Colistin A sulfate hydrate

发表于2024年7月17日由Whatman官网

Colistin A sulfate hydrate;

Colistin A sulfate hydrate 是 Colistin 的一种主要成分。Colistin 是一种多粘菌素抗生素 (antibiotic)。Colistin 可用来对抗由革兰氏阴性菌引起的感染。

Colistin A sulfate hydrate Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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生物活性

Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria^[1].

分子量

1285.55

Formula

C₅₃H₁₀₄N₁₆O₁₈S

Sequence

{Dab}-Thr-{Dab}-{Dab}-{Dab}-{D-Leu}-Leu-{Dab}-{Dab}-Thr (Lactam bridge:Dab-4-Thr-10)

Sequence Shortening

{Dab}T{Dab}{Dab}{Dab}{D-Leu}L{Dab}{Dab}T (Lactam bridge:Dab-4-Thr-10)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Lauren M. Lim, et al. Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing. Pharmacotherapy. 2010 Dec; 30(12): 1279-1291.

日本同仁化学Hampton蛋白结晶试剂盒Cadmium chloride hydrate/HR2-715| DOJINDO

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Products > Optimize Reagents > Optimize – Salts > Cadmium chloride hydrate

Cadmium chloride hydrate

CAT NO

HR2-715

NAME

1.0 M Cadmium chloride hydrate

DESCRIPTION

100 mL

PRICE

$132.00

支持材料

HR2-715 Cadmium chloride hydrate SDS

应用

Crystallization grade Cadmium chloride hydrate for formulating screens or for optimization
结晶级氯化镉水合物，用于配制屏幕或优化

特征

Sterile filtered solution
Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL)
无菌过滤溶液
在 1+ 型超纯水中配制：25°C 时电阻率为 18.2 兆欧厘米，总有机碳 < 5 ppb，无细菌（<1 细菌 (CFU/ml)），无热原（<0.03 内毒素 (EU/ml)） , 无 RNase (< 0.01 ng/mL) 和无 DNase (< 4 pg/µL)

描述Cadmium chloride hydrate

Synonyms: None
CdCl₂• xH₂O
M_r 183.32
CAS [654054-66-7]
EC Number 233-296-7
Merck 14,1617
UN Number 2570 6.1/PG 3
MDL Number MFCD00149627
PubChem Substance ID 24852504
Purity > 98.0%

Measured pH range: 2.8 – 5.0 at 25°C
Measured Conductivity Range: 26.7 – 28.9 mS/cm at 25°C
Measured Refractive Index Range: 1.35410 – 1.35683 at 20°C

同义词：无
CdCl2 • xH2O
183.32 先生
CAS [654054-66-7]
欧盟编号 233-296-7
默克 14,1617
联合国编号 2570 6.1/PG 3
MDL 编号 MFCD00149627
PubChem 物质 ID 24852504
纯度 > 98.0%

测得的 pH 值范围：25°C 时 2.8 – 5.0
测量的电导率范围：26.7 – 28.9 mS/cm 在 25°C
测得的折射率范围：20°C 时为 1.35410 – 1.35683

参考Cadmium chloride hydrate

1. Crystallization and preliminary crystallographic data for the Azurin mutant End-121 from Pseudomonas aeruginosa. Strange, RW; Murphy, L; Karlsson, G; Lindley, P; Lundberg, LG; Reinhammar, B; Hasnan, SS. Acta Crystallogr D 50, 37- 39, 1994.

2. Characterization and preliminary attempts for Derivatization of Crystals of Large ribosomal subunits from Haloarcula marismortui diffracting to 3 A resolution. von Bohlen, K; Makowski, I; Hansen, HAS; Bartels, H; Berkovitch-Yellin, Z; Zaytzev-Bashan, A; Meyer, S; Paulke, C; Franceschi, F; Yonath, A. J Mol Biol 222, 11- 15, 1991.

