relamorelin TFA

生物活性

Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research[1][2][3][4][5].

IC50 Target

Ki: 0.42 nM (GHS-1a)[1]

体外研究
(In Vitro)

Relamorelin (RM-131) acetate shows ∼3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM). Relamorelin acetate is 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) as assessed in vitro by calcium mobilization[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Relamorelin (RM-131; 50-500 nmol/kg/day; s.c.; continuous infusion for 5 days) acetate decreases the loss of body mass and fat mass. Relamorelin (500 nmol/kg/day; continuous infusion for 5 days) acetate increases the food intake and weight gain in rats[1].
RM-131 (250-500 nmol/kg; a single s.c.) acetate stimulates acute food intake in wt but not growth hormone secretagogue receptor (GHR) ko mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: F344/NTacfBR male rats implanted with tumor[1]
Dosage: 50, 500 nmol/kg/day
Administration: SC; continuous infusion at a rate of 0.5 μL/h for 5 d
Result: Resulted in an increase in food intake (tumor/saline 41.4 g, tumor/BIM-28131 72.5 g) and weight gain (tumor/saline -10.3%, tumor/BIM-28131 +19.5%).

Clinical Trial

分子量

851.02

Formula

C45H54N8O7S

CAS 号

1809080-14-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. DeBoer MD, et, al. Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology. 2007 Jun;148(6):3004-12.

    [2]. Fischer K, et, al. The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor. Front Nutr. 2015 Jan 12;1:31.

    [3]. Zatorski H, et, al. Relamorelin and other ghrelin receptor agonists – future options for gastroparesis, functional dyspepsia and proton pump inhibitors-resistant non-erosive reflux disease. J Physiol Pharmacol. 2017 Dec;68(6):797-805.

    [4]. Matthew Heckroth, et al. Nausea and Vomiting in 2021: A Comprehensive Update. J Clin Gastroenterol. 2021 Apr 1;55(4):279-299.

    [5]. Victor Chedid, et al. Relamorelin for the treatment of gastrointestinal motility disorders. Expert Opin Investig Drugs. 2017 Oct;26(10):1189-1197.

F1324 acetate

F1324 acetate;

F1324 acetate 是一种有效、高亲和力的 BCL6 多肽抑制剂,IC50 值为 1 nM。F1324 acetate 结合 BCL6 动力学 t1/2 为 441 s, 对 BCL6 PPI 具有很强的抑制作用。

F1324 acetateamp;;

F1324 acetate Chemical Structure

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生物活性

F1324 acetate is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM. F1324 acetate exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI[1].

IC50 Target

IC50: 1 nM (BCL6)[1]

体外研究
(In Vitro)

F1324 acetate binds to BCL6(5-129) with KD and IC50 values of 0.57 nM and 1 nM according to the results of an SPR analysis and cell-free ELISA assay, respectively[1].
F1324 acetate binds BCL6 not only in cell-free but also cellbased conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1825.09

Formula

C2H4O2

Sequence Shortening

Ac-LWYTDIRMSWRVP-OH

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sakamoto K, et al. Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship. Biochem Biophys Res Commun. 2017 Jan 8;482(2):310-316.

N-Acetyl-Ser-Asp-Lys-Pro acetate(Synonyms: Ac-SDKP acetate)

N-Acetyl-Ser-Asp-Lys-Pro acetate;(Synonyms: Ac-SDKP acetate) 纯度: 98.93%

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate 是血管紧张素转换酶 (ACE) N端活性位点的特异性底物。N-Acetyl-Ser-Asp-Lys-Pro acetate是多能干细胞增殖的天然抑制剂。N-Acetyl-Ser-Asp-Lys-Pro acetate 具有抗炎和抗纤维化特性。

N-Acetyl-Ser-Asp-Lys-Pro acetateamp;;(Synonyms: Ac-SDKP acetate)

N-Acetyl-Ser-Asp-Lys-Pro acetate Chemical Structure

规格 价格 是否有货 数量
1 mg ¥500 In-stock
5 mg ¥1000 In-stock
10 mg ¥1750 In-stock
25 mg ¥3800 In-stock
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N-Acetyl-Ser-Asp-Lys-Pro acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Angiogenesis Related Compound Library
  • Peptide Library

生物活性

N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties[1][2].

