生化分析试剂 Biochemical Assay Reagents
Methylproamine; 纯度: 99.84%
Methylproamine是DNA结合的辐射保护剂,能修复辐射诱导的短暂活性氧。
Methylproamine Chemical Structure
CAS No. : 188247-01-0
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | ; | Apply now | ; |
10;mM;*;1 mL in DMSO | ¥2640 | In-stock | |
50 mg | ¥2400 | In-stock | |
100 mg | ¥3200 | In-stock | |
200 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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Methylproamine 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
生物活性 |
Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA. IC50 Value: N/A Target: DNA-binding radioprotector in vitro: The extent of radioprotection at the clonogenic survival endpoint increased with methylproamine concentration up to a maximum dose modification factor (DMF) of 2.0 at 10 μM. At least 0.1 fmole/nucleus of methylproamine is required to achieve a substantial level of radioprotection (DMF of 1.3) with maximum protection (DMF of 2.0) achieved at 0.23 fmole/nucleus. The γH2AX focus yield per cell nucleus 45 min after irradiation decreased with drug concentration with a DMF of 2.5 at 10 μM [1]. Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence ofmethylproamine decreased the amount of lower molecular weight DNA entering the gel as shown by the pulsed field gel electrophoresis assay [2]. Experiments with V79 cells have shown that methylproamine is approximately 100-fold more potent than the classical aminothiol radioprotector WR1065. The crystal structures of methylproamine and proamine complexes with the dodecamer d(CGCGAATTCGCG)(2) confirm that the new analogues also are minor groove binders [3]. in vivo: N/A Clinical trial: N/A |
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分子量 |
465.59 |
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Formula |
C28H31N7 |
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CAS 号 |
188247-01-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 41 mg/mL (88.06 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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