1. 来自铜绿假单胞菌的 Azurin 突变体 End-121 的结晶和初步结晶学数据。奇怪，RW；墨菲，L；卡尔森，G；林德利，P；伦德伯格，LG；莱因哈马尔，B；哈斯南，SS。晶体学学报 D 50, 37-39, 1994。

2. 来自 Haloarcula marismortui 的大核糖体亚基晶体衍生化的表征和初步尝试，衍射到 3 A 分辨率。冯·博伦，K；马科夫斯基，我；汉森，有；巴特尔斯，H；伯科维奇-耶林，Z；扎伊采夫-巴山，A；迈耶，S；保尔克，C；弗朗切斯基，F； Yonath, A. J Mol Biol 222, 11-15, 1991。

日本同仁化学Hampton蛋白结晶试剂盒Cadmium sulfate hydrate/HR2-721| DOJINDO

发表于2024年6月18日由Whatman官网

上海金畔生物科技有限公司代理日本同仁化学 DOJINDO代理商全线产品，欢迎访问官网了解更多信息

Products > Optimize Reagents > Optimize – Salts > Cadmium sulfate hydrate

Cadmium sulfate hydrate

CAT NO

HR2-721

NAME

1.0 M Cadmium sulfate hydrate

DESCRIPTION

100 mL

PRICE

$120.00

支持材料

HR2-721 Cadmium sulfate hydrate SDS

应用

Crystallization grade Cadmium sulfate hydrate for formulating screens or for optimization
结晶级硫酸镉水合物，用于配制屏幕或优化

特征

Sterile filtered solution
Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL)
无菌过滤溶液
在 1+ 型超纯水中配制：25°C 时电阻率为 18.2 兆欧厘米，总有机碳 < 5 ppb，无细菌（<1 细菌 (CFU/ml)），无热原（<0.03 内毒素 (EU/ml)） , 无 RNase (< 0.01 ng/mL) 和无 DNase (< 4 pg/µL)

描述Cadmium sulfate hydrate

Synonyms: Cadmium sulfate octahydrate
3CdSO₄ • 8H₂O
3CdO₄S • 8H₂O
M_r 769.52
CAS Number [15244-35-6]
EC Number 233-331-6
Merck 14,1627
RTECS EV2850000
MDL Number MFCD00151655
Purity 98.0% (calc. based on CdSO4 • 8/3 H2O, KT)

Measured pH Range: 1.5 – 2.1 at 25°C
Measured Conductivity Range: 43.6 – 46.5 mS/cm at 25°C
Measured Refractive Index Range: 1.40247 – 1.40679 at 20°C

别名：八水硫酸镉
3CdSO4 • 8H2O
3CdO4S • 8H2O
769.52 先生
CAS 编号 [15244-35-6]
欧盟编号 233-331-6
默克 14,1627
RTECS EV2850000
MDL 编号 MFCD00151655
纯度 98.0%（基于 CdSO4 • 8/3 H2O，KT 计算）

测得的 pH 值范围：25°C 时为 1.5 – 2.1
测得的电导率范围：25°C 时为 43.6 – 46.5 mS/cm
测得的折射率范围：20°C 时为 1.40247 – 1.40679

As ≤0.0002%
Ca ≤0.005%
Cl ≤0.001%
Co ≤0.0005%
Cr ≤0.0005%
Cu ≤0.0005%
Fe ≤0.0005%
K ≤0.005%
Mg ≤0.0005%
Mn ≤0.0005%
N ≤0.003%
Na ≤0.005%
Ni ≤0.0005%
Pb ≤0.002%
Zn ≤0.005%

参考Cadmium sulfate hydrate

1. Selective crystallization of horse isoferritins. Arosio P, Gatti G, Bolognesi M. Biochim Biophys Acta. 1983 Apr 28;744(2):230-2.