分子量

547.56

Formula

C22H37N5O11

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)

溶解性数据
In Vitro:;

DMSO : 100 mg/mL (182.63 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8263 mL 9.1314 mL 18.2628 mL
5 mM 0.3653 mL 1.8263 mL 3.6526 mL
10 mM 0.1826 mL 0.9131 mL 1.8263 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂:;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂:;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂:;10% DMSO ;; 90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.57 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献
  • [1]. Peng H, et al. Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. Hypertension. 2003;42(6):1164-1170.

    [2]. Sharma U, et al. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol. 2008;294(3):H1226-H1232.

Eptifibatide acetate

Eptifibatide acetate;

Eptifibatide acetate 是一种环状七肽,为 glycoprotein IIb/IIIa 受体抑制剂,具有抗血小板活性。

Eptifibatide acetateamp;;

Eptifibatide acetate Chemical Structure

CAS No. : 1248559-53-6

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Eptifibatide acetate 的其他形式现货产品:

Eptifibatide

生物活性

Eptifibatide acetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity[1].

体外研究
(In Vitro)

Eptifibatide is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

892.01

Formula

C37H53N11O11S2

CAS 号

1248559-53-6

Sequence

MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2

Sequence Shortening

MPA-HAR-GDWPC-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gilchrist IC, et al. Platelet glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention: focus on the pharmacokinetic-pharmacodynamic relationships of eptifibatide. Clin Pharmacokinet. 2003;42(8):703-20.

Velmupressin acetate(Synonyms: c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate)

Velmupressin acetate;(Synonyms: c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate)

Velmupressin (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2) acetate 是一种有效选择性的、短效肽的 V2 受体 (V2R) 激动剂,对 hV2R 和 rV2R 的 EC50 值分别为 0.07 和 0.02 nM。

Velmupressin acetateamp;;(Synonyms: c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate)

Velmupressin acetate Chemical Structure

CAS No. : 1647120-04-4

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生物活性

Velmupressin (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2) acetate is a potent, selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.07 and 0.02 nM for hV2R and rV2R, respectively[1].

IC50 Target

EC50: 0.07 nM (hV2R), 0.02 nM (rV2R)[1]

分子量

1006.63

Formula

C44H64ClN11O10S2

CAS 号

1647120-04-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wiśniewski K, et al. Discovery of Potent, Selective, and Short-Acting Peptidic V2 Receptor Agonists. J Med Chem. 2019 May 23;62(10):4991-5005.

MDP1 acetate

MDP1 acetate;

MDP1 acetate 是一种蜂毒肽 (melittin) 衍生肽,可改变革兰氏阳性和革兰氏阴性细菌膜的完整性,并通过膜损伤杀死细菌。MDP1 acetate 对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的耐多药 (MDR) 和参考菌株具有很高的抗菌活性。

MDP1 acetateamp;;

MDP1 acetate Chemical Structure

规格 是否有货
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生物活性

MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa[1].

体外研究
(In Vitro)

MDP1 acetate exhibits more potent antibacterial activities against S. aureus, E. coli and P. aeruginosa.
Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (S. aureus), 1.22 μg/mL (E. coli) and 3.75 μg/mL (P. aeruginosa), respectively[1].
DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL) acetate. Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 acetate on S. aureus and E. coli bacteria by induction of vesicle or pore formation as well as cell lysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2521.05

Formula

C113H206N34O30

Sequence Shortening

GIGAVLKVLTTGLPALIKRKRQQ

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Akbari R, et al. Action mechanism of melittin-derived antimicrobial peptides, MDP1 and MDP2, de novo designed against multidrug resistant bacteria. Amino Acids. 2018;50(9):1231-1243.

