Colistin A sulfate hydrate;
Colistin A sulfate hydrate 是 Colistin 的一种主要成分。Colistin 是一种多粘菌素抗生素 (antibiotic)。Colistin 可用来对抗由革兰氏阴性菌引起的感染。
Colistin A sulfate hydrate Chemical Structure
规格 |
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是否有货 |
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100 mg |
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询价 |
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250 mg |
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询价 |
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500 mg |
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询价 |
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* Please select Quantity before adding items.
生物活性 |
Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria[1].
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分子量 |
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Formula |
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Sequence |
{Dab}-Thr-{Dab}-{Dab}-{Dab}-{D-Leu}-Leu-{Dab}-{Dab}-Thr (Lactam bridge:Dab-4-Thr-10)
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Sequence Shortening |
{Dab}T{Dab}{Dab}{Dab}{D-Leu}L{Dab}{Dab}T (Lactam bridge:Dab-4-Thr-10)
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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Solvent Solubility |
In Vitro:;
H2O
Peptide Solubility and Storage Guidelines:
1.;;Calculate the length of the peptide.
2.;;Calculate the overall charge of the entire peptide according to the following table:
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Contents |
Assign value |
Acidic amino acid |
Asp (D), Glu (E), and the C-terminal -COOH. |
-1 |
Basic amino acid |
Arg (R), Lys (K), His (H), and the N-terminal -NH2 |
+1 |
Neutral amino acid |
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) |
0 |
3.;;Recommended solution:
Overall charge of peptide |
Details |
Negative (lt;0) |
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH4OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
Positive (gt;0) |
1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
Zero (=0) |
1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
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参考文献 |
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[1]. Lauren M. Lim, et al. Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing. Pharmacotherapy. 2010 Dec; 30(12): 1279-1291.
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