2. Ferritin: Its Properties and Significance for Iron Metabolism. S. Granick. Chem. Rev.; 1946; 38(3) pp 379 – 403.

1.马异铁蛋白的选择性结晶。 Arosio P, Gatti G, Bolognesi M. Biochim Biophys Acta。 1983 年 4 月 28 日；744(2):230-2。

2. 铁蛋白：铁代谢的性质和意义。 S.格兰尼克。化学。牧师； 1946; 38(3) 第 379 – 403 页。

日本同仁化学Hampton蛋白结晶试剂盒Calcium acetate hydrate/HR2-567| DOJINDO

发表于2024年6月18日由Whatman官网

上海金畔生物科技有限公司代理日本同仁化学 DOJINDO代理商全线产品，欢迎访问官网了解更多信息

Products > Optimize Reagents > Optimize – Salts > Calcium acetate hydrate

Calcium acetate hydrate

CAT NO

HR2-567

NAME

1.0 M Calcium acetate hydrate

DESCRIPTION

100 mL

PRICE

$93.00

支持材料

HR2-567 Calcium acetate hydrate SDS

应用

Crystallization grade Calcium acetate for formulating screens or for optimization
结晶级醋酸钙，用于配制筛选或优化

特征

Sterile filtered solution
Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL)
无菌过滤溶液
在 1+ 型超纯水中配制：25°C 时电阻率为 18.2 兆欧厘米，总有机碳 < 5 ppb，无细菌（<1 细菌 (CFU/ml)），无热原（<0.03 内毒素 (EU/ml)） , 无 RNase (< 0.01 ng/mL) 和无 DNase (< 4 pg/µL)

描述Calcium acetate hydrate

Synonyms: Calcium diacetate
(CH₃COO)₂Ca • xH₂O
C₄H₆CaO₄• xH₂O
M_r 158.17 + aq
CAS Number [114460-21-8]
EC Number 200-540-9
Beilstein Registry Number 3692527
Merck 14,1646
RTECS AF7525000
MDL Number MFCD00150019
PubChem Substance ID 24852644
Purity ≥ 99.0%

Measured pH Range: 7.6 – 7.9 at 25°C
Measured Conductivity range: 34.1 – 38.1 mS/cm at 25°C
Measured Refractive Index range: 1.35697 – 1.35776 at 20°C

别名：二醋酸钙
(CH3COO)2Ca • xH2O
C4H6CaO4 • xH2O
先生 158.17 + aq
CAS 编号 [114460-21-8]
欧盟编号 200-540-9
贝尔斯坦注册号 3692527
默克 14,1646
RTECS AF7525000
MDL 编号 MFCD00150019
PubChem 物质 ID 24852644
纯度≥99.0%

测得的 pH 值范围：25°C 时为 7.6 – 7.9
测得的电导率范围：25°C 时 34.1 – 38.1 mS/cm
测得的折射率范围：20°C 时为 1.35697 – 1.35776

As ≤0.00001%
Ba ≤0.0002%
Bi ≤0.0005%
Cd ≤0.0005%
Cl ≤0.005%
Co ≤0.0005%
Cr ≤0.0005%
Cu ≤0.0005%
Fe ≤0.0005%
K ≤0.01%
Li ≤0.0005%
Mg ≤0.1%
Mn ≤0.0005%
Mo ≤0.0005%
Na ≤0.015%
Ni ≤0.0005%
Pb ≤0.0005%
SO₄ ≤0.02%
Sr ≤0.02%
Zn ≤0.0005%

参考Calcium acetate hydrate

1. Structure of the B-DNA Decamer C-C-A-A-C-I-T-T-G-G in Two Different Space Groups: Conformational Flexibility of B-DNA. Lipanov, A; Kopka, ML; Kaczor-Grzeskowiak, M; Quintana, J; Dickerson, RE. Biochemistry 32, 1373- 1389, 1993.

1. B-DNA 十聚体 C-C-A-A-C-I-T-T-G-G 在两个不同空间群中的结构：B-DNA 的构象灵活性。利帕诺夫，A；科普卡，毫升；卡佐尔-格热斯科维亚克，M；金塔纳，J；迪克森，RE。生物化学 32, 1373-1389, 1993。

日本同仁化学Hampton蛋白结晶试剂盒Magnesium sulfate hydrate/HR2-633| DOJINDO

发表于2024年6月17日由Whatman官网

上海金畔生物科技有限公司代理日本同仁化学 DOJINDO代理商全线产品，欢迎访问官网了解更多信息

Products > Optimize Reagents > Optimize – Salts > Magnesium sulfate hydrate

Magnesium sulfate hydrate

CAT NO

HR2-633

NAME

2.5 M Magnesium sulfate hydrate

DESCRIPTION

200 mL

PRICE

$113.00

支持材料

HR2-633 Magnesium sulfate hydrate SDS

应用

Crystallization grade Magnesium sulfate hydrate for formulating screens or for optimization
结晶级硫酸镁水合物，用于配制屏幕或优化