Argireline acetate(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate;(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate (Acetyl hexapeptide-3 acetate) 是一种无毒,可渗透皮肤的抗皱肽。Argireline acetate 可显着抑制神经肌肉接头处依赖 Ca2+ 的神经递质释放。Argireline acetate 具有抗皱和抗衰老的作用。

Argireline acetateamp;;(Synonyms: Acetyl hexapeptide-3 acetate)

Argireline acetate Chemical Structure

规格 是否有货
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Argireline acetate 的其他形式现货产品:

Argireline

生物活性

Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity[1][2][3].

体外研究
(In Vitro)

The incubation of Argireline solution in different concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM)) for 48 h have dose dependent antiproliferative effect. Argireline solution incubated in different concentrations with HSF has a dose-dependent antiproliferative effect on those cells. Cellular proliferation is not effected in Argireline low concentration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Argireline is applied to the aged mice twice daily for 6 weeks. There is an improvement in the histological structure of skin tissue in the aged mice; the amount of type I collagen fibers increased, while that of type III collagen fibers decreased. Argireline could improve the histological structure of skin tissue and rejuvenate the aging skin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

949.04

Formula

C36H64N14O14S

Sequence

N-acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2

Sequence Shortening

Ac-EEMQRR-NH2

中文名称

醋酸阿基瑞林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002 Oct;24(5):303-10.

    [2]. Grosicki M, et al. The study of cellular cytotoxicity of argireline – an anti-aging peptide. Acta Biochim Pol. 2014;61(1):29-32.

    [3]. Wang Y, et al. The anti-wrinkle efficacy of Argireline. J Cosmet Laser Ther. 2013 Aug;15(4):237-41.

Felypressin acetate(Synonyms: PLV-2 acetate)

Felypressin acetate;(Synonyms: PLV-2 acetate)

Felypressin acetate (PLV-2 acetate) 是一种非儿茶酚胺的血管收缩剂,也是一种加压素 1 (vasopressin 1) 激动剂。Felypressin acetate 广泛用于牙科手术中。

Felypressin acetateamp;;(Synonyms: PLV-2 acetate)

Felypressin acetate Chemical Structure

CAS No. : 914453-97-7

规格 是否有货
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Felypressin acetate 的其他形式现货产品:

Felypressin

生物活性

Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate is widely used in dental procedures[1][2].

IC50 Target

Vasopressin 1[2]

体外研究
(In Vitro)

Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure[1].
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Formula

C46H65N13O11S2.xC2H4O2

CAS 号

914453-97-7

Sequence

Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CFFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)

中文名称

醋酸苯赖加压素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bronzo AL et al. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31.

    [2]. Cecanho R et al. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.

Indolicidin acetate

Indolicidin acetate; 纯度: 99.54%

Indolicidin acetate 是一种从牛中性粒细胞的细胞质颗粒中纯化的强效抗菌肽。

Indolicidin acetateamp;;

Indolicidin acetate Chemical Structure

规格 价格 是否有货 数量
1 mg ¥2600 In-stock
5 mg ¥7800 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

Indolicidin acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Indolicidin acetate is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils[1].

分子量

1966.34

Formula

C102H136N26O15

Sequence Shortening

ILPWKWPWWPWRR-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

DMSO : 50 mg/mL (25.43 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5086 mL 2.5428 mL 5.0856 mL
5 mM 0.1017 mL 0.5086 mL 1.0171 mL
10 mM 0.0509 mL 0.2543 mL 0.5086 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Falla TJ, et al. Mode of action of the antimicrobial peptide indolicidin. J Biol Chem. 1996;271(32):19298-19303.

    [2]. Selsted ME, et al. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J Biol Chem. 1992;267(7):4292-4295.