特征

Sterile filtered solution
Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL)
无菌过滤溶液
在 1+ 型超纯水中配制：25°C 时电阻率为 18.2 兆欧厘米，总有机碳 < 5 ppb，无细菌（<1 细菌 (CFU/ml)），无热原（<0.03 内毒素 (EU/ml)） , 无 RNase (< 0.01 ng/mL) 和无 DNase (< 4 pg/µL)

描述Magnesium sulfate hydrate

Synonyms: Magnesium sulphate hydrate
MgSO₄ • aqueous
M_r 120.37 • aqueous
CAS Number [22189-08-8]
EC Number 231-298-2
MDL Number MFCD00011110
PubChem Substance ID 24882418
Purity ≥ 99.0%

Measured pH Range: 7.8 – 8.3 at 25°C
Measured Conductivity Range: 57.9 – 59.1 mS/cm at 25°C
Measured Refractive Index Range: 1.36702 – 1.37174 at 20°C

别名：硫酸镁水合物
MgSO4 • 水溶液
Mr 120.37 • 水溶液
CAS 编号 [22189-08-8]
欧盟编号 231-298-2
MDL 编号 MFCD00011110
PubChem 物质 ID 24882418
纯度≥99.0%

测得的 pH 值范围：25°C 时为 7.8 – 8.3
测得的电导率范围：25°C 时 57.9 – 59.1 mS/cm
测得的折射率范围：20°C 时为 1.36702 – 1.37174

Ca ≤0.02%
Cd ≤0.005%
Cl ≤0.01%
Co ≤0.005%
Cu ≤0.005%
Fe ≤0.005%
K ≤0.05%
Na ≤0.01%
Ni ≤0.005%
Pb ≤0.005%
Zn ≤0.005%

Magnesium sulfate hydrate

参考

1. Rudikoff, S; Potter, M; Segal, DM; Padlan, EA; Davies, DR; Proc Natl Acad Sci U S A 69, 3689- 3692, 1972.

1.鲁迪科夫，S；波特，M；西格尔，DM；帕德兰，EA；戴维斯博士； Proc Natl Acad Sci U S A 69, 3689-3692, 1972。

(+)-Catechin hydrate(Synonyms: (+)-水合儿茶素)

发表于2024年5月3日由Whatman官网

天然产物黄酮类 Flavonoids

(+)-Catechin hydrate (Synonyms: (+)-水合儿茶素) 纯度: 99.59%

(+)-Catechin hydrate 抑制环加氧酶-1 (COX-1) , IC₅₀ 为 1.4 μM。

(+)-Catechin hydrate Chemical Structure

CAS No. : 225937-10-0

规格	价格	是否有货
100 mg	￥500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

(+)-Catechin hydrate 相关产品

•相关化合物库:

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Drug Repurposing Compound Library
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Anti-COVID-19 Compound Library
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Flavonoids Library
Food-Sourced Compound Library

生物活性

(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

IC₅₀ & Target^[1]

COX-1

1.4 μM (IC₅₀)

体外研究
(In Vitro)

(+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM^[1]. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC₅₀ of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Formula

C₁₅H₁₄O₆.xH₂O

CAS 号

225937-10-0

中文名称

(+)-水合儿茶素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL (Need ultrasonic)

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (Infinity mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (Infinity mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.

[2]. Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167.

[3]. Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259.

Cell Assay ^[2]	The Cell viability assay is performed to assess the toxicity of different concentrations of (+)-Catechin on MCF-7 cells. Briefly, MCF-7 cells (2×10⁴ cells/well) are plated in 96-well plates and treated with 0 μg/mL (+)-Catechin and 160 μg/mL (+)-Catechin for 24 hours. Then, 40 μL of the Cell Titer Blue solution is directly added to the wells and incubated at 37°C for 6 hours. The fluorescence is recorded with a 560 nm/590 nm (excitation/emission) filter set using a microplate fluorescence reader, and the IC₅₀ is calculated. Quadruplet samples are run for each concentration of (+)-Catechin in three independent experiments^[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[3]	Rats^[3] Twelve weeks old, healthy male rats weighing 200 to 230 g are used in this study. Rats are divided into four experimental groups (n=9 each) for one vehicle and three groups of (+)-Catechin (three doses). The doses of (+)-Catechin are prepared at 50, 100, 200 mg/kg and administered orally for 7 days prior to and during the experimental trials. Episodic memory, the conscious memory of the past experiences is evaluated in this study^[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [2]. Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167. [3]. Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259.

Rutin hydrate(Synonyms: Rutoside hydrate; Quercetin 3-O-rutinoside hydrate)

发表于2024年4月29日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Rutin hydrate;(Synonyms: Rutoside hydrate; Quercetin 3-O-rutinoside hydrate) 纯度: ge;98.0%

Rutin (Rutoside) hydrate 是一种广泛存在于多种植物中的黄酮类化合物，具有抗炎、降糖、抗氧化、神经保护、肾脏保护、肝脏保护和降低 Aβ 低聚物活性等多种生物活性。Rutin hydrate 能穿过血脑屏障。Rutin hydrate 通过抑制细胞凋亡、线粒体功能紊乱和氧化应激抑制万古霉素诱导的肾小管细胞凋亡。

Rutin hydrate Chemical Structure

CAS No. : 207671-50-9

规格	价格	是否有货	数量
Free Sample (0.1-0.5 mg)	;	Apply now	;
500 mg	￥400	In-stock
1 g	;	询价	;
5 g	;	询价	;

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Rutin hydrate 相关产品

bull;相关化合物库:

Natural Product Library Plus
Drug Repurposing Compound Library Plus
FDA-Approved Drug Library Plus
Bioactive Compound Library Plus

生物活性

Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress^[1]^[2]^[3].

体内研究
(In Vivo)

Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signaling^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

740.26

Formula

C₂₇H₃₂O₁₇

CAS 号

207671-50-9

中文名称

芸香苷水合物；紫皮甙水合物；维生素 P 水合物；芦丁水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)

溶解性数据

In Vitro:;

DMSO : 50 mg/mL (67.54 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3509 mL	6.7544 mL	13.5088 mL
5 mM	0.2702 mL	1.3509 mL	2.7018 mL
10 mM	0.1351 mL	0.6754 mL	1.3509 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.38 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.38 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.38 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312.

[2]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer’s Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.

[3]. Xu PX, et al. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180.

[4]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377.

Animal Administration ^[1]	Rats^[1] (1) A control group receives of 0.01 g/mL carboxymethylcellulose (CMC) dissolved in distilled water; (2) α-tocopherol acetate treated group: control rats receive α-tocopherol (120 IU/rat) diluted in 0.1 mL of coconut oil; (3) Rutin hydrate treated control group (control + Rutin hydrate): control rats receive Rutin hydrate (100 mg/kg); (4) CdCl₂ intoxicated group receives CdCl₂ at a final dose of 5 mg/kg to induce neurotoxicity; (5) CdCl₂ + Rutin hydrate treated group (CdCl₂ + Rutin hydrate) receives CdCl₂ (5 mg/kg) and receives a coincided dose of Rutin hydrate (100 mg/kg body weight); (6) CdCl₂ + Rutin hydrate + α-tocopherol acetate-treated group receives CdCl₂ (5 mg/kg) and receives concomitant dose of Rutin hydrate (100 mg/kg) in conjugation with α-tocopherol acetate (120 IU/rat) that is diluted in 0.1 mL of coconut oil. All treatments are given by orogastric gavage with a polyethylene catheter PE 190 daily for 30 days^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312. [2]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer’s Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873. [3]. Xu PX, et al. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180. [4]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377.

Animal Administration
^[1]

Rats^[1]
(1) A control group receives of 0.01 g/mL carboxymethylcellulose (CMC) dissolved in distilled water; (2) α-tocopherol acetate treated group: control rats receive α-tocopherol (120 IU/rat) diluted in 0.1 mL of coconut oil; (3) Rutin hydrate treated control group (control + Rutin hydrate): control rats receive Rutin hydrate (100 mg/kg); (4) CdCl₂ intoxicated group receives CdCl₂ at a final dose of 5 mg/kg to induce neurotoxicity; (5) CdCl₂ + Rutin hydrate treated group (CdCl₂ + Rutin hydrate) receives CdCl₂ (5 mg/kg) and receives a coincided dose of Rutin hydrate (100 mg/kg body weight); (6) CdCl₂ + Rutin hydrate + α-tocopherol acetate-treated group receives CdCl₂ (5 mg/kg) and receives concomitant dose of Rutin hydrate (100 mg/kg) in conjugation with α-tocopherol acetate (120 IU/rat) that is diluted in 0.1 mL of coconut oil. All treatments are given by orogastric gavage with a polyethylene catheter PE 190 daily for 30 days^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Ghorbani A. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother. 2017;96:305-312.

[2]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer’s Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.

[3]. Xu PX, et al. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res. 2014;264:173-180.

[4]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018;124(4):367-377.

Oxypeucedanin hydrate(Synonyms: (+)-Oxypeucedanin hydrate)

发表于2024年4月17日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

Oxypeucedanin hydrate (Synonyms: (+)-Oxypeucedanin hydrate)

Oxypeucedanin hydrate ((+)-Oxypeucedanin hydrate) 是从 D. anethifolia 中分离出的一种天然产物。 Prangol 对成纤维细胞和母淋巴瘤细胞有轻微毒性。

Oxypeucedanin hydrate Chemical Structure

CAS No. : 2643-85-8

规格	价格	是否有货
5 mg	￥1300	In-stock
10 mg	￥2000	In-stock
25 mg	￥4100	In-stock
50 mg	￥6500	In-stock
100 mg		询价
200 mg		询价

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Oxypeucedanin hydrate 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Natural Product Library
Anti-Cancer Compound Library
Anti-Blood Cancer Compound Library

生物活性

Oxypeucedanin hydrate ((+)-Oxypeucedanin hydrate) is a natural product isolated from D. anethifolia. Prangol exhibits mild toxicity on fibroblasts and parental lymphoma cells^[1].

分子量

304.29

Formula

C₁₆H₁₆O₆

CAS 号

2643-85-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Mottaghipisheh J, et al. Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia. Pharm Biol. 2018 Dec;56(1):658-664.

(-)-Oxypeucedanin hydrate(Synonyms: (-)-Prangol)

发表于2024年4月11日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

(-)-Oxypeucedanin hydrate (Synonyms: (-)-Prangol)

(-)-Oxypeucedanin hydrate ((-)-Prangol) 是从 Ducrosia anethifolia 中分离得到的呋喃香豆素衍生物。

(-)-Oxypeucedanin hydrate Chemical Structure

CAS No. : 133164-11-1

规格		是否有货
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10 mg		询价
25 mg		询价

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生物活性	(-)-Oxypeucedanin hydrate ((-)-Prangol) is a derivative of furocoumarin isolated from Ducrosia anethifolia^[1].
体外研究 (In Vitro)	D. anethifolia furocoumarin shows antiproliferative and cytotoxic activities^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	304.29
Formula	C₁₆H₁₆O₆
CAS 号	133164-11-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Mottaghipisheh J, et al. Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia. Pharm Biol. 2018;56(1):658-664.

Osthol hydrate(Synonyms: 水合蛇床子素)

发表于2024年4月11日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

Osthol hydrate (Synonyms: 水合蛇床子素)

Osthol hydrate 是从 F. schottiana 中分离出的一种天然产物。

Osthol hydrate Chemical Structure

CAS No. : 69219-24-5

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10 mg		询价
25 mg		询价

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生物活性	Osthol hydrate is a natural product isolated from F. schottiana^[1].
分子量	262.30
Formula	C₁₅H₁₈O₄
CAS 号	69219-24-5
中文名称	水合蛇床子素
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Hollis, A., et al. The Chemical Constituents of Australian Flindersia Species. XIV. The Constituents of Flindersia pubescens Bail. And F. schottiana F. Muell. Australian Journal of Chemistry, 1961;14(1), 100.

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